Bipolar Disorder and Gender Are Associated with Frontolimbic and Basal Ganglia Dysconnectivity: A Study of Topological Variance Using Network Analysis

Nabulsi, Leila; McPhilemy, Genevieve; Kilmartin, Liam; O’Hora, Denis; O’Donoghue, Stefani; Forcellini, Giulia; Najt, Pablo; Ambati, Srinath; Costello, Laura; Byrne, Fintan; McLoughlin, James; Hallahan, Brian; McDonald, Colm; Cannon, Dara M.

doi:10.1089/brain.2019.0667

Cited by 13 publications

(4 citation statements)

References 57 publications

(115 reference statements)

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“…Some anatomical studies report volumetric alterations in the cerebellum in BD [8]. Network-level analyses in BD suggest impaired microstructural organization in posterior-parietal regions, whereby the cerebellum was found to be less frequently involved in BD rich club membership [14]. Rich-club members are found in topologically central regions that are critical for global integration and coordination of higher cognitive processes within the brain’s networks [35].…”

Section: Discussionmentioning

confidence: 99%

“…Graph-theory tools have been applied to whole-brain networks, with findings consistent with morphological disturbances in the corpus callosum, implicating inter-hemispheric structural dysconnectivity. Local structural and functional network alterations have been reported in prefrontal and limbic areas [6], [14], [15]. Network-based analyses (structural and functional) have also highlighted disturbances in broader circuit and network mechanisms that integrate cognitive control, affective and reward-systems of the brain [16]- [18].…”

Section: Introductionmentioning

confidence: 99%

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Along-Tract Statistical Mapping of Microstructural Abnormalities in Bipolar Disorder: A Pilot Study

Nabulsi

Chandio

Dhinagar

et al. 2023

Preprint

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Investigating brain circuitry involved in bipolar disorder (BD) is key to discovering brain biomarkers for genetic and interventional studies of the disorder. Even so, prior research has not provided a fine-scale spatial mapping of brain microstructural differences in BD. In this pilot diffusion MRI dataset, we used BUndle ANalytics (BUAN), a recently developed analytic approach for tractography, to extract, map, and visualize the profile of microstructural abnormalities on a 3D model of fiber tracts in people with BD (N=38) and healthy controls (N=49), and investigate along-tract white matter (WM) microstructural differences between these groups. Using the BUAN pipeline, BD was associated with lower mean Fractional Anisotropy (FA) in fronto-limbic and interhemispheric pathways and higher mean FA in posterior bundles relative to controls. BUAN combines tractography and anatomical information to capture distinct along-tract effects on WM microstructure that may aid in classifying diseases based on anatomical differences.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Along-Tract Statistical Mapping of Microstructural Abnormalities in Bipolar Disorder: A Pilot Study

Nabulsi

Chandio

Dhinagar

et al. 2023

Preprint

Self Cite

View full text Add to dashboard Cite

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“…Each site had unique acquisition parameters (gradient directions range=30-64, and b-values=1000-1200 s/mm 2 ). For details of acquisition parameters and socio-demographic data from these sites, please see [16][17][18][19][20]. All raw data was visually inspected to check for problems in image acquisition, including movement, susceptibility, and noise artifacts.…”

Section: Methodsmentioning

confidence: 99%

Multi-Site Statistical Mapping of Along-Tract Microstructural Abnormalities in Bipolar Disorder with Diffusion MRI Tractometry

Nabulsi,

Chandio,

McPhilemy

et al. 2023

Preprint

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Investigating alterations in brain circuitry associated with bipolar disorder (BD) may offer a valuable approach to discover brain biomarkers for genetic and interventional studies of the disorder and related mental illnesses. Some diffusion MRI studies report evidence of microstructural abnormalities in white matter regions of interest, but we lack a fine-scale spatial mapping of brain microstructural differences along tracts in BD. We also lack large-scale studies that integrate tractometry data from multiple sites, as larger datasets can greatly enhance power to detect subtle effects and assess whether effects replicate across larger international datasets. In this multisite diffusion MRI study, we used BUndle ANalytics (BUAN, Chandio 2020), a recently developed analytic approach for tractography, to extract, map, and visualize profiles of microstructural abnormalities on 3D models of fiber tracts in 148 participants with BD and 259 healthy controls from 6 independent scan sites. Modeling site differences as random effects, we investigated along- tract white matter (WM) microstructural differences between diagnostic groups. QQ plots showed that group differences were gradually enhanced as more sites were added. Using the BUAN pipeline, BD was associated with lower mean fractional anisotropy (FA) in fronto-limbic, interhemispheric, and posterior pathways; higher FA was also noted in posterior bundles, relative to controls. By integrating tractography and anatomical information, BUAN effectively captures unique effects along white matter (WM) tracts, providing valuable insights into anatomical variations that may assist in the classification of diseases.

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“…Furthermore, evidence has shown that aberrant immune signaling contributes to all stages of BD, and also to metabolic disturbance 5,6 . Recent structural and functional studies have directly implicated reward system dysregulation in BD [7][8][9] , and evidence has shown that core network functional abnormalities lead to aberrant reward-processing, and the neural circuitry in BD is highly associated with systemic inflammation 10,11 . Such systemic inflammation might drive changes in dopaminergic corticostriatal circuitry connectivity 12,13 , and a recent large-scale study indicated that both BD and body mass index (BMI) were associated with similar regional brain volumes, including that of the basal ganglia 14 .Leptin is secreted by white adipose tissue and regulates energy homeostasis.…”

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confidence: 99%

Associations of leptin and corticostriatal connectivity in bipolar disorder

Wei

Tseng

Chang

et al. 2022

Sci Rep

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Bipolar disorder (BD) and metabolic disturbance represent a chronic state of low-grade inflammation and corticostriatal circuitry alterations. Herein, we aimed to investigate whether plasma leptin, an adipokine that plays a key role in the interplay of metabolism and inflammation, is associated with corticostriatal connectivity in patients with BD. Twenty-eight BD I patients, 36 BD II patients and 66 healthy controls were enrolled and completed the Hamilton Depression Rating Scale, the Young Mania Rating Scale, and the Recent Life Change Questionnaire. Fasting plasma leptin and C-reactive protein (CRP) levels were measured, and corticostriatal connectivity was examined using functional magnetic resonance imaging (fMRI). The relationships between leptin, CRP and body mass index (BMI) identified in the controls and BD II patients were absent in the BD I patients. We did not find a significant group difference in the leptin level; nevertheless, the negative correlation between leptin level and corticostriatal connectivity (ventrolateral prefrontal cortex and inferior temporal gyrus) observed in the healthy controls was absent in the BD patients. The disproportionate increase in leptin level with increasing BMI in BD indicated a potential inflammatory role of white adipose tissue in BD. Furthermore, higher CRP levels in BD I patients might induce leptin resistance. Collectively, our results implied vulnerability to inflammatory and metabolic diseases in patients with BD, especially BD I.

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Bipolar Disorder and Gender Are Associated with Frontolimbic and Basal Ganglia Dysconnectivity: A Study of Topological Variance Using Network Analysis

Cited by 13 publications

References 57 publications

Along-Tract Statistical Mapping of Microstructural Abnormalities in Bipolar Disorder: A Pilot Study

Along-Tract Statistical Mapping of Microstructural Abnormalities in Bipolar Disorder: A Pilot Study

Multi-Site Statistical Mapping of Along-Tract Microstructural Abnormalities in Bipolar Disorder with Diffusion MRI Tractometry

Associations of leptin and corticostriatal connectivity in bipolar disorder

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