Biphasic indentation of articular cartilage—I. Theoretical analysis

Mak, Arthur F.T.; Lai, W. Michael; Mow, Van C.

doi:10.1016/0021-9290(87)90036-4

Cited by 441 publications

(259 citation statements)

References 46 publications

Supporting

Mentioning

251

Contrasting

Unclassified

Order By: Relevance

“…In this situation, the tissue together with its large water content would behave overall as a near incompressible elastic material. This assumption was consistent with the interpretation of the indentation results using the biphasic poroelastic theories (Oomens et al 1987, Mak et al 1987). According to this theory, the instantaneous response of a soft tissue layer was identical to that of an incompressible elastic solid (ν ≅ 0.5) and the equilibrium properties reflect those of the porous-permeable solid matrix.…”

Section: Discussionsupporting

confidence: 88%

Biomechanical assessment of plantar foot tissue in diabetic patients using an ultrasound indentation system

Zheng

Choi

Wong

et al. 2000

Ultrasound in Medicine & Biology

143

120

View full text Add to dashboard Cite

The biomechanical properties of plantar tissues were investigated for four older neuropathic diabetic patients and four normal younger subjects. Indentation tests were performed at four high pressure areas with three postures in each subject. The tissue thickness and effective Young's modulus were measured by an ultrasound indentation system. The system comprised a pen-size probe having an ultrasound transducer at the tip and a load cell connected in series with it. Results showed that the plantar soft tissues of the elderly diabetic patients were significantly stiffer and thinner when compared with the normal young subjects.For the diabetic subjects tested, the Young's modulus at the 1st metatarsal head was significantly larger than those at the other three sites. This site dependence was not observed in the normal young subjects. The plantar tissue became significantly stiffer in the normal young subjects as a result of posture changes. This posture dependence of the Young's modulus was not established for the elderly diabetic group.

show abstract

Section: Discussionsupporting

confidence: 88%

Biomechanical assessment of plantar foot tissue in diabetic patients using an ultrasound indentation system

Zheng

Choi

Wong

et al. 2000

Ultrasound in Medicine & Biology

143

120

View full text Add to dashboard Cite

show abstract

“…A detailed evaluation of the biological performance of this hydrogel in the repair of articular cartilage defects was described in a previous report (18). have been recently conducted to evaluate the mechanical behavior of articular cartilage (12)(13)(14)(15)19). In the present study we chose to use the model used by Kempson et al (12) and the results obtained showed that the mechanical performance of the repaired surfaces of control and hydrogel graft implants differed from that of hyaline cartilage.…”

Section: Resultsmentioning

confidence: 99%

“…The solid phase is a complex network of collagen with proteoglycan aggregates, forming an incompressible matrix permeable to synovial fluid (11). The indentation test is the most commonly used method for evaluating the mechanical behavior of articular cartilage (12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

Biomechanical and histological evaluation of hydrogel implants in articular cartilage

Malmonge

Zavaglia

Belangero

2000

Braz J Med Biol Res

View full text Add to dashboard Cite

We evaluated the mechanical behavior of the repaired surfaces of defective articular cartilage in the intercondylar region of the rat femur after a hydrogel graft implant. The results were compared to those for the adjacent normal articular cartilage and for control surfaces where the defects remained empty. Hydrogel synthesized by blending poly(2-hydroxyethyl methacrylate) and poly(methyl methacrylate-co-acrylic acid) was implanted in male Wistar rats. The animals were divided into five groups with postoperative follow-up periods of 3, 5, 8, 12 and 16 weeks. Indentation tests were performed on the neoformed surfaces in the knee joint (with or without a hydrogel implant) and on adjacent articular cartilage in order to assess the mechanical properties of the newly formed surface. Kruskal-Wallis analysis indicated that the mechanical behavior of the neoformed surfaces was significantly different from that of normal cartilage. Histological analysis of the repaired defects showed that the hydrogel implant filled the defect with no signs of inflammation as it was well anchored to the surrounding tissues, resulting in a newly formed articular surface. In the case of empty control defects, osseous tissue grew inside the defects and fibrous tissue formed on the articular surface of the defects. The repaired surface of the hydrogel implant was more compliant than normal articular cartilage throughout the 16 weeks following the operation, whereas the fibrous tissue that formed postoperatively over the empty defect was stiffer than normal articular cartilage after 5 weeks. This stiffness started to decrease 16 weeks after the operation, probably due to tissue degeneration. Thus, from the biomechanical and histological point of view, the hydrogel implant improved the articular surface repair. Correspondence

show abstract

“…For data extraction of the biomechanical tests, displacement-time data were numerically fit to the biphasic indentation creep solution to determine the aggregate modulus (Ha) at each test site [8,26]. The dynamic modulus was calculated by determining the stress and strain during the initial ramping portion of the test and identifying the linear slope of the resulting stress or strain curve.…”

Section: Biomechanicsmentioning

confidence: 99%