Biphasic alveolosquamoid renal carcinoma: a histomorphological, immunohistochemical, molecular genetic, and ultrastructural study of a distinctive morphologic variant of renal cell carcinoma

Petersson, Fredrik; Bulimbašić, Stela; Hes, Ondřej; Slávik, Pavol; Martínek, Petr; Michal, Michal; Gomolčáková, Barbora; Hora, Milan; Damjanov, Ivan

doi:10.1016/j.anndiagpath.2012.08.007

Cited by 38 publications

(40 citation statements)

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“…are identical to the ‘glomeruloid’ morphology illustrated in the subsequent publications by Mantoan Padilha et al . and Tickoo et al ., the ‘alveolo‐squamoid’ morphology reported by Petersson et al ., and the ‘squamoid‐alveolar’ formations in the study by Hes et al . Focal ‘glomeruloid formations’ were also noted in four of 10 solid‐papillary RCCs in the study by Ulamec et al …”

Section: Discussionmentioning

confidence: 74%

“…Follow-up was available for 23 patients (median 24 months, range 1-244 months): 19 were alive without disease, one was Introduction Biphasic squamoid alveolar renal cell carcinoma (RCC) was recently proposed as a distinctive subtype of papillary RCC by Hes et al 1 Their study included 21 cases with detailed clinicopathological, immunohistochemical and molecular evaluation, and represented a follow-up of their initial study of two RCCs with this type of morphology. 2 The key feature of this entity is the biphasic morphology showing a dual cell population-larger eosinophilic cells with abundant cytoplasm and higher-grade nuclei, usually clustered in aggregates or nests resembling alveolar structures, and a smaller cell population of cuboidal and amphophilic cells with scanty cytoplasm that surround and are admixed with the larger cells. Emperipolesis, composed of neutrophils and cell fragments and debris, was observed in the larger cells in all cases.…”

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confidence: 99%

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Biphasic papillary renal cell carcinoma is a rare morphological variant with frequent multifocality: a study of 28 cases

et al. 2018

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Aims To further characterise biphasic squamoid renal cell carcinoma (RCC), a recently proposed variant of papillary RCC. Methods and results We identified 28 tumours from multiple institutions. They typically showed two cell populations—larger cells with eosinophilic cytoplasm and higher‐grade nuclei, surrounded by smaller, amphophilic cells with scanty cytoplasm. The dual morphology was variable (median 72.5% of tumour, range 5–100%); emperipolesis was found in all cases. The male/female ratio was 2:1, and the median age was 55 years (range 39–86 years). The median tumour size was 20 mm (range 9–65 mm). Pathological stage pT1a was found in 21 cases, pT1b in three, and pT3a and pT3b in one each (two not available). Multifocality was found in 32%: multifocal biphasic RCC in one case, biphasic + papillary RCC in two cases, biphasic + clear cell RCC in three cases, biphasic + low‐grade urothelial carcinoma of the renal pelvis in one case, and biphasic + Birt–Hogg–Dubé syndrome in one case. Positive immunostains included: PAX8, cytokeratin (CK) 7, α‐methylacyl‐CoA racemase, epithelial membrane antigen, and vimentin. Cyclin D1 was expressed only in the larger cells. The Ki67 index was higher in the larger cells (median 5% versus ≤1%). Negative stains included: carbonic anhydrase 9, CD117, GATA‐3, WT1, CK5/6, and CK20; CD10 and 34βE12 were variably expressed. Gains of chromosomes 7 and 17 were found in two evaluated cases. Follow‐up was available for 23 patients (median 24 months, range 1–244 months): 19 were alive without disease, one was alive with recurrence, and one had died of disease (two had died of other causes). Conclusions Biphasic papillary RCC is a rare variant of papillary RCC, and is often multifocal.

