Bipolar disorder and its relation to major psychiatric disorders: a family‐based study in the <scp>S</scp>wedish population

Song, Jie; Bergen, Sarah E.; Kuja‐Halkola, Ralf; Larsson, Henrik; Landén, Mikael; Lichtenstein, Paul

doi:10.1111/bdi.12242

Cited by 127 publications

(107 citation statements)

References 38 publications

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“…The heritability of BD ranges from 58 [59] to 85 % [60]. Adoption and twin studies estimate that 60-80 % of the risk for ADHD is heritable, likely reflecting a polygenic or oligogenic risk mechanism [61].…”

Section: Family Historymentioning

confidence: 99%

Bipolar Disorder and ADHD: Comorbidity and Diagnostic Distinctions

Marangoni¹,

Chiara²,

Faedda

2015

Curr Psychiatry Rep

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Attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BD) are neurodevelopmental disorders with onset in childhood and early adolescence, and common persistence in adulthood. Both disorders are often undiagnosed, misdiagnosed, and sometimes over diagnosed, leading to high rates of morbidity and disability. The differentiation of these conditions is based on their clinical features, comorbidity, psychiatric family history course of illness, and response to treatment. We review recent relevant findings and highlight epidemiological, clinical, family history, course, and treatment-response differences that can aid the differential diagnosis of these conditions in an outpatient pediatric setting.

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Section: Family Historymentioning

confidence: 99%

Bipolar Disorder and ADHD: Comorbidity and Diagnostic Distinctions

Marangoni¹,

Chiara²,

Faedda

2015

Curr Psychiatry Rep

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“…Twin and family studies have consistently demonstrated that psychotic disorders, substance misuse and violent crime aggregate in families, in large part due to genetic influences (11-13). The genetic architecture of psychotic disorders is characterized by considerable pleiotropy, as evidenced by large-scale quantitative genetic studies, suggesting that approximately half of the genetic influences increasing the liabilities of developing schizophrenia and bipolar disorder may be shared (11).…”

mentioning

confidence: 99%

Genetic and environmental determinants of violence risk in psychotic disorders: a multivariate quantitative genetic study of 1.8 million Swedish twins and siblings

2015

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Patients diagnosed with psychotic disorders (e.g., schizophrenia and bipolar disorder) have elevated risks of committing violent acts, particularly if they are comorbid with substance misuse. Despite recent insights from quantitative and molecular genetic studies demonstrating considerable pleiotropy in the genetic architecture of these phenotypes, there is currently a lack of large-scale studies that have specifically examined the etiological links between psychotic disorders and violence. Using a sample of all Swedish individuals born between 1958-1989 (n=3,232,010), we identified a total of 923,259 twin-sibling pairs. Patients were identified using the National Patient Register using validated algorithms based on ICD 8-10. Univariate quantitative genetic models revealed that all phenotypes (schizophrenia, bipolar disorder, substance misuse and violent crime) were highly heritable (h2=53-71%). Multivariate models further revealed that schizophrenia was a stronger predictor of violence (r=0.32; 95% CI: 0.30-0.33) than bipolar disorder (r=0.23; 0.21-0.25) and large proportions (51%-67%) of these phenotypic correlations were explained by genetic factors shared between each disorder, substance misuse and violence. Importantly, we found that genetic influences that were unrelated to substance misuse explained approximately a fifth (21%; 20%-22%) of the correlation with violent criminality in bipolar disorder but none of the same correlation in schizophrenia (pbipolar disorder<0.001; pschizophrenia=0.55). These findings highlight the perils of not disentangling common and unique sources of covariance across genetically similar phenotypes as the latter sources may include etiologically important clues. Clinically, these findings underline the importance of assessing risk of different phenotypes together and integrating interventions for psychiatric disorders, substance misuse and violence.

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“…This seems to have been the case, for instance, in the population-wide family history study of bipolar disorder in Sweden. 8 Here, the relative risks of various psychiatric conditions were increased among relatives of bipolar probands, but their values were lower than the relative risks for comorbidities in probands.…”

Section: J Psychiatry Neurosci 2017;42(5)mentioning

confidence: 73%

Psychiatric genetics — Does diagnosis matter?

Alda

2017

JPN

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Bipolar disorder and its relation to major psychiatric disorders: a family‐based study in the Swedish population

Cited by 127 publications

References 38 publications

Bipolar Disorder and ADHD: Comorbidity and Diagnostic Distinctions

Bipolar Disorder and ADHD: Comorbidity and Diagnostic Distinctions

Genetic and environmental determinants of violence risk in psychotic disorders: a multivariate quantitative genetic study of 1.8 million Swedish twins and siblings

Psychiatric genetics — Does diagnosis matter?

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