2004
DOI: 10.1111/j.1399-5618.2004.00120.x
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Bipolar‐panic disorder comorbidity within bipolar disorder families: a study of siblings

Abstract: The absence of panic disorder and the low prevalence of any panic symptoms in those without bipolar or unipolar disorder suggest that panic is associated primarily with affective disorder within families with a history of bipolar disorder. Furthermore, panic disorder and symptoms are more common in bipolar disorder than in unipolar disorder in these families.

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Cited by 49 publications
(40 citation statements)
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“…We found a higher but not significant proportion of comorbid anxiety disorders are associated with bipolar II and bipolar NOS disorders rather than bipolar I disorder, in accordance to previous studies [Cassano et al, 1999;Doughty et al, 2004;Pini et al, 1997;Perugi et al, 1999]. Specific types of comorbid anxiety disorders that had been demonstrated to be strongly associated with bipolar disorder include PD [Cassano et al, 1999;Chen and Dilsaver, 1995a;Doughty et al, 2004;Mantere et al, 2006;Rihmer et al, 2001], PTSD [Mantere et al, 2006;Otto et al, 2004], OCD [Angst, 1998;Chen and Dilsaver, 1995b;Perugi et al, 1997Perugi et al, , 1999, and simple phobia [Mantere et al, 2006;Rihmer et al, 2001]. However, it is noteworthy that the rates of anxiety disorder comorbidity differ in these studies.…”
Section: Discussionsupporting
confidence: 94%
“…We found a higher but not significant proportion of comorbid anxiety disorders are associated with bipolar II and bipolar NOS disorders rather than bipolar I disorder, in accordance to previous studies [Cassano et al, 1999;Doughty et al, 2004;Pini et al, 1997;Perugi et al, 1999]. Specific types of comorbid anxiety disorders that had been demonstrated to be strongly associated with bipolar disorder include PD [Cassano et al, 1999;Chen and Dilsaver, 1995a;Doughty et al, 2004;Mantere et al, 2006;Rihmer et al, 2001], PTSD [Mantere et al, 2006;Otto et al, 2004], OCD [Angst, 1998;Chen and Dilsaver, 1995b;Perugi et al, 1997Perugi et al, , 1999, and simple phobia [Mantere et al, 2006;Rihmer et al, 2001]. However, it is noteworthy that the rates of anxiety disorder comorbidity differ in these studies.…”
Section: Discussionsupporting
confidence: 94%
“…[59][60] In 2002 MacKinnon et al 61 studied 203 families of probands with BD and demonstrated that family history of BD is a risk factor of PD. This hypothesis was also reinforced by Doughty et al 62 who assessed 109 families of bipolar probands and confirmed data that PD is primarily associated with affective disorder in families with BD history. This clinical finding is corroborated by neurochemical studies, which found the association of PD comorbidity with markers in the long arm of the chromosome 18 of BD patients.…”
Section: Introduction Introduction Introduction Introduction Introducsupporting
confidence: 56%
“…Concerning anxiety symptoms in unipolar and bipolar mood disorders, it should be mentioned that in the EPIDEP study, psychic anxiety symptoms were more frequent in unipolar than in bipolar II disorder [12] . On the other hand, a recent sibling study found a higher frequency of panic attacks in bipolar than in unipolar patients [26] .…”
Section: Discussionmentioning
confidence: 98%