Biphasic effects of ethanol on acetylcholine release in the rat prefrontal cortex

Stancampiano, Roberto; Carta, Manolo; Cocco, Stefania; Curreli, Rita; Rossetti, Zvani L.; Fadda, F

doi:10.1016/j.brainres.2003.09.078

Cited by 36 publications

(25 citation statements)

References 25 publications

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“…In our study, we adjusted the analyses for several cardiovascular risk factors and diseases, but we did not have information on all factors. In addition to cardiovascular effects, moderate amounts of alcohol could also act directly by releasing acetylcholine in the hippocampus [44] , thereby affecting cognitive functions. Some studies have proposed that the protective effect of alcohol would be due to the effect of specific antioxidant substances in wine [45] .…”

Section: Discussionmentioning

confidence: 99%

Alcohol Drinking and Cognitive Functions: Findings from the Cardiovascular Risk Factors Aging and Dementia (CAIDE) Study

Ngandu¹,

Helkala²,

Winblad³

et al. 2006

Dement Geriatr Cogn Disord

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Background: Moderate alcohol drinking is suggested to be beneficial for cognitive functions, but the results of previous studies have varied greatly. Little is known about the effects of midlife alcohol drinking on the cognitive functions later in life. Methods: Participants were derived from random, population-based samples studied in Eastern Finland in 1972, 1977, 1982, or 1987. A total of 1,341 participants were reexamined in 1998, after an average follow-up period of 21 years, at ages 65–79 years. Results: The participants who did not drink alcohol at midlife had a poorer performance in episodic memory, psychomotor speed, and executive function in late life as compared with infrequent and frequent drinkers, adjusted for sociodemographic and vascular factors. Also late-life nondrinkers had poorer psychomotor speed and executive function. These findings were evident especially among nonsmokers. Further, no interactions between apolipoprotein E4 and alcohol or sex and alcohol were found. Conclusions: Alcohol drinking both at midlife and later is favorably related to the function in several cognitive domains, including episodic memory, psychomotor speed, and executive function, in late life. However, it is not clear whether the association is causal, what is the possible mechanism, and what would be a safe limit of drinking for the best cognitive function.

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Section: Discussionmentioning

confidence: 99%

Alcohol Drinking and Cognitive Functions: Findings from the Cardiovascular Risk Factors Aging and Dementia (CAIDE) Study

Ngandu¹,

Helkala²,

Winblad³

et al. 2006

Dement Geriatr Cogn Disord

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“…No significant changes in AChE levels were seen at either time in either of the brain regions studied. Many researchers have reported that Alc can decrease ACh release in the animal brain [31,32]. This reduction in ACh release by Alc is likely due to the decrease in ChAT, as shown previously [26,33].…”

Section: Discussionmentioning

confidence: 75%

Effects of Systemic Nicotine, Alcohol or Their Combination on Cholinergic Markers in the Frontal Cortex and Hippocampus of Rat

et al. 2010

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Acute alcohol (Alc) intoxication has been shown to decrease choline acetyltransferase (ChAT) in the rat brain. The present study extends that finding by examining the effects of nicotine (Nic), Alc, and their combination on ChAT and acetylcholinesterase (AChE) in the frontal cortex and hippocampus of rat. The samples were collected at 30 and 120 min after intraperitoneal administration of saline (0.9%, control), Nic (1 mg/kg), Alc (1 g/kg), and Nic + Alc and analyzed by RT-PCR, Western blot and colorimetry. Alc alone considerably reduced ChAT mRNA expression, whereas Nic alone decreased AChE mRNA expression. In contrast, Nic + Alc exposure had resulted in no significant change in the parameters. These findings are consistent with the results of the Western blot and AChE activity analysis. The results, therefore, indicate that Nic and Alc alone may interact with the central cholinergic system. This interactive effect may contribute to a frequent association of tobacco and Alc consumption.

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“…Thus, ethanol could inhibit glutamatergic neurons, reducing acetylcholine concentrations. Recently, an increase of acetylcholine transmission by systemic ethanol acting on cholinergic dendrites and cell bodies (32) showed that the neurochemical consequences of ethanol still warrant additional studies.…”

Section: Discussionmentioning

confidence: 99%

Participation of the cholinergic system in the ethanol-induced suppression of paradoxical sleep in rats

Papale

Andersen

Perry

et al. 2008

Braz J Med Biol Res

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Sleep disturbance is among the many consequences of ethanol abuse in both humans and rodents. Ethanol consumption can reduce REM or paradoxical sleep (PS) in humans and rats, respectively. The first aim of this study was to develop an animal model of ethanol-induced PS suppression. This model administered intragastrically (by gavage) to male Wistar rats (3 months old, 200-250 g) 0.5 to 3.5 g/kg ethanol. The 3.5 g/kg dose of ethanol suppressed the PS stage compared with the vehicle group (distilled water) during the first 2-h interval (0-2 h; 1.3 vs 10.2; P < 0.001). The second aim of this study was to investigate the mechanisms by which ethanol suppresses PS. We examined the effects of cholinergic drug pretreatment. The cholinergic system was chosen because of the involvement of cholinergic neurotransmitters in regulating the sleep-wake cycle. A second set of animals was pretreated with 2.5, 5.0, and 10 mg/kg pilocarpine (cholinergic agonist) or atropine (cholinergic antagonist). These drugs were administered 1 h prior to ethanol (3.5 g/kg) or vehicle. Treatment with atropine prior to vehicle or ethanol produced a statistically significant decrease in PS, whereas pilocarpine had no effect on minutes of PS. Although the mechanism by which ethanol induces PS suppression is not fully understood, these data suggest that the cholinergic system is not the only system involved in this interaction.

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Biphasic effects of ethanol on acetylcholine release in the rat prefrontal cortex

Cited by 36 publications

References 25 publications

Alcohol Drinking and Cognitive Functions: Findings from the Cardiovascular Risk Factors Aging and Dementia (CAIDE) Study

Alcohol Drinking and Cognitive Functions: Findings from the Cardiovascular Risk Factors Aging and Dementia (CAIDE) Study

Effects of Systemic Nicotine, Alcohol or Their Combination on Cholinergic Markers in the Frontal Cortex and Hippocampus of Rat

Participation of the cholinergic system in the ethanol-induced suppression of paradoxical sleep in rats

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