Biphasic calcium phosphate coated with poly-d,l-lactide-co-glycolide biomaterial as a bone substitute

Biocomposites and hybrid biomaterials based on calcium orthophosphates

“…490 Another research group created porous PDLLA/BCP scaffolds and coated them with a hydrophilic PEG/vancomycin composite for both drug delivery purposes and surface modification. 491 More relevantly, both PLGA/BCP 492,493 and PLLA/ BCP 494 biocomposites were fabricated, and their cytotoxicity and fibroblast properties were found to be acceptable for natural bone tissue reparation, filling and augmentation. 495,496 PCL/BCP 497 and gelatin/BCP 498,499 biocomposites are known as well.…”

Calcium orthophosphate-based biocomposites and hybrid biomaterials

“…Another research group created porous PDLLA/BCP scaffolds and coated them with a hydrophilic PEG/vancomycin composite for both drug-delivery purposes and surface modification [406]. More to the point, PLGA/BCP composites were fabricated [407,408] and their cytotoxicity and fibroblast properties were found to be acceptable for natural bone tissue reparation, filling, and augmentation [409,410]. PCL/BCP biocomposites are known as well [411].…”

Multifunctional and hybrid systems based on calcium-phosphate and hydroxyapatite for preventive and regenerative medicine

“…Korišćenje kompozitnog biomaterijala, BCP/PLGA u formi granula u lečenju defekata alveolarne kosti je takođe ukazalo na njegov potencijal koštane regeneracije. In vitro istraži-vanja na ćelijama miševa takođe su potvrdila uspešnu adheziju ćelija fibroblasta na površini ovog materijala [70]. Jedno od značajnih svojstava BCP je njegova hemijska sličnost sa neorganskom komponentom humane kosti, dok PLGA karakteriše visok stepen biokompatibilnosti i netoksičnosti [71].…”