Bipolar Disorders in a Community Sample of Older Adolescents: Prevalence, Phenomenology, Comorbidity, and Course

Lewinsohn, Peter M.; Klein, Daniel N.; Seeley, John R.

doi:10.1097/00004583-199504000-00012

Cited by 692 publications

(413 citation statements)

References 31 publications

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“…3 This effect is even more common in the pediatric bipolar population, with twice the number of suicide attempts in comparison with individuals with unipolar depression. 4 …”

Section: Introductionmentioning

confidence: 99%

Mood disorders in childhood and adolescence

Rocha

Zeni

Caetano

et al. 2013

Rev. Bras. Psiquiatr.

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The identification and treatment of mood disorders in children and adolescents has grown over the last decades. Major depression is one of the most common and debilitating disorders worldwide, imposing a massive burden to the youth population. Bipolar disorder is being increasingly recognized as having its roots early in life, and its presentation during childhood and adolescence has been submitted to extensive research. This review aims to highlight clinical aspects of the current knowledge on mood disorders in the pediatric population, presenting updated information on epidemiology, diagnostic procedures, and management strategies. Limitations of available evidence and future directions of research in the field are also discussed.

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“…3 This effect is even more common in the pediatric bipolar population, with twice the number of suicide attempts in comparison with individuals with unipolar depression. 4 …”

Section: Introductionmentioning

confidence: 99%

Mood disorders in childhood and adolescence

Rocha

Zeni

Caetano

et al. 2013

Rev. Bras. Psiquiatr.

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“…Juvenile BPD in its various forms affects from 1-4% of pediatric groups (Lewinsohn, et al, 1995) with up to one-fifth of psychiatrically referred children and adolescent psychiatric outpatients manifesting BPD (Weller, et al, 1986, Wozniak, et al, 1995. The literature also documents the concurrent, face, and predictive validity of BPD in childhood (Biederman, et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Further evidence of an association between adolescent bipolar disorder with smoking and substance use disorders: A controlled study

Wilens

Biederman

Adamson

et al. 2008

Drug and Alcohol Dependence

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“…Epidemiological data (Lewinsohn et al 1995), suggest that the prevalence of juvenile-onset BPD may be as common as rates reported in adult populations, although estimates vary widely (Costello et al 1996). Given the increased frequency of lithium use among children and adolescents (Ryan et al 1999) there is a clear need to assess the effects of lithium in pediatric populations.…”

mentioning

confidence: 99%

Decreased Anterior Cingulate Myo-inositol/Creatine Spectroscopy Resonance with Lithium Treatment in Children with Bipolar Disorder

Davanzo

2001

Neuropsychopharmacology

227

130

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This project was designed to compare differences in brain proton spectra between children and adolescents with bipolar disorder (BPD) and gender and age-matched normal controls, and to measure changes in myo-inositol levels following lithium therapy, utilizing in vivo proton magnetic resonance spectroscopy ( 1 H MRS). A single voxel (2x2x2 cm3) was placed in brain anterior (Tondo et al. 1998). Epidemiological data (Lewinsohn et al. 1995), suggest that the prevalence of juvenile-onset BPD may be as common as rates reported in adult populations, although estimates vary widely (Costello et al. 1996). Given the increased frequency of lithium use among children and adolescents (Ryan et al. 1999) there is a clear need to assess the effects of lithium in pediatric populations. Children may have greater lithium resistance than adults (Himmelhoch and Garfinkel 1986;Hsu 1986), and it may take up to six weeks to determine, based on clinical signs and symptoms, whether a child is responding to treatment. Biological markers of treatment response would be extremely useful, particularly in these times of limited inpatient resources. The present study measured the magnetic resonance of myo-inositol and other metabolites with 1 H MRS in pediatric subjects diagnosed with BPD, before and during lithium therapy, with baseline comparison to normal controls individually matched for age and gender. We hypothesized that lithium would have an effect on the :310-825-0469, Fax: 310-206-4446, E-mail: pdavanzo@mednet.ucla.edu Received April 13, 2000; revised August 25, 2000; accepted September 14, 2000. 360 P. Davanzo et al. N EUROPSYCHOPHARMACOLOGY 2001 -VOL . 24 , NO . 4 magnetic resonance of myo-inositol in the anterior cingulate cortex in children with BPD, as measured by in vivo proton magnetic resonance spectroscopy ( 1 H MRS). Secondarily, we postulated that a decrease in myo-inositol signal in response to lithium might be a predictor of treatment efficacy.Lithium has traditionally been the preferred treatment of the manic phase of bipolar illness in adults, children (Geller and Luby 1997), and adolescents (Strober et al. 1995) with BPD. Open-label (Hsu 1986;Carlson et al. 1992;Strober et al. 1995), and one doubleblind placebo-controlled study of adolescents with substance abuse and mania (Geller et al. 1998) suggest that juveniles with BPD may have somewhat reduced benefit from acute lithium therapy compared with adults. Nevertheless, lithium continues to be widely prescribed among children and adolescents with BPD (Geller and Luby 1997) as well as for young patients presenting with excessive irritability (Fava 1997) and extreme affective dysregulation (Vitiello and Stoff 1997).The precise neurobiological mechanisms whereby lithium reduces acute manic excitement and protects against recurrence of illness remain uncertain. It is apparent that lithium exerts an effect on intracellular second-messenger systems in which activated receptorligand complexes stimulate the turnover of inositolcontaining phospholipids (del Rio et ...

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Bipolar Disorders in a Community Sample of Older Adolescents: Prevalence, Phenomenology, Comorbidity, and Course

Cited by 692 publications

References 31 publications

Mood disorders in childhood and adolescence

Mood disorders in childhood and adolescence

Further evidence of an association between adolescent bipolar disorder with smoking and substance use disorders: A controlled study

Decreased Anterior Cingulate Myo-inositol/Creatine Spectroscopy Resonance with Lithium Treatment in Children with Bipolar Disorder

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