Biphasic alterations in coronary smooth muscle Ca2+ regulation in a repeat cross-sectional study of coronary artery disease severity in metabolic syndrome

McKenney‐Drake, Mikaela L.; Rodenbeck, Stacey D.; Owen, Meredith K.; Schultz, Kyle A.; Alloosh, Mouhamad; Tune, Johnathan D.; Sturek, Michael

doi:10.1016/j.atherosclerosis.2016.03.032

Cited by 14 publications

(22 citation statements)

References 34 publications

(47 reference statements)

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“…A relevant lesson from preclinical studies is that intracellular calcium stores during the progression of coronary atherosclerosis increase in early disease and decrease in late disease compared to healthy controls [ 48 ]. This biphasic relationship is illustrated in the green curve in Figure 3 .…”

Section: Discussionmentioning

confidence: 99%

Atherosclerosis Imaging with 18F-Sodium Fluoride PET

et al. 2020

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The evidence on atherosclerosis imaging with 18F-sodium-fluoride (NaF) positron emission tomography (PET) is hotly debated because of the different patient characteristics, methodology, vascular beds, etc. in reported studies. This review is a continuation of a previous review on this topic, which covered the period 2010–2018. The purpose was to examine whether some of the most important questions that the previous review had left open had been elucidated by the most recent literature. Using principles of a systematic review, we ended analyzing 25 articles dealing with the carotids, coronary arteries, aorta, femoral, intracranial, renal, and penile arteries. The knowledge thus far can be summarized as follows: by targeting active arterial microcalcification, NaF uptake is considered a marker of early stage atherosclerosis, is age-dependent, and consistently associated with cardiovascular risk. Longitudinal studies on NaF uptake, conducted in the abdominal aorta only, showed unchanged uptake in postmenopausal women for nearly four years and varying uptake in prostate cancer patients over 1.5 years, despite constant or increasing calcium volume detected by computed tomography (CT). Thus, uncertainty remains about the transition from active arterial wall calcification marked by increased NaF uptake to less active or consolidated calcification detected by CT. The question of whether early-phase atherosclerosis and calcification can be modified remains also unanswered due to lack of intervention studies.

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Section: Discussionmentioning

confidence: 99%

Atherosclerosis Imaging with 18F-Sodium Fluoride PET

et al. 2020

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“…Location within each artery was determined by identification of the left main coronary artery bifurcation and IVUS still-frames were analyzed in the proximal 15 mm of the LAD utilizing ImageJ (NIH) software as previously described (19, 26, 27). External elastic lamina (EEL) cross-sectional area is indicated with a red dashed line in Figure 2A.…”

Section: Methodsmentioning

confidence: 99%

“…There remains a need for experimental animal studies to determine a causal role of cEAT in CAD progression (16). To this end, we have developed an animal model, the Ossabaw miniature swine, which naturally recapitulates human components of MetS and CAD (19, 20). We previously examined the effect of cEAT removal from the middle segment of the left anterior descending coronary artery (LAD) in Ossabaw swine using an intra-artery control, demonstrating that CAD progression was attenuated in the surgical region, compared to adjacent regions (21).…”

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confidence: 99%

Epicardial Adipose Tissue Removal Potentiates Outward Remodeling and Arrests Coronary Atherogenesis

McKenney‐Drake

Rodenbeck

Bruning

et al. 2017

The Annals of Thoracic Surgery

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Background Peri-coronary epicardial adipose tissue (cEAT) serves as a metabolic and paracrine organ that contributes to inflammation and is associated with macrovascular coronary artery disease (CAD) development. While there is a strong correlation in humans between cEAT volume and CAD severity, there remains a paucity of experimental data demonstrating a causal link of cEAT to CAD. The current study tested the hypothesis that surgical resection of cEAT attenuates inflammation and CAD progression. Methods Female Ossabaw miniature swine (n=12) were fed an atherogenic diet for 8 months and randomized into sham (n=5) or adipectomy (n=7) groups. Both groups underwent a thoracotomy, opening of the pericardial sac, and placement of radio-opaque clips to mark the proximal left anterior descending artery. Adipectomy swine underwent removal of 1–1.5 cm2 of cEAT from the proximal artery. Following sham or adipectomy, CAD severity was assessed with intravascular ultrasound. Swine recovered for an additional 3 months on atherogenic diet and CAD was assessed immediately prior to euthanasia. Artery sections were processed for histological and immunohistochemical analysis. Results CAD severity, as assessed by percent stenosis, was reduced in the adipectomy cohort compared to shams; however, plaque size remained unaltered, while sham-operated swine developed greater plaque sizes. Adipectomy resulted in an expanded arterial diameter, similar to the Glagov phenomenon of positive outward remodeling. No differences in inflammatory marker expression were observed. Conclusions These data indicate that cEAT resection did not alter inflammatory marker expression, but arrested CAD progression through increased positive outward remodeling and arrest of atherogenesis.

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“…Here, we conducted a repeat cross-sectional analysis of metabolic syndrome development in Ossabaw swine during atherogenic diet feeding for 6, 9, and 12 months, as described in the associated research study [1] . Ossabaw swine on atherogenic diet had increased body weight, hypertension, and dyslipidemia, compared to lean controls ( Table 1 ).…”

Section: Datamentioning

confidence: 99%

“…Increased body weight, hypertension, and increased plasma cholesterol and triglycerides are described in Table 1 . For more detailed interpretations and conclusions about the data, see our associated research study, “Biphasic alterations in coronary smooth muscle Ca 2+ regulation during coronary artery disease progression in metabolic syndrome” McKenney-Drake, et al (2016) [1] .…”

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Repeat cross-sectional data on the progression of the metabolic syndrome in Ossabaw miniature swine

et al. 2016

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Ossabaw miniature swine were fed an excess calorie, atherogenic diet for 6, 9, or 12 months. Increased body weight, hypertension, and increased plasma cholesterol and triglycerides are described in Table 1. For more detailed interpretations and conclusions about the data, see our associated research study, “Biphasic alterations in coronary smooth muscle Ca2+ regulation during coronary artery disease progression in metabolic syndrome” McKenney-Drake, et al. (2016) [1].

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Biphasic alterations in coronary smooth muscle Ca2+ regulation in a repeat cross-sectional study of coronary artery disease severity in metabolic syndrome

Cited by 14 publications

References 34 publications

Atherosclerosis Imaging with 18F-Sodium Fluoride PET

Atherosclerosis Imaging with 18F-Sodium Fluoride PET

Epicardial Adipose Tissue Removal Potentiates Outward Remodeling and Arrests Coronary Atherogenesis

Repeat cross-sectional data on the progression of the metabolic syndrome in Ossabaw miniature swine

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