Bioverfügbarkeit von Sotalol bei verkürzter gastrointestinaler Passage

Abstract

Effective enteral medication with sotalol in patients with short residual bowel is possible. Normal plasma concentrations can be achieved by administering doses according to the manufacturers' instructions. In case of severe short bowel syndrome, the measurements of plasma concentrations may be beneficial in supervising dose-adjustment.

The Impact of Intestinal Failure on Oral Drug Absorption: A Review

“…Sotalol has been successfully utilized to manage atrial fibrillation in two patients with short bowel syndrome. 25 Drug doses were adjusted, above usual dosage guidelines, utilizing serum drug concentrations as a guide.…”