Bipolar Disorder: Imaging State Versus Trait

Friedman, Jacqueline N.W.; Hurley, Robin A.; Taber, Katherine H.

doi:10.1176/jnp.2006.18.3.296

Cited by 14 publications

(8 citation statements)

References 38 publications

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“…Functional imaging fi ndings in bipolar affective disorder have been complex, partly due to the fact that there are two poles of illness and partly because some changes appear to be present only during episodes whereas others persist into remission (Friedman et al 2006). Early studies of manic patients found evidence of both decreased and increased activity in the frontal and temporal lobes at rest (for a review see Blumberg et al 2000).…”

Section: Introductionmentioning

confidence: 99%

Failure of de-activation in the medial frontal cortex in mania: evidence for default mode network dysfunction in the disorder

Pomarol‐Clotet

Moro²,

Sarró

et al. 2011

The World Journal of Biological Psychiatry

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Section: Introductionmentioning

confidence: 99%

Failure of de-activation in the medial frontal cortex in mania: evidence for default mode network dysfunction in the disorder

Pomarol‐Clotet

Moro²,

Sarró

et al. 2011

The World Journal of Biological Psychiatry

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“…Some of the limitations inherent to SPECT, such as poor resolution, could have added to these problems. Finally, the confounding effects of medication on rCBF, demonstrated in some of the earlier studies (Goodwin et al 1997;Miller et al 1997;Friedman et al 2006), could not be completed excluded. Future studies should ideally examine drug-free subjects, though this is clearly difficult in this patient population.…”

Section: Methodological Issuesmentioning

confidence: 99%

“…These investigations have suggested that frontal-subcortical circuits comprise the core aspect of the anterior limbic network and that diminished prefrontal modulation of subcortical structures is likely to be the central dysfunction in BD (Strakowski et al 2000(Strakowski et al , 2005. Then again, imaging research in BD has been plagued by several methodological problems such as heterogeneity in designs and patient populations, inconsistent findings and confounding effects of mood state or medication (Friedman et al 2006). Moreover, the number of studies utilizing SPECT is extremely limited.…”

Section: Introductionmentioning

confidence: 99%

A single photon emission computerized tomography (SPECT) study of regional cerebral blood flow in bipolar disorder

Bhardwaj

Chakrabarti

Mittal

et al. 2010

The World Journal of Biological Psychiatry

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Data on functional imaging of bipolar disorder (BD) utilizing single photon emission computerized tomography (SPECT) is limited. This study assessed regional cerebral blood flow (rCBF), using (99m)Tc-ECD SPECT, among patients with BD, with mania (N=10) or depression (N=10), compared with 10 patients with unipolar depression and 10 normal controls. Regions of interest were analysed using a semi-automatic brain quantification programme. Compared to controls, patients with mania had significantly reduced perfusion mainly in the left frontal area, also in the left anterior cingulate and parietal cortices; those with bipolar depression had significantly lowered rCBF principally in the anterior temporal regions bilaterally, as well as the left parietal area. Patients with unipolar depression had significantly lowered perfusion than controls in most of the regions examined, chiefly in the anterior temporal and frontal cortices bilaterally; they also had lowered perfusion in the right anterior temporal and frontal areas, as well as the right middle temporal area and the right thalamus, compared to patients with mania. Increased severity of psychotic symptoms was associated with reduced rCBF in patients. These results indicate that altered blood flow in the frontal-subcortical systems characterises patients with BD, as well as those with unipolar depression.

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“…Bipolar disorder (BD) is a severe psychiatric disorder that affects approximately 2-7% of the general population (Friedman et al 2006). Mania is the defining feature of BD although patients can also manifest depressive symptoms.…”

Section: Modeling Bd Maniamentioning

confidence: 99%

A reverse-translational approach to bipolar disorder: Rodent and human studies in the Behavioral Pattern Monitor

Young

Minassian

Paulus

et al. 2007

Neuroscience & Biobehavioral Reviews

105

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Mania is the defining feature of Bipolar Disorder (BD). There has been limited progress in understanding the neurobiological underpinnings of BD mania and developing novel therapeutics, in part due to a paucity of relevant animal models with translational potential. Hyperactivity is a cardinal symptom of mania, traditionally measured in humans using observer-rated scales. Multivariate assessment of unconditioned locomotor behavior using the rat Behavioral Pattern Monitor (BPM) developed in our laboratory has shown that hyperactivity includes complex multifaceted behaviors. The BPM has been used to demonstrate differential effects of drugs on locomotor activity and exploratory behavior in rats. Studies of genetically engineered mice in a mouse BPM have confirmed its utility as a cross-species tool. In a "reverse-translational" approach to this work, we developed the human BPM to characterize motor activity in BD patients. Increased activity, object interactions, and altered locomotor patterns provide multidimensional phenotypes to model in the rodent BPM. This unique approach to modeling BD provides an opportunity to identify the neurobiology underlying BD mania and test novel antimanic agents. KeywordsBipolar Disorder; mania; locomotor activity; exploratory; rat; mouse; Behavioral Pattern Monitor; Open Field; hyperactivity Modeling BD maniaBipolar disorder (BD) is a severe psychiatric disorder that affects approximately 2-7% of the general population (Friedman et al. 2006). Mania is the defining feature of BD although patients can also manifest depressive symptoms. During the manic episodes of BD, patients exhibit impulsive behavior, hypersexuality, pressured speech, flight of ideas, and motor hyperactivity, which have been conceptualized as inhibitory failures of behavior and thought (Goodwin and Jamison 1990). These symptoms profoundly impair and disrupt social, occupational, and family life in individuals with BD (Post et al. 2003). Despite the prevalence of this disorder, surprisingly few studies (Franks et al. 1983,Gooding and Tallent 2001,Murphy et al. 1999, have attempted to develop adequate translational models to elucidate the neurobiology * Correspondence should be sent to: Martin P. Paulus, M.D. Department of Psychiatry, UCSD, La Jolla, California, 92093-9116 Phone: (858) Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public Access Author ManuscriptNeurosci Biobehav Rev. Author manuscript; available in PMC 2008 January 1. Published in final edited form as:Neurosci Biobehav Rev. 2007 ; 31(6): 882-896. NIH-PA Author ManuscriptNIH-PA Author Manu...

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Bipolar Disorder: Imaging State Versus Trait

Cited by 14 publications

References 38 publications

Failure of de-activation in the medial frontal cortex in mania: evidence for default mode network dysfunction in the disorder

Failure of de-activation in the medial frontal cortex in mania: evidence for default mode network dysfunction in the disorder

A single photon emission computerized tomography (SPECT) study of regional cerebral blood flow in bipolar disorder

A reverse-translational approach to bipolar disorder: Rodent and human studies in the Behavioral Pattern Monitor

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