Biphasic Effects of Geranylgeraniol, Teprenone, and Phytol on the Growth of
            <i>Staphylococcus aureus</i>

Inoué, Yoshihiro; Hada, Toshiko; Shiraishi, Akiko; Hirose, Kazuma; Hamashima, Hajime; Kobayashi, Shigeki

doi:10.1128/aac.49.5.1770-1774.2005

Cited by 135 publications

(78 citation statements)

References 6 publications

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“…Similar result was also observed in the leaves of Lantana camara [13]. Phytol was observed to have antibacterial activities against Staphylococcous aureus by causing damage to cell membranes as a result there is a leakage of potassium ions from bacterial cells [14]. Phytol is a key acyclic diterpene alcohol that is a precursor for vitamins E and K1.…”

Section: Gc-ms Analysissupporting

confidence: 59%

Identification of Phytocompounds in Lawsonia Inermis Using Gc-MS Technique

2017

IJAERD

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Section: Gc-ms Analysissupporting

confidence: 59%

Identification of Phytocompounds in Lawsonia Inermis Using Gc-MS Technique

2017

IJAERD

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“…In addition to that, phytol derivatives have been found to act as immunostimulants by providing long-term memory induction and activating both innate and acquired immunity (Chowdhury & Ghosh 2012). The diterpene phytol has also been reported to possess antimicrobial potentials against Staphylococcus aureus and tuberculosis (Inoue et al 2005;Saikia et al 2010). Chang et al (2007) demonstrated that phytol exhibit neuroprotective effects on human neuroblastoma SH-SY5Y cells when evaluated in vitro by using a simulated ischemia model.…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective effect of the marine macroalgaGelidiella acerosa: identification of active compounds through bioactivity-guided fractionation

Syad

Shafreen

Shunmugaiah

et al. 2016

Pharmaceutical Biology

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Context Gelidiella acerosa (Forsskål) Feldmann & G. Hamel (Rhodophyta-Gelidiales) is a marine red macroalga. Our previous work found that a benzene extract of G. acerosa possesses noticeable neuroprotective activity, when evaluated through in vitro and in vivo systems. Objective Bioactive-guided fractionation and identification of active compounds by column chromatography using solvents of varying polarity. Materials and methods Fractionation was done by column chromatography, antioxidant and anticholinesterase activity was assessed by DPPH and cholinesterase inhibition assays (50-200 mg/ml), compound identification was done by LC-MS analysis, the mode of interaction of active compound was analyzed through docking studies and quantification was done by highperformance thin-layer chromatography (HPTLC) analysis.Results The results suggest that fractions F9-F13 exhibited significant (p50.05) antioxidant and anticholinesterase activities. Hence, these fractions were pooled together and verified for neuroprotective activity. The pooled fraction was subjected to LC-MS analysis and among all the compounds, phytol was previously reported to possess excellent neuroprotective potential. Hence, the neuroprotective potential of phytol was assessed. The results suggest that phytol showed significant (p50.05) antioxidant activities (25-125 mg/ml) with an IC 50 value of 95.27 ± 1.65 mg/ml and cholinesterase inhibitory potential (5-25 mg/ml) with IC 50 values of 2.704 ± 0.07 and 5.798 ± 0.72 mg/ml for AChE and BuChE, respectively. Molecular docking studies suggest that phytol interacts with cholinesterase through the arginine residue of the enzyme. HPTLC quantification showed that about 6.266 mg of phytol was present per mg of pooled fraction. Conclusion The study suggests that phytol might act as the key compound in contributing to the neuroprotective potential of G. acerosa. ARTICLE HISTORY

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“…We have studied the antibacterial activity of terpene alcohols with aliphatic carbon chain against S. aureus in detail [1][2][3] and found that farnesol, which is classified into sesquiterpene alcohol, showed significant antibacterial activity. 1 Moreover, farnesol damages bacterial cell membranes.…”

Section: Introductionmentioning

confidence: 99%

Effect of farnesol on mevalonate pathway of Staphylococcus aureus

et al. 2011

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To investigate the mechanism of action by which farnesol functions as an antibacterial agent and inhibits Staphylococcus aureus growth, the growth rates of S. aureus cultured in farnesol versus S. aureus cultured in farnesol and supplemented with 3-hydroxy-3-methylglutaryl (HMG)-CoA or mevalonate were compared. The investigation was designed to observe whether farnesol affected on the mevalonate pathway by using the intermediate metabolites of the pathway. The resulting growth curves demonstrated that mevalonate reduced the antibacterial activity of farnesol, but HMG-CoA did not inhibit farnesol. These results suggest that farnesol affects the mevalonate pathway. Moreover, farnesol inhibited HMG-CoA reductase activity in an in vitro enzymatic assay.

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Biphasic Effects of Geranylgeraniol, Teprenone, and Phytol on the Growth of Staphylococcus aureus

Cited by 135 publications

References 6 publications

Identification of Phytocompounds in Lawsonia Inermis Using Gc-MS Technique

Identification of Phytocompounds in Lawsonia Inermis Using Gc-MS Technique

Neuroprotective effect of the marine macroalgaGelidiella acerosa: identification of active compounds through bioactivity-guided fractionation

Effect of farnesol on mevalonate pathway of Staphylococcus aureus

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