Bipolar disorder and white matter microstructure: ENIGMA bipolar disorder fractional anisotropy DTI results

Pauling, Melissa; Henry, Chantal; Sarrazin, Sophie; Duchesnay, Édouard; Stout, Julie C.; Hibar, Derrek P.; Jahanshad, Neda; Andreassen, Ole A.; Thompson, Paul M.; Houenou, Josselin

doi:10.1016/s0924-977x(17)31511-0

Cited by 3 publications

(2 citation statements)

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“…An increasing number of studies have applied DTI to investigate major depressive disorder (MDD) and bipolar disorder (BD). Abnormal white matter integrity has been shown to play an essential role in the pathophysiology of MDD 2–6 and BD 7–9 . However, common or disease‐specific mechanisms of white matter degeneration among the two disorders remain to be elucidated.…”

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confidence: 99%

Age‐related white matter changes revealed by a whole‐brain fiber‐tracking method in bipolar disorder compared to major depressive disorder and healthy controls

Masuda

Okada

Takamura

et al. 2020

Psychiatry Clin Neurosci

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Aim Several studies have reported altered age‐associated changes in white matter integrity in bipolar disorder (BD). However, little is known as to whether these age‐related changes are illness‐specific. We assessed disease‐specific effects by controlling for age and investigated age‐associated changes and Group × Age interactions in white matter integrity among major depressive disorder (MDD) patients, BD patients, and healthy controls. Methods Healthy controls (n = 96; age range, 20–77 years), MDD patients (n = 101; age range, 25–78 years), and BD patients (n = 58; age range, 22–76 years) participated in this study. Fractional anisotropy (FA) derived from diffusion tensor imaging in 54 white matter tracts were compared after controlling for the linear and quadratic effect of age using a generalized linear model. Age‐related effects and Age × Group interactions were also assessed in the model. Results The main effect of group was significant in the left column and body of the fornix after controlling for both linear and quadratic effects of age, and in the left body of the corpus callosum after controlling for the quadratic effect of age. BD patients exhibited significantly lower FA relative to other groups. There was no Age × Group interaction in the tracts. Conclusion Significant FA reductions were found in BD patients after controlling for age, indicating that abnormal white matter integrity in BD may occur at a younger age rather than developing progressively with age.

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confidence: 99%

Age‐related white matter changes revealed by a whole‐brain fiber‐tracking method in bipolar disorder compared to major depressive disorder and healthy controls

Masuda

Okada

Takamura

et al. 2020

Psychiatry Clin Neurosci

View full text Add to dashboard Cite

show abstract

“…Patients with MDD and BD show abnormal white matter integrity across multiple white matter tracts including the cingulate bundle, corpus callosum, and the superior longitudinal fasciculus (Bracht et al., 2015a; Chen et al., 2016; Duarte et al., 2016; Kelly et al., 2017; Liao et al., 2013; Nortje et al., 2013; Pauling et al., 2017). These abnormalities are thought to be associated with cognitive impairments (Alves et al., 2012; Bauer et al., 2015; Dalby et al., 2012; Kafantaris et al., 2009; Knöchel et al., 2016; Li et al., 2014; Linke et al., 2013; Liu et al., 2010; Magioncalda et al., 2016; McKenna et al., 2015; Murphy et al., 2007; Oertel‐Knöchel et al., 2014; Poletti et al., 2015; Rizk et al., 2017; Yin et al., 2016).…”

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confidence: 99%