Biphasic development of muscle fibers in the fetal lamb

Ashmore, C. R.; Robinson, D.; Rattray, P. V.; Doerr, L.

doi:10.1016/0014-4886(72)90071-4

Cited by 110 publications

(47 citation statements)

References 17 publications

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“…In the bovine, the presence of the IGFII mRNA and both the IGFs receptors coincides with muscle differentiation [35]. This coincidence is found in other species such as in the ovine [2,34], in the porcine [3,25], and in the murine species [4,38]. Thus, in muscle cells, in vivo, IGF-11 might act as an autocrine pathway on muscle cell differentiation, as has been shown in vitro by Florini et al.…”

supporting

confidence: 55%

Characterisation and location of insulin-like-growth factor (IGF) receptors in the foetal bovine Semitendinosus muscle

Listrat¹,

Jammes²,

Djianne³

et al. 1999

Reprod. Nutr. Dev.

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supporting

confidence: 55%

Characterisation and location of insulin-like-growth factor (IGF) receptors in the foetal bovine Semitendinosus muscle

Listrat¹,

Jammes²,

Djianne³

et al. 1999

Reprod. Nutr. Dev.

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“…Myotube development in the innervated soleus muscle (Ontell et al, 1988a1, as in other mammalian muscles (Ishikawa, 1966;Kelly and Zacks, 1969;Ashmore et al, 1972;Ontell and Kozeka, 1984a), is a biphasic phenomenon, involving discrete myogenic waves separated by a temporal delay of -2 days. At 14 days in utero (the time of laser ablation of the spinal cord in this study), the soleus muscle is a discrete muscle consisting of primary myotubes and mononucleated cells.…”

Section: Aneural Muscle Developmentmentioning

confidence: 99%

“…Vertebrate muscle development is a biphasic phenomenon, characterized by successive myogenic waves, resulting in two discrete populations of myotubes, referred to as primary (i.e., first-formed) and secondary myotubes (Ishikawa, 1966;Kelly and Zacks, 1969;Ashmore et al, 1972;Ontell and Kozeka, 1984a;Ontell et al, 1988a). In avian muscle, where access to the fetus in ovo permits experimental manipulations, it has been suggested that the formation of primary myotubes is nerve-independent, while the formation of secondary myotubes is nervedependent (Butler et al, 1982;McLennan, 1983;Phillips and Bennett, 1984;Crow and Stockdale, 1986; however, see Fredette and Landmesser, 1991).…”

Section: Introductionmentioning

confidence: 99%

Ablation of the fetal mouse spinal cord: The effect on soleus muscle cytoarchitecture

Hughes

Schade

Ontell

1992

Developmental Dynamics

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A technique is described whereby it is possible to surgically ablate the lumbosacral spinal cord of a developing mouse fetus without interfering with fetal viability. The lumbosacral spinal cords of 14-day in utero, 129ReJ mice were ablated with a Cooper Nd-YAG laser, and the fetuses, enclosed in their membranes and attached to the uterus by their placentae, were allowed to develop in the abdominal cavity of the dam. The cytoarchitecture and the temporal pattern of organogenesis of aneural soleus muscles were studied in spaced, serial, transverse, ultrathin sections of muscles of 16-and 18-day gestation and newborn (20-day gestation) mice. At the time of surgery, the soleus muscle was a discrete mass consisting of primary myotubes and a pleomorphic population of mononucleated cells. Axon bundles and blood vessels were found at the muscle's periphery, but had not penetrated throughout the muscle mass. The organogenesis of the aneural muscle was remarkably similar to that of the innervated soleus muscle (Ontell et al., Am J Anat 181: [267][268][269][270][271][272][273][274][275][276][277][278]1988). In the aneural muscle, as in the innervated muscle, significant numbers of secondary myotubes formed all along the lengths of primary myotubes. Moreover, the time course of myotube formation, the dynamics of cluster formation and cluster dispersal, and the ultrastructural appearance of the myotubes mimicked that observed in innervated muscle. The frequency of necrotic myotubes was no greater in the aneural muscle than in the innervated soleus muscle. Myotube maturation was similar in aneural and innervated soleus muscles until 18 days gestation. However, at birth, aneural myotubes appeared to be slightly less mature than innervated myotubes. Thus, the major morphogenic phenomena that characterize the development of the soleus muscle appear to be independent of innervation.

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“…Several electron microscopic studies (e.g., lamb, Ashmore et al, 1972;pig, Ashmore et al, 1973) have described, in single section analyses, the general cellular characteristics of the developmental processes. Formation of primary and secondary myotubes appears to occur broadly as in small animals, although there has been no demonstration that primary myotubes necessarily form a continuous, full-length framework for the muscle.…”

Section: Introductionmentioning

confidence: 99%

Formation of new myotubes occurs exclusively at the multiple innervation zones of an embryonic large muscle

Duxson

Sheard

1995

Developmental Dynamics

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This work examines the general principle of whether production of embryonic muscle fibres is invariably linked to sites of innervation, as we have previously reported in small rodent muscles (Duxson et al. 119891 Development 1OE74.3-750). The experimental strategy has been to make a detailed electron microscopic analysis of the formation of new myotubes in a large muscle having multiple, discrete innervation zones. The particular model system is the guinea pig sternomastoid muscle, a strap-like, parallel-fibred muscle with four distinct endplate bands, both in the embryo and the adult. Primary myotubes in the developing muscle extended from tendon to tendon of the muscle and were innervated at each of the multiple endplate zones. Each point of innervation of the primary myotubes was a focus around which many new secondary myotubes formed, and each secondary myotube was approximately centred on one of the innervation sites of its supporting primary myotube. This confirms our previous report, in rat IVth lumbrical muscle, of an invariable association between sites of formation of new secondary myotubes and sites of innervation. We suggest that, in vivo, nerve terminals either directly induce the initial myoblast fusions which give rise to new secondary myotubes, or induce some precondition for fusion. An alternative hypothesis is that a common patterning influence in the muscle localizes both innervation and secondary myotube formation to the same zone. The pattern of secondary myotube production in the embryo has important implications for the size and final architecture of muscles in larger animals, and some of these are discussed. o 1995 Wiley-Liss, Inc.

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Biphasic development of muscle fibers in the fetal lamb

Cited by 110 publications

References 17 publications

Characterisation and location of insulin-like-growth factor (IGF) receptors in the foetal bovine Semitendinosus muscle

Characterisation and location of insulin-like-growth factor (IGF) receptors in the foetal bovine Semitendinosus muscle

Ablation of the fetal mouse spinal cord: The effect on soleus muscle cytoarchitecture

Formation of new myotubes occurs exclusively at the multiple innervation zones of an embryonic large muscle

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