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Section: Discussionmentioning

confidence: 74%

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confidence: 99%

Biphasic papillary renal cell carcinoma is a rare morphological variant with frequent multifocality: a study of 28 cases

et al. 2018

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“…Two cases designated as ‘biphasic alveolo‐squamoid renal carcinoma’ were initially reported in 2012 by Petersson et al . One of these two cases was later included in a larger series of 21 cases put together by Hes et al .…”

Section: Biphasic Squamoid Papillary Rccmentioning

confidence: 99%

“…Additionally, a substantial proportion of biphasic squamoid papillary RCCs show at least focal papillary morphology, as seen in papillary RCC, type 1. To date, ~100 cases of biphasic squamoid papillary RCC have been reported in the English‐language literature, including two examples arising in renal allografts …”

Section: Biphasic Squamoid Papillary Rccmentioning

confidence: 99%

New and emerging renal entities: a perspective post‐WHO 2016 classification

2018

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Renal tumours include a heterogeneous and diverse spectrum of neoplasms. Recent advances in this field have significantly improved our understanding of the morphological, immunohistochemical, molecular, epidemiological and clinical characteristics of renal tumours, which led to the new Vancouver classification of renal neoplasia and the new World Health Organization (WHO) classification of renal cell tumours. This review aims to summarise the new information and evidence on several new and emerging/provisional renal entities, which were mostly generated after the recent classification of renal neoplasia. We include in this review the following new and emerging/provisional renal entities: succinate dehydrogenase‐deficient renal cell carcinoma, thyroid‐like follicular carcinoma of the kidney, anaplastic lymphoma kinase rearrangement‐associated renal cell carcinoma, renal cell carcinomas with prominent smooth muscle stroma, fumarate hydratase‐deficient renal cell carcinoma, biphasic squamoid papillary renal cell carcinoma, eosinophilic solid and cystic renal cell carcinoma, atrophic kidney‐like renal cell carcinoma, clear cell renal cell carcinoma with giant cells and emperipolesis, Warthin‐like papillary renal cell carcinoma, and low‐grade oncocytic renal tumour (CD117‐negative; cytokeratin 7‐positive). Some of these entities, such as succinate dehydrogenase‐deficient renal cell carcinoma, have already been recognised as new entities in the WHO classification, and some have been recognised as provisional/emerging entities. However, we include in this review several additional entities that, on the basis of the published evidence, also warrant this designation. We hope that this review will ease the navigation through this complex and evolving field, and will inform and stimulate new studies and discussions.

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“…Biphasic squamoid alveolar renal cell carcinoma (BSARCC) is a rare cancer subtype, representing 0.1% of total papillary renal cell carcinoma (PRCC) cases . These BSARCC tumors, first described in 2012 by Ptersson et al ., are characterized by their biphasic squamoid differentiation. More recent studies have explored the immune phenotypes, molecular genetics, and clinicopathologic characteristics of these tumors .…”

Section: Introductionmentioning

confidence: 99%

Biphasic squamoid alveolar renal carcinoma with positive CD57 expression: A clinicopathologic study of three cases

Zhou

et al. 2019

Pathology International

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Biphasic squamoid alveolar renal cell carcinoma (BSARCC) is a rare and recently characterized form of papillary renal cell carcinoma (PRCC). Herein, we describe three cases of BSARCC that were CD57+. Among a total of 90 cases of PRCC, three cases were found to be consistent with a diagnosis of BSARCC. In addition to reviewing these cases, we reviewed the relevant literature pertaining to this form of cancer and assessed the immunohistochemical staining for CD57 on the available tumor samples. The three BSARCC cases in the present study were composed of two primary populations of cells. Tumors stained positive for CK, PAX8, CK7, CK19, AMACR, EMA, and vimentin. Larger cells expressed detectable levels of cyclin D1, and expression of CD57 was limited to the larger cells. All three patients were alive and free of disease during the most recent follow‐up. Our results suggest that the CD57 positivity of at least a subset of cases should necessitate their differentiation from cases of metanephric adenoma.

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Biphasic alveolosquamoid renal carcinoma: a histomorphological, immunohistochemical, molecular genetic, and ultrastructural study of a distinctive morphologic variant of renal cell carcinoma

Cited by 38 publications

References 19 publications

Biphasic papillary renal cell carcinoma is a rare morphological variant with frequent multifocality: a study of 28 cases

Biphasic papillary renal cell carcinoma is a rare morphological variant with frequent multifocality: a study of 28 cases

New and emerging renal entities: a perspective post‐WHO 2016 classification

Biphasic squamoid alveolar renal carcinoma with positive CD57 expression: A clinicopathologic study of three cases

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