Biphasic vs basal bolus insulin regimen in Type 2 diabetes: a systematic review and meta‐analysis of randomized controlled trials

Abstract

Biphasic and basal bolus regimens were equally effective in reducing HbA1c in insulin naïve patients with Type 2 diabetes and both regimens are equally effective for initiating insulin in Type 2 diabetes.

Premixed insulin regimens for type 2 diabetes

“…Finally, in a subgroup analysis in insulin-naïve patients, premixed regimen had no difference with basal-bolus regimens (-0.15 %; -0.52 to 0.22) [11].…”

“…Similarly, the recently published GALAPA-GOS study demonstrated that in insulin-naive patients, premixed insulin once or twice daily reduced HbA 1c by a further 0.16 % (confidence interval 0.04 to 0.27) compared with insulin glargine with or without insulin glulisine [10]. Finally, in a subgroup analysis in insulin-naïve patients, premixed regimen had no difference with basal-bolus regimens (-0.15 %; -0.52 to 0.22) [11].For patients already on basal insulin, results from the LanScape study suggested that basal-plus regimens (glargine plus insulin glulisine once daily) are non-inferior to premixed insulin (biphasic insulin aspart 30 twice daily) in reducing HbA 1c [12]. However, a recent meta-analysis by Wang et al concluded that basal-bolus regimens have superior glycemic efficacy to premix insulin in non-insulinnaïve patients (-0.22 %; -0.42 to -0.02) [11].…”

“…Similarly, the recently published GALAPA-GOS study demonstrated that in insulin-naive patients, premixed insulin once or twice daily reduced HbA 1c by a further 0.16 % (confidence interval 0.04 to 0.27) compared with insulin glargine with or without insulin glulisine [10]. Finally, in a subgroup analysis in insulin-naïve patients, premixed regimen had no difference with basal-bolus regimens (-0.15 %; -0.52 to 0.22) [11].…”

“…However, a recent meta-analysis by Wang et al concluded that basal-bolus regimens have superior glycemic efficacy to premix insulin in non-insulinnaïve patients (-0.22 %; -0.42 to -0.02) [11]. Findings…”

“…However, a recent meta-analysis by Wang et al concluded that basal-bolus regimens have superior glycemic efficacy to premix insulin in non-insulinnaïve patients (-0.22 %; -0.42 to -0.02) [11]. Findings from the latest analysis by Giugliano et al suggest that this difference in favor of basal-bolus regimens is probably associated with the regimens compared, and is verified only when full basal-bolus regimens are compared with twicedaily premixed insulin [7].…”