Bipolar I patients with and without a history of psychotic symptoms: Do they differ in their cognitive functioning?

Selva, Gabriel; Salazar, José; Balanzá‐Martínez, Vicent; Martínez‐Arán, Anabel; Rubio, Claudia Grau; Daban, Claire; Sánchez-Moreno, José; Vieta, Eduard; Tabarés‐Seisdedos, Rafael

doi:10.1016/j.jpsychires.2006.03.007

Cited by 96 publications

(84 citation statements)

References 40 publications

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“…Another possible explanation is that the sample size is not large enough to show this difference, considering that the sample was calculated seeking a difference between euthymic patients and healthy subjects. However, our results agree with most studies 19,21,34,35 that indicate real neuropsychological damage. As to the verbal area of cognition, both the depressed patients and euthymic group had statistically lower scores than controls in three out of the six subtests applied.…”

Section: Discussionsupporting

confidence: 92%

“…19 Martinez-Arán et al 20 found that the duration of illness, number of manic episodes, hospitalizations and attempted suicide were associated with poorer cognitive performance. On the other hand, Selva et al, 34 comparing bipolar patients with and without a prior history of psychosis did not find a difference in the cognitive performed. We believe that there must be an association between the worse prognosis factors and cognitive performance, although it is not clear how this occurs, and which are the main factors that can influence the decline of cognition.…”

Section: Discussionmentioning

confidence: 90%

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Cognitive impairment in a Brazilian sample of patients with bipolar disorder

Schneider

Candiago

Rosa

et al. 2008

Rev. Bras. Psiquiatr.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 90%

Cognitive impairment in a Brazilian sample of patients with bipolar disorder

Schneider

Candiago

Rosa

et al. 2008

Rev. Bras. Psiquiatr.

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“…The results of this study corroborate previous research and point to the possibility of neuropsychological deficits in impulsive patients with bipolar disorder (Olley et al, 2005;Selva et al, 2007). In particular, this finding agrees with our previous study that used a sample of outpatients with bipolar I disorder where we found that patients with BD were more prone to impulsive results on the CPT-II and the IGT compared to healthy controls.…”

Section: Discussionsupporting

confidence: 93%

Relationship between neuropsychological and clinical aspects and suicide attempts in euthymic bipolar patients

Moraes¹,

Neves²,

Vasconcelos³

et al. 2013

Psicol. Reflex. Crit.

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Some studies have investigated the possible relationship between suicide attempts and impulsivity in patients with bipolar disorder. The objective of this study was to assess the relationship between neuropsychological and clinical aspects and suicide behavior in euthymic bipolar patients. The Iowa Gambling Task and the Conner's Continuous Performance Test evaluated impulsivity in 95 euthymic bipolar patients -42 suicide attempters and 115 normal control participants. A factorial analysis evaluated the adequacy of the instruments. Furthermore, a multiple regression analysis was done in order to develop a model to predict suicide attempts. Our results point to a specific type of impulsivity related to making decisions, lack of planning and borderline personality disorder comorbidity. This type of impulsivity is a risk factor for suicide attempts in patients with bipolar disorder. Keywords: Impulsivity, suicidal behavior, bipolar disorder, decision making. ResumoAlguns estudos investigaram a possível relação entre tentativas de suicídio e impulsividade em pacientes com transtorno bipolar. O objetivo do estudo foi avaliar a relação entre características neuropsicológicas e clínicas e o comportamento suicida em pacientes bipolares eutímicos. Utilizamos o Iowa Gambling Task e o Conner's Continuous Performance Test para avaliar a impulsividade em 95 pacientes eutímicos com transtorno bipolar (42 com tentativas de suicídio) e 155 controles normais. Uma análise fatorial avaliou a adequação dos instrumentos e foi criado um modelo para previsão do número de tentativas de suicídio usando regressão linear múltipla. Nossos resultados apontam para um tipo específico de impulsividade relacionada à tomada de decisões, falta de planejamento e para a comorbidade Transtorno de Personalidade Borderline. A impulsividade por não planejamento é um fator de risco para tentativas de suicídio em pacientes com Transtorno Bipolar. Palavras-chaves: Impulsividade, suicídio, transtorno bipolar, tomada de decisão.

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“…Our results are in line with previous reports showing no significant differences in performance between BPD(+) and BPD(−) on FDS (Glahn et al, 2007;Selva et al, 2007;Martinez-Aran et al, 2008;Savitz et al, 2009;Allen et al, 2010;Brissos et al, 2011) and BDS (Glahn et al, 2007;Selva et al, 2007;Martinez-Aran et al, 2008;Savitz et al, 2009;Allen et al, 2010;Brissos et al, 2011). However, some authors were able to observe differences in cognitive performance between those two groups of patients on these tests (Glahn et al, 2006;Simonsen et al, 2011).…”

Section: Comparison Of Cognitive Performance Between Bpd(+) and Bpd(−supporting

confidence: 93%

Impairments of Working Memory in Schizophrenia and Bipolar Disorder: the Effect of History of Psychotic Symptoms and Different Aspects of Cognitive Task Demands

Hewedi

Frydecka

Moustafa

2015

European Psychiatry

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Comparisons of cognitive impairments between schizophrenia (SZ) and bipolar disorder (BPD) have produced mixed results. We applied different working memory (WM) measures (Digit Span Forward and Backward, Short-delay and Long-delay CPT-AX, N-back) to patients with SZ (n = 23), psychotic BPD (n = 19) and non-psychotic BPD (n = 24), as well as to healthy controls (HC) (n = 18) in order to compare the level of WM impairments across the groups. With respect to the less demanding WM measures (Digit Span Forward and Backward, Short-delay CPT-AX), there were no between group differences in cognitive performance; however, with respect to the more demanding WM measures (Long-delay CPT-AX, N-back), we observed that the groups with psychosis (SZ, psychotic BPD) did not differ from one another, but performed poorer than the group without a history of psychosis (non-psychotic BPD). A history of psychotic symptoms may influence cognitive performance with respect to WM delay and load effects as measured by Long-delay CPT-AX and N-back tests, respectively. We observed a positive correlation of WM performance with antipsychotic treatment and a negative correlation with depressive symptoms in BPD and with negative symptoms in SZ subgroup. Our study suggests that WM dysfunctions are more closely related to a history of psychosis than to the diagnostic categories of SZ and BPD described by psychiatric classification systems.

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Bipolar I patients with and without a history of psychotic symptoms: Do they differ in their cognitive functioning?

Cited by 96 publications

References 40 publications

Cognitive impairment in a Brazilian sample of patients with bipolar disorder

Cognitive impairment in a Brazilian sample of patients with bipolar disorder

Relationship between neuropsychological and clinical aspects and suicide attempts in euthymic bipolar patients

Impairments of Working Memory in Schizophrenia and Bipolar Disorder: the Effect of History of Psychotic Symptoms and Different Aspects of Cognitive Task Demands

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