Bipolar disorder comorbidity in patients with obsessive-compulsive disorder: Prevalence and predictors

Domingues-Castro, Mariana S.; Torresan, Ricardo Cézar; Shavitt, Roseli G.; Fontenelle, Leonardo F.; Ferrão, Ygor Arzeno; Rosário, Maria Conceição do; Torres, Albina Rodrigues

doi:10.1016/j.jad.2019.06.018

Cited by 11 publications

(16 citation statements)

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“…Studies on possible associations suggest that OCD often occurs after the onset of bipolar disorder, with obsessive–compulsive symptoms typically worsening during depressive episodes and improving during manic episodes (Amerio et al, 2015; Perugi et al, 2002). The fact that panic disorder and/or agoraphobia was also prevalent (albeit not exclusively) in this particular subgroup is in line with previous research that suggests that the presence of panic disorder with agoraphobia was predictive of bipolar disorder comorbidity in adult patients with OCD (Domingues‐Castro, Torresan, & Shavitt, 2019). In this context, it is important to note that all subjects included in our sample were actively seeking treatment and were referred to one of the contributing mental health centers with OCD as their primary (suspected) diagnosis.…”

Section: Discussionsupporting

confidence: 89%

Classification of comorbidity in obsessive–compulsive disorder: A latent class analysis

et al. 2020

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Objective Patients with OCD differ markedly from one another in both number and kind of comorbid disorders. In this study, we set out to identify and characterize homogeneous subgroups of OCD patients based on their comorbidity profile. Methods In a cohort of 419 adult subjects with OCD, the lifetime presence of fifteen comorbid disorders was assessed. Latent class analysis was used to identify comorbidity‐based subgroups. Groups were compared with regard to core clinical characteristics: familiality, childhood trauma, age at onset, illness severity, OCD symptom dimensions, personality characteristics, and course of illness. Results The study sample could be divided in a large group ( n = 311) with a low amount of comorbidity that could be further subdivided into two subgroups: OCD simplex ( n = 147) and OCD with lifetime major depressive disorder ( n = 186), and a group ( n = 108) with a high amount of comorbidity that could be further subdivided into a general anxiety‐related subgroup ( n = 49), an autism/social phobia‐related subgroup ( n = 27), and a psychosis/bipolar‐related subgroup ( n = 10). Membership of the high‐comorbid subgroup was associated with higher scores on childhood trauma, illness severity, and the aggression/checking symptom dimension and lower scores on several personality characteristics. Conclusion Grouping OCD patients based on their comorbidity profile might provide more homogeneous, and therefore, more suitable categories for future studies aimed at unraveling the etiological mechanisms underlying this debilitating disorder.

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Section: Discussionsupporting

confidence: 89%

Classification of comorbidity in obsessive–compulsive disorder: A latent class analysis

et al. 2020

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“…Participants who answered "yes" were considered as having suicidal ideation. Several studies have used this method for suicidal ideation measurement (27)(28)(29)(30)(31).…”

Section: Suicidal Ideationmentioning

confidence: 99%

The Mediating Effect of Depression on the Relation Between Interpersonal Needs and Suicidal Ideation Among Chinese Transgender Women

Chang

Zeng

Qiao

et al. 2022

Front. Public Health

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BackgroundTransgender women are at high risk of depression and suicidal ideation. The interpersonal theory of suicide proposes that suicidal ideation could be a consequence of high interpersonal needs (thwarted belongingness and perceived burdensomeness). The current study tests this theory and investigates whether depression could mediate the relationship between interpersonal needs and suicidal ideation among transgender women in Shenyang, China.MethodsA total of 198 transgender women were recruited by snowball sampling. A cross-sectional study was conducted through a structured questionnaire. Suicidal ideation, depression, and interpersonal needs were assessed. Path analysis was used to carry out the research goals and the mediating effect of depression was tested.ResultsThere were nearly 37% of the participants reported lifetime suicidal ideation. Suicidal ideation was positively correlated with thwarted belongingness (t = −5.53, p < 0.01) and perceived burdensomeness (t = −5.02, p < 0.01). The direct effect from thwarted belongingness to suicidal ideation via depression was statistically significant (Std. β = 0.232, p < 0.01). Depression could also mediate the indirect path from perceived burdensomeness to suicidal ideation through depression (Std. β = 0.222, p < 0.01) although the direct path between them was not significant (Std. β = 0.046, p = 0.693).ConclusionsDepression fully mediated the relationship between perceived burdensomeness and suicidal ideation, and partially mediate the relationship between thwarted belongingness and suicidal ideation. To reduce the risk of suicidal ideation among transgender women, interventions targeting thwarted belongingness, perceived burdensomeness, and depression are needed.

