Biphasic dopamine regulation in mesoaccumbens pathway in response to non-contingent binge and escalating methamphetamine regimens in the Wistar rat

Keller, Courtney M.; Salvatore, Michael F.; Pruett, Brandon S.; Guerin, Glenn F.; Goeders, Nicholas E.

doi:10.1007/s00213-011-2301-9

Cited by 26 publications

(51 citation statements)

References 68 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…19 DAT expression is much less in SN and VTA compared with striatum and nucleus accumbens in rodent, 19 and the present results provide additional evidence that DA regulation is less influenced by DAT in the somatodendritic compartments. The loss of DAT was associated with decreased DA tissue content and TH protein, but only in the terminal fields of striatum and nucleus accumbens.…”

Section: Discussionsupporting

confidence: 51%

“…Dopamine release in the substantia nigra has been established for 40 years, 38,39 and this study further supports that TH function may be a primary component of how much DA is available for release, particularly since evidence also shows that DA D 2 agonists are much less effective in inhibiting DA release therein 40 and shows less efficiency of DA uptake in the midbrain 1–3,41 and less DA release in the midbrain. 2–4,42 The expression of DAT protein relative to TH protein is nearly 10–20-fold less in the somatodendritic compartments versus the terminal fields, 19 and DA tissue content is more dependent upon TH function in the somatodendritic regions. 5 Our results seem to further extend the critical differences in DA regulation between the two compartments, which may come into play to determine how DAT affects TH activity in DA-dependent behavioral outcomes, 43–47 particularly if considering the influence of DA neurotransmission in the somatodendritic compartments upon behavior 25–28,48–50 and in disease states affected by DA loss like Parkinson’s disease.…”

Section: Discussionmentioning

confidence: 99%

“…From the perspective of reward, recent work indicates that amphetamine self-administration was more associated with expression of DA D 2 /D 3 receptors in the VTA rather than the nucleus accumbens. 53 Methamphetamine, which acts in part via DAT, also produces a differential impact on DA regulation in the VTA versus NAc 19 and upon TH phosphorylation. 54 …”

Section: Discussionmentioning

confidence: 99%

“…17 In the rodent, the relative expression of DAT versus TH protein is much greater in the terminal fields versus the somatodendritic compartments in the nigrostriatal and mesoaccumbens pathways. 19 Therefore, it would stand to reason that the loss of DAT may impact TH regulation to a greater extent in the terminal fields, given the evidence that DAT function influences DA homeostasis 20–22 and DA-related behavior. 23,24 However, DA function in the somatodendritic compartments can affect behavioral outcomes.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Regulation of Tyrosine Hydroxylase Expression and Phosphorylation in Dopamine Transporter-Deficient Mice

Salvatore

Calipari

Jones

2016

ACS Chem. Neurosci.

Self Cite

View full text Add to dashboard Cite

Tyrosine hydroxylase (TH) and dopamine transporters (DATs) regulate dopamine (DA) neurotransmission at the biosynthesis and reuptake steps, respectively. Dysfunction or loss of these proteins occurs in impaired locomotor or addictive behavior, but little is known about the influence of DAT expression on TH function. Differences in TH phosphorylation, DA tissue content, L-DOPA biosynthesis, and DA turnover exist between the somatodendritic and terminal field compartments of nigrostriatal and mesoaccumbens pathways. We examined whether differential DAT expression affects these compartmental differences in DA regulation by comparing TH expression and phosphorylation at ser31 and ser40. In heterozygous DAT knockout (KO) (+/−) mice, DA tissue content and DA turnover were unchanged relative to wild-type mice, despite a 40% reduction in DAT protein expression. In DAT KO (−/−) mice, DA turnover increased in all DA compartments, but DA tissue content decreased (90–96%) only in terminal fields. TH protein expression and phosphorylation were differentially affected within DA pathway compartments by relative expression of DAT. TH protein decreased (~74%), though to a significantly lesser extent than DA, in striatum and nucleus accumbens (NAc) in DAT −/− mice, with no decrease in substantia nigra or ventral tegmental area. Striatal ser31 TH phosphorylation and recovery of DA relative to TH protein expression in DAT +/− and DAT −/− mice decreased, whereas ser40 TH phosphorylation increased ~2- to 3-fold in striatum and NAc of DAT −/− mice. These results suggest that DAT expression affects TH expression and phosphorylation largely in DA terminal field compartments, further corroborating evidence for dichotomous regulation of TH between somatodendritic and terminal field compartments of the nigrostriatal and mesoaccumbens pathways.

show abstract

Section: Discussionsupporting

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Regulation of Tyrosine Hydroxylase Expression and Phosphorylation in Dopamine Transporter-Deficient Mice

Salvatore

Calipari

Jones

2016

ACS Chem. Neurosci.

