Biphasic Effect of 1,25-Dihydroxyvitamin D3 on Human Hair Follicle Growth and Hair Fiber Production in Whole-Organ Cultures

Harmon, Charles S.; Nevins, Thomas D.

doi:10.1111/1523-1747.ep12394788

Cited by 58 publications

(51 citation statements)

References 26 publications

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“…IL-1 has been shown to inhibit hair growth in vitro and may be one of the factors triggering the arrest of hair growth in vivo. 16 TNF-a also inhibits hair follicle growth in vitro. 17 The IL-1 and TNF-a gene polymorphisms have been previously investigated.…”

Section: Discussionmentioning

confidence: 99%

Promoter region polymorphism of macrophage migration inhibitory factor is strong risk factor for young onset of extensive alopecia areata

et al. 2005

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We have demonstrated that serum macrophage migration inhibitory factor (MIF) was significantly elevated in patients with extensive alopecia areata (AA). Recently, functional polymorphisms have been identified in the MIF promoter region. To address the functional and prognostic relevance of the À173G/C and À794[CATT] 5-8 repeat polymorphisms in MIF genes in patients with extensive AA, 113 patients with extensive AA and 194 healthy controls were genotyped. We found that MIFÀ173*C was a risk factor for early onset (o20 years) of extensive AA (odds ratio for GC heterozygotes with À173G/C was 4.88 (95% CI, 2.04-11.8), P ¼ 0.00038; odds ratio for CC homozygotes with À173G/C was 10.42 (95% CI, 2.56-43.5), P ¼ 0.0011). We found no statistically significant differences in the genotype frequencies of the À794[CATT] 5-8 repeat polymorphism and extensive AA. These results suggest that polymorphisms within the MIFÀ173*C allele confer an increased risk of susceptibility to the extensive forms of AA, especially with an early onset of disease. MIF is therefore suggested to be closely implicated in the pathogenesis of the more extensive forms of AA.

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Section: Discussionmentioning

confidence: 99%

Promoter region polymorphism of macrophage migration inhibitory factor is strong risk factor for young onset of extensive alopecia areata

et al. 2005

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“…HH/GLI-EGFR signaling in the ORS may also protect anagen hair follicles from IL-1-induced inhibition of growth and hair loss (29,30,73) by upregulating the expression of the IL-1-antagonist IL1R2. Another consequence of combined GLI/EGFR signaling may be the activation of Notch signaling by the Notch ligand JAG2.…”

Section: Discussionmentioning

confidence: 99%

Selective Modulation of Hedgehog/GLI Target Gene Expression by Epidermal Growth Factor Signaling in Human Keratinocytes

Kasper

Schnidar

Neill

et al. 2006

Molecular and Cellular Biology

210

228

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Hedgehog (HH)/GLI signaling plays a critical role in epidermal development and basal cell carcinoma. Here, we provide evidence that epidermal growth factor receptor (EGFR) signaling modulates the target gene expression profile of GLI transcription factors in epidermal cells. Using expression profiling and quantitative reverse transcriptase PCR, we identified a set of 19 genes whose transcription is synergistically induced by GLI1 and parallel EGF treatment. Promoter studies of a subset of GLI/EGF-regulated genes, including the genes encoding interleukin-1 antagonist IL1R2, Jagged 2, cyclin D1, S100A7, and S100A9, suggest convergence of EGFR and HH/GLI signaling at the level of promoters of selected direct GLI target genes. Inhibition of EGFR and MEK/ERK but not of phosphatidylinositol 3-kinase/AKT abrogated synergistic activation of GLI/EGF target genes, showing that EGFR can signal via RAF/MEK/ ERK to cooperate with GLI proteins in selective target gene regulation. Coexpression of the GLI/EGF target IL1R2, EGFR, and activated ERK1/2 in human anagen hair follicles argues for a cooperative role of EGFR and HH/GLI signaling in specifying the fate of outer root sheath (ORS) cells. We also show that EGF treatment neutralizes GLI-mediated induction of epidermal stem cell marker expression and provide evidence that EGFR signaling is essential for GLI-induced cell cycle progression in epidermal cells. The results suggest that EGFR signaling modulates GLI target gene profiles which may play an important regulatory role in ORS specification, hair growth, and possibly cancer.

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“…This process that occurs at least in one-third of AGA cases [10,[26][27][28][29] initiates at infundibulum mediated by bacteria, UV irradiation, chemical and/or mechanical stress. Keratinocytes rapidly respond to stressors releasing interleukin-1α (IL-1α) [30,31] that was shown to inhibit hair growth in vitro [32][33][34]. A transcriptional cascade is activated, increasing pro-inflammatory cytokines (IL-1α, IL-1β, TNFα), chemokines (IL-8, MCPs), collagenases and others.…”

Section: Pathophysiology Of Agmentioning

confidence: 99%

Androgenic alopecia and dutasteride in hair mesotherapy: A short review

Busanello¹,

Turcatel²

2018

Our Dermatol Online

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Biphasic Effect of 1,25-Dihydroxyvitamin D3 on Human Hair Follicle Growth and Hair Fiber Production in Whole-Organ Cultures

Cited by 58 publications

References 26 publications

Promoter region polymorphism of macrophage migration inhibitory factor is strong risk factor for young onset of extensive alopecia areata

Promoter region polymorphism of macrophage migration inhibitory factor is strong risk factor for young onset of extensive alopecia areata

Selective Modulation of Hedgehog/GLI Target Gene Expression by Epidermal Growth Factor Signaling in Human Keratinocytes

Androgenic alopecia and dutasteride in hair mesotherapy: A short review

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