Biphasic Synovial Sarcoma of the Extremity: Quadruple Approach of Isolated Limb Perfusion, Surgical Ablation, Adipofascial Perforator Flap and Radiation to Avoid Amputation

Steinstraesser, Lars; Agarwal, Reena; Stricker, Ingo; Steinau, Hans-Ulrich; Al-Benna, Sammy

doi:10.1159/000327845

Cited by 7 publications

(8 citation statements)

References 14 publications

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“…Despite its name, synovial sarcomas do not arise from synovium and rarely occur in the joints. A microscopic similarity to the primitive synovium was observed early in the literature, but its histogenesis is still unclear [6,14]. Nevertheless, the term synovial sarcoma continues to be used.…”

Section: Discussionmentioning

confidence: 98%

“…Our literature search started from 1983 in order to include a paper from 1983 (Kinsella et al [22]), which was not reported in Dreyfuss's review. One hundred and eightynine cases of synovial sarcoma of the hand-wrist have been recorded [6,8,10,12,13, during the past 37 years ( Table 1). Among these, 57 cases in the hand-wrist where demographic, pathologic, and clinical information was available were analyzed ( Table 2).…”

Section: Discussionmentioning

confidence: 99%

“…This neoplasm can occur in almost any location in the body. In the vast majority of cases, it involves deep soft tissue of the lower extremities, frequently in the vicinity of large joints, like the knee and ankle [6]. It can also occur in viscera (heart, lung, pleura, kidney), oral cavity, mediastinum, retroperitoneum, peritoneum, central nervous system, and peripheral nerves.…”

Section: Introductionmentioning

confidence: 99%

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Synovial sarcoma of the hand-wrist: a case report and review of the literature

2021

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Background Synovial sarcomas are infrequent malignant tumors occurring mostly in adolescents and young adults. The occurrence of synovial sarcoma in the hand-wrist area is rare (4 to 8.5% of all synovial sarcomas in different studies). Case presentation This report documents an uncommon case of synovial sarcoma occurring in the hand-wrist of a 69-year-old Caucasian woman. She was subsequently treated with surgical excision and radiotherapy without recurrence after follow up. Conclusions This paper aims to characterize the demographic, pathologic, and clinical features with a literature review. The present literature review confirms that hand-wrist synovial sarcomas are more frequent among males and subjects 10 to 40 years old. Most cases in this location are usually not larger than 5 cm in size. The five-year survival rate is higher than that reported in a previous review on hand synovial sarcomas, and this suggests an improved survival in recent decades.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synovial sarcoma of the hand-wrist: a case report and review of the literature

2021

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“…Overall, benign tumors should be treated with a marginal excision, whereas malignant tumors should be widely excised. It is important to obtain adequate ablative margins and prevent local recurrence in patients with synovial sarcoma [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Synovial sarcoma of the buttocks presenting with a non-healing wound and rapid progression after local resection: a case report

et al. 2012

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Synovial sarcoma is a malignant mesenchymal neoplasm that is frequently misdiagnosed as a benign condition because of its small size, slow growth, and well-delineated appearance. Rapid spread and early death occur rarely. Here we report a case of synovial sarcoma of the buttocks presenting with a non-healing wound and rapid progression after local resection in a 23-year-old woman. She initially found a slightly painful subcutaneous mass in the left buttock and underwent local excision. Postoperatively, she developed a non-healing wound that did not respond to conventional antibiotic therapy and local wound care, and pitting edema of the lower extremities. A magnetic resonance imaging scan revealed a large heterogeneous, irregular mass in the buttocks with regional lymph node involvement. Histological and immunohistochemical analyses suggested the diagnosis of a poorly differentiated synovial sarcoma. Her condition deteriorated dramatically shortly thereafter; she developed systemic edema and died of respiratory failure. This case suggests that synovial sarcoma may be fatal within months of recognition if improperly managed and stresses the importance of adequate pre-surgical evaluation and postoperative pathological analysis in the management of a subcutaneous mass.

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“…7 Thus, once high closing tensions are reached, very little additional tissue can be recruited for wound closure, and other solutions, such as flaps or grafts, should be considered. [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] Tension is an important variable in wound healing. [1][2][3] Increased tension leads to compromised circulation, wound dehiscence, necrosis, suture cutout, and slow wound healing.…”

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confidence: 99%