Biphasic effects of exogenous VEGF on VEGF expression of adult neural progenitors

Vascular endothelial growth factor induces growth of uterine cervix and immune cell recruitment in mice

“…The current observation is similar to findings of an earlier study that showed that low levels of VEGF significantly upregulated the expression of VEGF receptors (Flt1 and KDR), as well as enhanced adult neural progenitor cell differentiation into neurons in the rat. However, unlike our study, high doses downregulated expression of VEGF receptors as well as neurogenesis and they did not examine exogenous VEGF's effect on the levels of endogenous VEGF (Meng et al 2006). Future studies will examine the influence of VEGF on the overall growth of the uterine cervix during pregnancy.…”

Upregulation of Flk-1 by bFGF via the ERK pathway is essential for VEGF-mediated promotion of neural stem cell proliferation

“…It has been reported that VEGF has a biphasic effect on the neural progenitor cells [30]. At low dosages, for instance, 50 ng/ml, VEGF promotes proliferation of neural progenitor cells; at the dosage of 500 ng/ml, however, it enhances neuronal differentiation of adult neural progenitor cells.…”

Neurorestorative treatment of stroke: Cell and pharmacological approaches

“…115 VEGF increases ischemia-induced tyrosine phosphorylation of Kv1.2 potassium channel proteins via activation of the PI3K pathway, enhances proliferation and migration of neural progenitors in the SVZ, and improves striatal neurogenesis, neuronal differentiation, and maturation of neuroblasts in adult rat brains after stroke. 109,116,117 VEGF can be induced in ischemic brain by both cellbased and pharmacological restoration therapies. In most preclinical and clinical studies, however, the introduction of these factors as single agents has resulted in the formation of stabilized blood vessels of only limited duration.…”