Self Cite

View full text Add to dashboard Cite

show abstract

“…On PND 21 weaned male rat pups were divided into SIR and group-reared rats. Rats were injected twice daily and subcutaneously with either saline or an escalating dose of MA, starting with 0.2 mg/kg on PND 35 and ending with 6 mg/kg on PND 50 (table 1) [27,28,29]. Dosing with MA or saline took place at 9.00 and 15.00 h every day for 16 consecutive days.…”

Section: Methodsmentioning

confidence: 99%

Late-Life Effects of Chronic Methamphetamine Exposure during Puberty on Behaviour and Corticostriatal Mono-Amines in Social Isolation-Reared Rats

Strauss¹,

Brink²,

Möller³

et al. 2014

Dev Neurosci

View full text Add to dashboard Cite

Chronic methamphetamine (MA) abuse results in an acute psychosis indistinguishable from paranoid schizophrenia. However, less is known of the interaction between MA use and environmental insults, and how this contributes to late-onset psychopathology. Using social isolation rearing (SIR), a neurodevelopmental animal model of schizophrenia, we investigated the association between changes in corticostriatal mono-amines and putative behaviours related to MA-induced psychosis in isolation and group-housed rats following chronic MA or saline exposure. Weaned male offspring of MA-naive female Wistar rats, either group- or isolation-housed from postnatal day (PND) +21, received saline (2 ml/kg s.c. b.i.d.) or an escalating dose of MA (0.2-6 mg/kg s.c. b.i.d.) for 16 days from PND +35 to +50. On PND +78, offspring were tested for deficits in social interactive behaviour (SIB) and prepulse inhibition (PPI) of startle, with frontal cortex and striatum harvested for the assessment of mono-amine concentrations. SIR significantly reduced rearing time, staying together, approaching and anogenital sniffing (outward-directed SIB), but increased self-grooming and locomotor activity (self-directed SIB), and also induced profound deficits in PPI. Pubertal MA exposure in group-housed animals also induced similar alterations in outward- and self-directed SIB and reduced PPI. Combined MA + SIR exposure evoked a similarly intense behavioural response as SIR or MA separately, with no exacerbation evident. Neither treatment separately nor together affected corticostriatal serotonin or noradrenaline levels, although frontal cortical dopamine (DA) levels were significantly increased in SIR and MA + group-housed animals. A trend towards further elevated frontal cortical DA was noted in the MA + SIR treatment group. Striatal DA was unaltered by all treatments. This study provides the first evidence that chronic pubertal MA exposure evokes postpubertal psychosis-like behaviours in rats of similar intensity to that induced by a neurodevelopmental animal model of schizophrenia (SIR). Moreover, the study is unique in that these behavioural changes occur together with associated changes in frontal cortical but not striatal DA, without affecting other mono-amines, and strongly implicates frontal cortical DA changes in the psychotogenic effects of early-life MA exposure or environmental insult. Although MA exposure in animals with a history of environmental insult (i.e. MA + SIR) has similar effects, combined exposure was not additive with regard to behavioural or neurochemical changes. We conclude that a ceiling effect or compensatory mechanisms prevent more pronounced neurobehavioural deficits occurring following MA + SIR treatment, at least under the current study conditions.

show abstract

Escalating Methamphetamine Regimen Induces Compensatory Mechanisms, Mitochondrial Biogenesis, and GDNF Expression, in Substantia Nigra

Valian

Ahmadiani

Dargahi

2017

J of Cellular Biochemistry

View full text Add to dashboard Cite

Methamphetamine (MA) produces long-lasting deficits in dopaminergic neurons in the long-term use via several neurotoxic mechanisms. The effects of MA on mitochondrial biogenesis is less studied currently. So, we evaluated the effects of repeated escalating MA regimen on transcriptional factors involved in mitochondrial biogenesis and glial-derived neurotrophic factor (GDNF) expression in substantia nigra (SN) and striatum of rat. In male Wistar rats, increasing doses of MA (1-14 mg/kg) were administrated twice a day for 14 days. At the 1st, 14th, 28th, and 60th days after MA discontinuation, we measured the PGC1α, TFAM and NRF1 mRNA levels, indicator of mitochondrial biogenesis, and GDNF expression in SN and striatum. Furthermore, we evaluated the glial fibrillary acidic protein (GFAP) and Iba1 mRNA levels, and the levels of tyrosine hydroxylase (TH) and α-synuclein (α-syn) using immunohistochemistry and real-time polymerase chain reaction (PCR). We detected increments in PGC1α and TFAM mRNA levels in SN, but not striatum, and elevations in GDNF levels in SN immediately after MA discontinuation. We also observed increases in GFAP and Iba1 mRNA levels in SN on day 1 and increases in Iba1 mRNA on days 1 and 14 in striatum. Data analysis revealed that the number of TH cells in the SN did not reduce in any time points, though TH mRNA levels was increased on day 1 after MA discontinuation in SN. These data show that repeated escalating MA induces several compensatory mechanisms, such as mitochondrial biogenesis and elevation in GDNF in SN. These mechanisms can reverse MA-induced neuroinflammation and prevent TH-immunoreactivity reduction in nigrostriatal pathway. J. Cell. Biochem. 118: 1369-1378, 2017. © 2016 Wiley Periodicals, Inc.

show abstract

Biphasic dopamine regulation in mesoaccumbens pathway in response to non-contingent binge and escalating methamphetamine regimens in the Wistar rat

Cited by 26 publications

References 68 publications

Regulation of Tyrosine Hydroxylase Expression and Phosphorylation in Dopamine Transporter-Deficient Mice

Regulation of Tyrosine Hydroxylase Expression and Phosphorylation in Dopamine Transporter-Deficient Mice

Late-Life Effects of Chronic Methamphetamine Exposure during Puberty on Behaviour and Corticostriatal Mono-Amines in Social Isolation-Reared Rats

Escalating Methamphetamine Regimen Induces Compensatory Mechanisms, Mitochondrial Biogenesis, and GDNF Expression, in Substantia Nigra

Contact Info

Product

Resources

About