Biphasic Magnetic Nanoparticles–Nanovesicle Hybrids for Chemotherapy and Self-Controlled Hyperthermia

Gogoi, Manashjit; Sarma, Haladhar Dev; Bahadur, D.; Banerjee, Rinti

doi:10.2217/nnm.13.90

Cited by 29 publications

(8 citation statements)

References 43 publications

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“…Due to the severe side effects of existing cancer therapies, a lot of novel treatment modalities such as photodynamic therapy [38], photothermal therapy with gold nanoparticles [39,40], hyperthermia with magnetic nanoparticles [11,41] and combination of hyperthermia and chemotherapy [42][43][44][45] have been investigated for treating cancer effectively with an aim to improve the patients' quality of life. In cancer hyperthermia, body temperature of patient is increased partially or wholly to 42-45°C to treat cancer.…”

Section: Cancer Hyperthermiamentioning

confidence: 99%

“…Combined hyperthermia and chemotherapy can be a minimally invasive promising therapeutic modality for treating cancer. A good number of in vitro studies demonstrated the efficacy of combined hyperthermia and chemotherapy than either hyperthermia or chemotherapy alone [43][44][45]. Therapeutic efficacy of docetaxel-loaded magnetic cationic liposome following repeated hyperthermia was investigated in prostate tumour-bearing rats [81].…”

Section: Combined Hyperthermia and Drug Deliverymentioning

confidence: 99%

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Magnetic Nanostructures for Cancer Theranostic Applications

Gogoi

2021

Curr Pathobiol Rep

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Purpose of Review Cancer is a life-threatening disease and one of the leading causes of death globally. Currently a good number therapeutic modalities including chemotherapy are used to treat cancer. All these treatments have their own advantages and disadvantages, and hence, usually two or more therapies are combined for effective treatment of cancer. However, the inadequacy of treatment is so high that in the past few decades, deaths due to cancer did not change much, even after development of several new treatment modalities and drugs. Early detection and treatment are the most important factors for ensuring success of cancer therapies. So, people are continuously working on an endeavour to develop superior technologies for the early detection and treatment of cancer. Nanotechnology is opening up a window of new possibilities or opportunities to address this menace. Magnetic nanostructures (MNSs) can play an important role in cancer theranostic applications. This review highlights the different applications of MNSs in cancer theranostic applications. Recent Findings Magnetic nanoparticles have been extensively investigated for cancer imaging, drug targeting and hyperthermia applications. Summary This paper reviews the different cancer detection and treatment modalities using magnetic nanostructures, their advantages over the traditional methods, current status, challenges and future prospects with the help of illustrative examples from recent literature.

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Section: Cancer Hyperthermiamentioning

confidence: 99%

Section: Combined Hyperthermia and Drug Deliverymentioning

confidence: 99%

Magnetic Nanostructures for Cancer Theranostic Applications

Gogoi

2021

Curr Pathobiol Rep

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“…They are used to target drugs, bioactive substances and genes. These systems selectively deliver therapeutic agents to target tissues, cells and cell compartments to release their cargos [33,34,35]. By doing so, the pharmacological properties, release profile and therapeutic outcomes are improved compared to delivery as free drugs.…”

Section: Polymer Types Used In Preparing Co-delivery Systemsmentioning

confidence: 99%

Polymeric Co-Delivery Systems in Cancer Treatment: An Overview on Component Drugs’ Dosage Ratio Effect

et al. 2019

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Multiple factors are involved in the development of cancers and their effects on survival rate. Many are related to chemo-resistance of tumor cells. Thus, treatment with a single therapeutic agent is often inadequate for successful cancer therapy. Ideally, combination therapy inhibits tumor growth through multiple pathways by enhancing the performance of each individual therapy, often resulting in a synergistic effect. Polymeric nanoparticles prepared from block co-polymers have been a popular platform for co-delivery of combinations of drugs associated with the multiple functional compartments within such nanoparticles. Various polymeric nanoparticles have been applied to achieve enhanced therapeutic efficacy in cancer therapy. However, reported drug ratios used in such systems often vary widely. Thus, the same combination of drugs may result in very different therapeutic outcomes. In this review, we investigated polymeric co-delivery systems used in cancer treatment and the drug combinations used in these systems for synergistic anti-cancer effect. Development of polymeric co-delivery systems for a maximized therapeutic effect requires a deeper understanding of the optimal ratio among therapeutic agents and the natural heterogenicity of tumors.

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“…[3][4][5][6] Among these studies, the combination of chemotherapy with magnetic hyperthermia shows a powerful potency. [7][8][9][10][11][12][13][14][15] Magnetic hyperthermia could treat the localized or deeply existing tumors without side effect by raising the temperature to 43-48 °C.…”

Section: Introductionmentioning

confidence: 99%

Fe3O4/Polycaprolactone Microneedles with Controlled Drug Delivery and Magnetic Hyperthermia

Cheng¹,

Chen²,

Zhu³

2017

Nano Adv

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Biphasic Magnetic Nanoparticles–Nanovesicle Hybrids for Chemotherapy and Self-Controlled Hyperthermia

Abstract: Magnetic nanovesicles containing biphasic suspensions La0.75Sr0.25MnO3 and Fe3O4 nanoparticles encapsulating paclitaxel have potential for combined self-controlled hyperthermia and chemotherapy.

Cited by 29 publications

References 43 publications

Magnetic Nanostructures for Cancer Theranostic Applications

Magnetic Nanostructures for Cancer Theranostic Applications

Polymeric Co-Delivery Systems in Cancer Treatment: An Overview on Component Drugs’ Dosage Ratio Effect

Fe3O4/Polycaprolactone Microneedles with Controlled Drug Delivery and Magnetic Hyperthermia

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