Biphasic pulp blood-flow response to substance P in the dog as measured with a radiolabelled, microsphere injection method

Kim, Sungpyo; Dörscher-Kim, J.; Liu, M.-T.; Trowbridge, Henry O.

doi:10.1016/0003-9969(88)90062-3

Cited by 27 publications

(5 citation statements)

References 20 publications

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“…3-morpholinosydnonimine, the low-compliance system does not compress the pulp vessels and thus does not affect the local vasodilation induced by this agent. Our results showed decreased dental pulp vascular resistance and unchanged dental pulp blood flow values instead of an increase in dental pulp vascular resistance and a decrease in dental pulp blood flow (Kim et al, 1988). The percent fractional cardiac output in 3-morpholinosydnonimine group is 111 + 27%, indicating that, similarly to the NG-nitro-Larginine experiment, the dental fraction of cardiac output remains unchanged after 3-morpholinosydnonimine, since neither cardiac output nor dental blood flow changed significantly.…”

Section: Discussioncontrasting

confidence: 53%

Evidence for the Role of Nitric Oxide in the Circulation of the Dental Pulp

et al. 1995

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Many authors have studied the hemodynamics of the dental pulp; however, there are scarcely any data regarding the involvement of the L-arginine/nitric oxide pathway in the regulatory mechanism. Thus, we have examined the physiological effects of (1) NG-nitro-L-arginine as an inhibitor of nitric oxide synthesis and (2) the nitric oxide donor 3-morpholinosydnonimine on blood flow and vascular resistance in the canines of anesthetized cats to study the potential involvement of nitric oxide in the regulation of dental vascular homeostasis. Mean arterial blood pressure, heart rate, blood gases, pH, cardiac output, and tissue blood flow were determined prior to and 15 min after i.v. administration of either NG-nitro-L-arginine (30 mg/kg, n = 9) or 3-morpholinosydnonimine (1 mg/kg, n = 7). Blood flow was measured by radioactive-labeled microspheres. There were no significant differences in baseline parameters between the two groups of cats. The dental pulp blood flow decreased to 53 +/- 13% (p < 0.01) of the control level after NG-nitro-L-arginine administration, while it decreased only slightly (to 82 +/- 12%) after 3-morpholinosydnonimine administration. The dental pulp's vascular resistance increased to 367 +/- 69% (p < 0.01) of the control level after NG-nitro-L-arginine, while it decreased to 73 +/- 10% (p < 0.05) of control after 3-morpholinosydnonimine. We found that the L-arginine/nitric oxide pathway plays an important role in the regulation of pulpal blood circulation.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussioncontrasting

confidence: 53%

Evidence for the Role of Nitric Oxide in the Circulation of the Dental Pulp

et al. 1995

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“…Initial vasodilation of pulpal arterioles leads to an increase in pulpal interstitial pressure, which leads to a collapse of pulpal venules [33][34][35] . By the study of Kim et al 8) , immediately after SP injection, PBF increased significantly, which was followed by decrease after 30 sec of SP injection. The same phenomenon was shown in the present study.…”

Section: ⅳ Discussionmentioning

confidence: 90%

“…Therefore it is known to play an important part in vasoregulation: it is a strong vasodilator and increasing vascular permeability 6,8) and also involved in nociception (pain) associated with inflammation 9) . SP showed to exert flow response on the dental pulp 8) . With the use of electrical stimulation, the vasodilation in the pulp was proposed to be caused by liberation of sensory neuropeptides 6) .…”

mentioning

confidence: 99%

Local application of NK1 receptor antagonists and pulpal blood flow in cat

Kim

Chu

Lee

et al. 2004

J Korean Acad Conserv Dent

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“…Although it is generally accepted that assessment of the dental pulp blood supply (pulp vitality) may be the only available true indicator of pulpal health (Baumgardner et al., 1996; Goh et al., 2022; Hori et al., 2011; Kim et al., 1988; Peterson et al., 1999), the most commonly used clinical tests for assessing pulp status are pulp sensibility tests, such as thermal and electric tests (TPT and EPT). Nevertheless, there are other tests that directly assess blood flow within dental pulp such as laser Doppler flowmetry (LDF) and pulse oximetry (PO) (Jafarzadeh & Abbott, 2010).…”

Section: Discussionmentioning

confidence: 99%

The clinical outcomes of vital intact teeth close to large cystic lesions of endodontic origin: A prospective clinical study

Erovigni,

Bosso,

Alovisi

et al. 2024

Int Endodontic J

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AimTo evaluate the indication of the endodontic treatment for vital intact teeth with the root apex involved in large radicular cystic lesions of endodontic origin.MethodologyThis prospective cohort study enrolled healthy participants with radicular cysts of endodontic origin and with the root apex of vital intact teeth involved in the bone defect, as determined by cone beam computed tomography (CBCT). Thirty‐two sound vital teeth were analysed by thermal (TPT) and electric pulp tests (EPT) before surgery (T0) and 1 week (T1), 2 weeks (T2), 3 months (T3) and 6 months (T4) post‐surgery. Student's t‐test (p < .05) was used to compare the EPT values at baseline and T4. anova (p < .05) was used to analyse the EPT variations for all maxillary and mandibular teeth. McNemar test (p < .05) was used to compare the results according to variation in EPT values gathering by variation, no variation and no response.ResultsAt T1, 75 and 65.7% of teeth responded positively whilst 25 and 34.3% did not respond to EPT and TPT, respectively. The variation of the EPT values between T0 and T1 was observed for 50.0% of teeth, whilst no variation was noticed in 25.0% of teeth. At T4, 90.6 and 87.5% of teeth responded positively whilst 9.4 and 12.5% did not respond to EPT and TPT, respectively. At T4, variation of the EPT values between T0 and T4 was observed for 28.1%, whilst no variation was noticed in 62.5% of teeth. There were no statistical differences in EPT results between T0 and T4 (p > .05), but significant differences were observed for EPT values between T1 and T4 (p < .05), and between mandibular and maxillary teeth. The pulp sensibility of maxillary teeth worsened after surgery, before reverting progressively to T0 values, whilst no statistically significant differences were observed for mandibular teeth at the different time points.ConclusionsThese data support the inconsistence of the prophylactic endodontic treatment in healthy vital teeth with apex involvement in large cystic lesions of endodontic origin. Post‐surgery follow‐up with TPT and EPT is recommended to assess pulp status.

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Biphasic pulp blood-flow response to substance P in the dog as measured with a radiolabelled, microsphere injection method

Cited by 27 publications

References 20 publications

Evidence for the Role of Nitric Oxide in the Circulation of the Dental Pulp

Evidence for the Role of Nitric Oxide in the Circulation of the Dental Pulp

Local application of NK1 receptor antagonists and pulpal blood flow in cat

The clinical outcomes of vital intact teeth close to large cystic lesions of endodontic origin: A prospective clinical study

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