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“…De maneira semelhante, um estudo com 605 indivíduos com TOC divididos em 03 grupos (com TB comórbido, com transtorno depressivo maior comórbido e sem transtorno afetivo) não encontrou diferença na idade média de início dos SOC [4]. Um estudo brasileiro, com 995 pacientes com TOC, tampouco encontrou diferença na idade de início dos SOC entre os sujeitos com e sem TB comórbido [3].…”

Section: Características Clínicas Do Toc Associado Ao Tbunclassified

“…Entre os pacientes com TOC, a prevalência de TB é estimada em 18% [1]. A comorbidade TB-TOC pode estar associada, comparativamente ao TB e ao TOC não comórbidos, à sintomatologia e evolução diferenciadas [2], com maior incidência de transtornos ansiosos comórbidos, maior incidência de comportamentos suicidas [3] e maior prejuízo funcional [3,4].…”

Section: Introductionunclassified

Comorbidade entre transtorno bipolar e transtorno obsessivo-compulsivo: aspectos epidemiológicos, clínicos e terapêuticos.

Silva¹,

Calil

Boaventura

et al. 2022

Debates em Psiquiatria

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Introdução: O transtorno bipolar (TB) e o transtorno obsessivo-compulsivo (TOC) são altamente comórbidos. Esta comorbidade está associada a impacto clínico significativo. Este artigo revisa os dados disponíveis sobre aspectos epidemiológicos, características clínicas e opções de tratamento da comorbidade TB-TOC. Métodos: Foi realizada revisão bibliográfica não sistemática na base de dados PUBMED, no idioma inglês. As seguintes palavras-chave foram incluídas na busca: obsessive-compulsive disorder, bipolar disorder, comorbidity. Resultados: Entre as amostras de pacientes com TB, a prevalência de TOC comórbido foi estimada em cerca de 17%. Entre as amostras de pacientes com TOC, a prevalência de TB foi estimada em, aproximadamente, 18%. Os dados sobre a validade diagnóstica da comorbidade são limitados. Os pacientes com TB-TOC parecem apresentar curso episódico dos sintomas obsessivo-compulsivos (SOC) com maior frequência do que os pacientes com TOC sem TB. A comorbidade parece estar associada à maior número total de episódios depressivos e à ocorrência mais frequente de comportamentos suicidas. Conteúdos obsessivos de simetria, agressão, religiosidade e acumulação parecem ser mais frequentes em pacientes com TB-TOC. O uso de estabilizadores do humor é a principal estratégia de tratamento. Conclusão: A prevalência da comorbidade parece ser relevante. O TB-TOC pode estar associado à caracteristicas clínicas particulares. Os dados sobre a validade diagnóstica da comorbidade são inconclusivos. A estabilização do humor é o primeiro objetivo no manejo clínico.

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Bipolar disorder comorbidity in patients with obsessive-compulsive disorder: Prevalence and predictors

Cited by 11 publications

References 50 publications

Classification of comorbidity in obsessive–compulsive disorder: A latent class analysis

Classification of comorbidity in obsessive–compulsive disorder: A latent class analysis

The Mediating Effect of Depression on the Relation Between Interpersonal Needs and Suicidal Ideation Among Chinese Transgender Women

Comorbidade entre transtorno bipolar e transtorno obsessivo-compulsivo: aspectos epidemiológicos, clínicos e terapêuticos.

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