Bipolar‐panic disorder comorbidity within bipolar disorder families: a study of siblings

Doughty, Carolyn; Wells, J. Elisabeth; Joyce, Peter R.; Olds, R.J.; Walsh, Annabel

doi:10.1111/j.1399-5618.2004.00120.x

Cited by 49 publications

(40 citation statements)

References 42 publications

(47 reference statements)

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“…We found a higher but not significant proportion of comorbid anxiety disorders are associated with bipolar II and bipolar NOS disorders rather than bipolar I disorder, in accordance to previous studies [Cassano et al, 1999;Doughty et al, 2004;Pini et al, 1997;Perugi et al, 1999]. Specific types of comorbid anxiety disorders that had been demonstrated to be strongly associated with bipolar disorder include PD [Cassano et al, 1999;Chen and Dilsaver, 1995a;Doughty et al, 2004;Mantere et al, 2006;Rihmer et al, 2001], PTSD [Mantere et al, 2006;Otto et al, 2004], OCD [Angst, 1998;Chen and Dilsaver, 1995b;Perugi et al, 1997Perugi et al, , 1999, and simple phobia [Mantere et al, 2006;Rihmer et al, 2001]. However, it is noteworthy that the rates of anxiety disorder comorbidity differ in these studies.…”

Section: Discussionsupporting

confidence: 94%

The effect of anxiety disorder comorbidity on treatment resistant bipolar disorders

Lee

Dünner

2008

Depress. Anxiety

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High rates of anxiety disorders have been reported in bipolar disorders. We undertook this study to determine the impact of anxiety disorders on bipolar disorders in our tertiary care referral center. We reviewed the literature on this topic and also reviewed records of 44 treatment resistant bipolar patients evaluated by DLD at the Center for Anxiety and Depression. Twenty-three patients had comorbid panic disorder, posttraumatic stress disorder, or obsessive-compulsive disorder. We compared bipolar patients with and without a history of comorbid anxiety disorders regarding several clinical factors, including mean age, percentage of women, mean age of onset, history of suicide attempts, history of rapid cycling, history of substance abuse, family history, and mean ratings for mood rating scales. Statistical differences were assessed by chi(2) and t-tests. On several measures, bipolar patients with comorbid anxiety disorders were more significantly ill than bipolar patients without comorbid anxiety disorders. For instance, patients with an anxiety disorder were more likely to have an earlier age of onset of illness, have higher (worse) ratings on the Hamilton Anxiety Rating Scale, 17-item Hamilton Depression Rating Scale, Montgomery and Asberg Depression Rating Scale, Beck Depression Inventory, and lower (more impaired) ratings on the Global Assessment of Functioning Scale. Comorbid anxiety disorders were also associated with a more frequent history of substance abuse and higher ratings for suicidal ideation. Anxiety disorders negatively impact the course of bipolar disorders. The high prevalence and risk rate of comorbid anxiety disorders in bipolar patients highlight the need for greater clinical attention to this population.

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Section: Discussionsupporting

confidence: 94%

The effect of anxiety disorder comorbidity on treatment resistant bipolar disorders

Lee

Dünner

2008

Depress. Anxiety

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“…[59][60] In 2002 MacKinnon et al 61 studied 203 families of probands with BD and demonstrated that family history of BD is a risk factor of PD. This hypothesis was also reinforced by Doughty et al 62 who assessed 109 families of bipolar probands and confirmed data that PD is primarily associated with affective disorder in families with BD history. This clinical finding is corroborated by neurochemical studies, which found the association of PD comorbidity with markers in the long arm of the chromosome 18 of BD patients.…”

Section: Introduction Introduction Introduction Introduction Introducsupporting

confidence: 56%

Comorbidade com transtornos de ansiedade em transtorno bipolar

Issler

Sant’Anna

Kapczinski

et al. 2004

Rev. Bras. Psiquiatr.

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“…Concerning anxiety symptoms in unipolar and bipolar mood disorders, it should be mentioned that in the EPIDEP study, psychic anxiety symptoms were more frequent in unipolar than in bipolar II disorder [12] . On the other hand, a recent sibling study found a higher frequency of panic attacks in bipolar than in unipolar patients [26] .…”

Section: Discussionmentioning

confidence: 98%

Types of Depression More Frequent in Bipolar than in Unipolar Affective Illness: Results of the Polish DEP-BI Study

et al. 2007

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Background: The aim of the study was to assess the relative frequency of various kinds of depression in patients with bipolar and unipolar affective illness. The study was performed in the framework of the DEP-BI project aimed at assessing the prevalence of bipolar disorders among depressive outpatients treated by psychiatrists in Poland. Methods: Eight-hundred and eighty patients (237 male, 643 female) participated in the study. The patients were classified into the following diagnostic categories: bipolar affective illness type I, type II, bipolar spectrum disorder and unipolar affective illness. The various kinds of depression in each group were assessed by means of a semistructured questionnaire added to the diagnostic interview. Results: In the group of bipolar patients, a significantly higher frequency of psychotic depression in male compared to female patients was observed. Male bipolar patients compared with unipolar depressed ones had significantly more episodes of psychotic depression (odds ratio, OR, 4.29) and atypical depression (hypersomnia and hyperphagia; OR 2.82), and those with bipolar spectrum had more episodes of treatment-resistant depression (OR 2.56). Female bipolar patients compared with unipolar depressed ones had significantly more frequently an early onset of depression (before 25 years; OR 2.95) and postpartum depression (OR 2.48). On the other hand, the percentage of agitation, irritability, distractibility, thought racing and panic attacks during depression was not different in patients with bipolar and unipolar affective illness either in males or females. Conclusions: Some kinds of depression occur with a higher frequency in patients with bipolar compared to unipolar affective illness. The occurrence of a given type of depression may constitute an aid for the diagnosis of bipolar illness. The results of this study did not confirm the concept of bipolar mixed depression based on the presence of anxiety symptoms occurring during the depressive episode. The limitation of our study may be the lack of formal criteria or a structured interview to assess the symptoms occurring during depressive episodes.

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Bipolar‐panic disorder comorbidity within bipolar disorder families: a study of siblings

Cited by 49 publications

References 42 publications

The effect of anxiety disorder comorbidity on treatment resistant bipolar disorders

The effect of anxiety disorder comorbidity on treatment resistant bipolar disorders

Comorbidade com transtornos de ansiedade em transtorno bipolar

Types of Depression More Frequent in Bipolar than in Unipolar Affective Illness: Results of the Polish DEP-BI Study

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