Biperiden in the Treatment of Cocaine/Crack Dependence

Ramos, Anna Carolina; Dieckmann, Luiz Henrique Junqueira; Galduróz, José Carlos Fernandes

doi:10.1016/b978-0-12-803750-8.00066-x

Cited by 2 publications

(3 citation statements)

References 53 publications

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“…143 Biperiden abuse also occurs among people who have previously abused other substances. 144 insomnia. 141 Recently, scopolamine abuse has been noted among USA prisoners with prior history of abuse (mainly cocaine and heroin), using crushed scopolamine tablets for smoking.…”

Section: Current Social and Cultural Impactmentioning

confidence: 99%

“…Presently, the most commonly abused anticholinergic drug is trihexyphenidyl because of its strong euphorigenic effect . Biperiden abuse also occurs among people who have previously abused other substances . Albeit a less potent anticholinergic than trihexyphenidyl, it has a strong potential to abuse, causing various mood disorders and (upon withdrawal) dysphoria, fatigue, lack of motivation, and insomnia .…”

Section: Current Social and Cultural Impactmentioning

confidence: 99%

See 1 more Smart Citation

DARK Classics in Chemical Neuroscience: Atropine, Scopolamine, and Other Anticholinergic Deliriant Hallucinogens

Lakstygal

Колесникова

Khatsko

et al. 2018

ACS Chem. Neurosci.

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Anticholinergic drugs based on tropane alkaloids, including atropine, scopolamine, and hyoscyamine, have been used for various medicinal and toxic purposes for millennia. These drugs are competitive antagonists of acetylcholine muscarinic (M-) receptors that potently modulate the central nervous system (CNS). Currently used clinically to treat vomiting, nausea, and bradycardia, as well as alongside other anesthetics to avoid vagal inhibition, these drugs also evoke potent psychotropic effects, including characteristic delirium-like states with hallucinations, altered mood, and cognitive deficits. Given the growing clinical importance of anti-M deliriant hallucinogens, here we discuss their use and abuse, clinical importance, and the growing value in preclinical (experimental) animal models relevant to modeling CNS functions and dysfunctions.

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Section: Current Social and Cultural Impactmentioning

confidence: 99%

Section: Current Social and Cultural Impactmentioning

confidence: 99%

DARK Classics in Chemical Neuroscience: Atropine, Scopolamine, and Other Anticholinergic Deliriant Hallucinogens

Lakstygal

Колесникова

Khatsko

et al. 2018

ACS Chem. Neurosci.

View full text Add to dashboard Cite

show abstract

“…A similar approach has been proposed by the controversial Peruvian psychiatrist Teobaldo Llosa, who recommends the use of coca leaves for the treatment of cocaine addicts. Its treatment is known as "substitution of consumption" or "cocalization therapy" (Llosa & Chang-Fung, 2007;Llosa, 2010) and consists in the ingestion of capsules of coca flour (or variations), with or without the addition of alkaline substances, accompanied by a cup of coca tea, prepared with one or two bags in boiled water. In the Takiwasi Center, coca is used as well, this time in its medicinal extract form as a diet plant given to drug addicts during the dieta, as it reduces the withdrawal syndrome, restores normal sleep and increases dream activity.…”

Section: Coca Leaf To Treat Cocaine Addictionmentioning

confidence: 99%

Plant based assisted therapy for the treatment of substance use disorders - part 1. The case of takiwasi center and other similar experiences

Politi,

Friso,

Mabit

2018

culturaydroga

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Objective. This article aims to give an overview of the major American centers using traditional herbal medicine or their derivatives in the treatment of substance dependence. Methodology. For the purpose of this article we have considered a small number of plants hailing from South, Central and North America. The research has been based on scientific literature, information exchange with treatment centers, internet searches and the personal experience of the authors. Results and discussion. Results show the relevance of certain psychoactive plants well known also for inducing modified states of consciousness (MSCs) including Ayahuasca, Coca, Wachuma, Tobacco, Psilocybe mushrooms, Salvia divinorum and Peyote. Conclusions. Plant based assisted therapy for the treatment of substance use disorders appear to be a promising field of research, although validation of the clinical outcomes need to be improved for the majority of the analyzed cases.

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Biperiden in the Treatment of Cocaine/Crack Dependence

Cited by 2 publications

References 53 publications

DARK Classics in Chemical Neuroscience: Atropine, Scopolamine, and Other Anticholinergic Deliriant Hallucinogens

DARK Classics in Chemical Neuroscience: Atropine, Scopolamine, and Other Anticholinergic Deliriant Hallucinogens

Plant based assisted therapy for the treatment of substance use disorders - part 1. The case of takiwasi center and other similar experiences

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