Biphasic effects of repeated alcohol intake on 24-hour blood pressure in hypertensive patients.

Abe, Hitoshi; Kawano, Yuhei; Kojima, Sunao; Ashida, Takashi; Kuramochi, Morio; Matsuoka, Hiroaki; Omae, Teruo

doi:10.1161/01.cir.89.6.2626

Cited by 100 publications

(74 citation statements)

References 46 publications

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“…Therefore, the authors believe that the rise in cardiac frequency cannot simply be explained by an increase in OSA severity. Alternatively, the relative tachycardia may have been a response to peripheral systemic vasodilation, an acute effect which occurs with alcohol in subjects with intact baroreceptor function [30,31]. This may also have contributed to a rise in the overnight urinary excretion of noradrenalin, as observed in this study.…”

Section: Discussionmentioning

confidence: 63%

Effect of moderate alcohol upon obstructive sleep apnoea

Scanlan

Roebuck²,

Little

et al. 2000

European Respiratory Journal

134

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Moderate-to-large quantities of alcohol are known to aggravate severe obstructive sleep apnoea (OSA), however, the reported effects of moderate alcohol consumption upon mild-to-moderate OSA are inconsistent. Given the reported benefits of moderate alcohol consumption on cardiovascular mortality, recommendations regarding the management of patients with OSA are difficult to formulate. The aim of this study was to evaluate the effects of moderate alcohol on sleep and breathing in subjects with mild-to-moderate OSA.Twenty-one male volunteers, who snored habitually, underwent polysomnography with and without 0.5 g alcohol . kg body weight (BW) -1 consumed 90 min prior to sleep time, in random order. The mean blood alcohol concentration (BAC) following alcohol at the time of lights out was 0.07 g . dL -1 . The distribution amongst the various sleep stages was not significantly altered by alcohol. The mean apnoea/hypopnoea index rose from 7.11.9 to 9.72.1 events . h -1 (meanSEM, p=0.017); however, there was no significant change in the minimum arterial oxygen saturation measured by pulse oximetry Sp,O 2 , apnoea length or snoring intensity. Mean sleep cardiac frequency rose significantly from 53.91.4 to 59.91.9 beats . min -1 (p<0.001) and overnight urinary noradrenalin increased from 14.92.3 to 18.82.3 nmol . mmol creatinine -1 (p=0.061) on the alcohol night compared to the nonalcohol night.To conclude, modest alcohol consumption, giving a mean blood alcohol concentration of 0.07 g . dL

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Section: Discussionmentioning

confidence: 63%

Effect of moderate alcohol upon obstructive sleep apnoea

Scanlan

Roebuck²,

Little

et al. 2000

European Respiratory Journal

134

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“…9,22) In addition, it has been suggested that light to moderate alcohol consumption may reduce anxiety that is considered to be associated with hypertension. 9,23) This study founded that the association between alcohol consumption and the risk of hypertension differed in young and old patients.…”

Section: Discussionmentioning

confidence: 99%

Association between Alcohol Consumption and Hypertension

Son¹

2011

J Korean Soc Hypertens

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“…56 We also examined the effects of repeated alcohol intake in the evening under standardized conditions. 7,57 After 1 week, the BP of hypertensive patients decreased in the evening but increased in the early morning (Figure 1). We further investigated the effects of alcohol restriction for 4 weeks in habitual drinkers with hypertension.…”

Section: Alcohol Intakementioning

confidence: 99%

Diurnal blood pressure variation and related behavioral factors

Kawano

2010

Hypertens Res

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Blood pressure (BP) varies according to many internal and external factors, and behavioral factors have an important role in diurnal BP variation. BP rises sharply on waking in the morning and falls during sleep at night, although it varies throughout the day and night. These changes in BP are closely related to mental and physical activities, and the sympathetic nervous system mainly contributes to the diurnal variation in BP. Other behavioral factors, such as food consumption and obesity, dietary intake of sodium, drinking and smoking habits, consumption of coffee and tea, and bathing, also affect the diurnal variation in BP. Alterations in diurnal BP variation due to behavioral factors are frequently seen in patients with hypertension and can be classified as morning hypertension, daytime hypertension and nighttime hypertension. Appropriate lifestyle modifications may normalize or improve both the level and rhythm of BP in these patients. Hypertension Research (2011) 34, 281-285; doi:10.1038/hr.2010.241; published online 2 December 2010Keywords: ambulatory blood pressure monitoring; diurnal blood pressure variation; lifestyle; mental stress; physical activity INTRODUCTION Blood pressure (BP) varies according to many internal and external factors. There are several distinctive rhythmic variations in BP including diurnal (or circadian) variation, and behavioral factors have an important role in diurnal BP variation. BP rises sharply on waking in the morning and falls during sleep at night, although it varies with changes in mental and physical activities during daytime and nighttime. [1][2][3][4] In addition to the awake and sleep cycle, many behavioral factors, such as mental stress, exercise, food consumption, changes in body weight, dietary intake of sodium and other electrolytes, drinking and smoking habits, consumption of coffee and tea, and bathing, influence both the level and variation in BP. [5][6][7][8] Understanding the influences of those behavioral factors on diurnal BP variation is important for the management of hypertension because alterations in diurnal BP variation due to behavioral factors are observed in many hypertensive subjects. 9,10 It has been shown that ambulatory BP monitoring is useful for assessing the influence of behavioral factors as well as the effects of lifestyle modifications on the level and pattern of BP throughout the day. 11,12 In this review article, I would like to summarize the effects of behavioral factors on diurnal BP variation with respect to the pathophysiology of hypertension and the effects of lifestyle modifications on 24-h BP.

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Biphasic effects of repeated alcohol intake on 24-hour blood pressure in hypertensive patients.

Cited by 100 publications

References 46 publications

Effect of moderate alcohol upon obstructive sleep apnoea

Effect of moderate alcohol upon obstructive sleep apnoea

Association between Alcohol Consumption and Hypertension

Diurnal blood pressure variation and related behavioral factors

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