Biotypes of functional brain engagement during emotion processing differentiate heterogeneity in internalizing symptoms and interpersonal violence histories among adolescent girls

Sellnow, Kyrie; Sartin-Tarm, Anneliis; Ross, M. A.; Weaver, Shelby; Cisler, Josh M.

doi:10.1016/j.jpsychires.2019.12.002

Cited by 15 publications

(7 citation statements)

References 37 publications

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“…Anxiety and impulsivity represent key transdiagnostic dimensions of psychopathology yet their interaction and contribution to emotional disorders in adolescence remains controversial (Jakuszkowiak-Wojten et al 2015) and previous findings of internalizing disorders on the symptomatic and neurobiological level remained inconsistent (Sellnow et al 2020;Kaczkurkin et al 2020;Shackman et al 2013). Combining a large adolescent sample consisting of 2437 internalizing patients aged 9-10 years with a data-driven clustering approach, we identified two distinct subtypes of internalizing patients with comparably elevated levels of anxiety but different levels of impulsivity.…”

Section: Discussionmentioning

confidence: 77%

Anxiety-impulsivity subtypes in adolescent internalizing disorder are characterized by distinguishable neurodevelopmental, neurocognitive and clinical trajectory signatures

Fan

Kuang

et al. 2021

Preprint

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Background Anxiety and impulsivity represent transdiagnostic pathology dimensions yet their interaction and contribution to emotional disorders in adolescence and to disease development remain controversial, and previous studies indicate heterogeneity within the broad category of internalizing disorders. Methods A combination of hierarchical and non-hierarchical clustering strategies was employed to determine impulsivity-related subtypes (based on the facets of negative urgency, lack of planning, lack of perseverance, sensation seeking and positive urgency in UPPS-P scales) in a large cohort of adolescents with internalizing disorders (n=2437) from Adolescent Brain Cognitive Development (ABCD) Study. Linear mixed-effect models were employed to determine cortical thickness alterations of the subtypes. Results Data-driven clustering identified two distinct subtypes of internalizing patients (subtype 1/subtype 2) with comparable levels of increased anxiety yet distinguishable levels of impulsivity, i.e., enhanced (subtype 1) or decreased (subtype 2) compared to healthy controls. Subtype 1 was further characterized by thicker prefrontal and temporal cortical regions involved in regulatory control and fear processing, while subtype 2 did not demonstrate significant thickness alterations. The differential neuroanatomical profiles remained stable over the two-year follow-up, while the two subtypes had different neurodevelopmental trajectories. Subtype 1 additionally reported more psychopathology and dysfunctionality including higher suicidal ideation, depressive symptoms and transition rates to externalizing disorders during follow-up as well as impaired neurocognitive and educational performance compared to subtype 2. Moreover, for subtype 1, anxiety at baseline (9-10 years) was significantly positively associated with impulsivity (lack of perseverance) at 2-year follow-up, while in subtype 2, baseline anxiety was significantly negatively associated with impulsivity (sensation seeking) at 2-year follow-up. Conclusions Our results demonstrate an impulsivity-dependent heterogeneity in adolescent internalizing disorders, with high-impulsivity patients being characterized by neurodevelopmental delay at the neural and cognitive levels. Individuals with elevated impulsivity are at a greater risk to develop behavioral dysregulation over the following two years and may thus require specific early interventions.

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Section: Discussionmentioning

confidence: 77%

Anxiety-impulsivity subtypes in adolescent internalizing disorder are characterized by distinguishable neurodevelopmental, neurocognitive and clinical trajectory signatures

Fan

Kuang

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Neuroimaging is an attractive tool for mapping symptoms to biology. Previous efforts to account for heterogeneity have often explored brain-wide patterns of activation or connectivity to identify "biotypes," subtypes of a particular form of psychopathology that differ in their neurophysiological features (8)(9)(10). The identification of such subgroups may in turn improve our understanding of variance in outcomes and response to treatment.…”

mentioning

confidence: 99%

Brain-Based Biotypes of Psychiatric Vulnerability in the Acute Aftermath of Trauma

Stevens

Harnett

Lebois

et al. 2021

AJP

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“…The impact of IPV on emotional processing varies across individuals, with distinct patterns of neural circuitry activation demonstrating heterogeneity in symptom internalization among survivors ( Sellnow et al, 2020 ). Structural brain differences among IPV survivors compared to non-victims have been correlated to a history of IPV-related TBI ( Daugherty et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Brain Injury and Mental Health Among the Victims of Intimate Partner Violence: A Case-Series Exploratory Study

et al. 2021

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Intimate partner violence (IPV) survivors frequently report face, head, and neck as their injury site. Many mild traumatic brain injuries (TBIs) are undiagnosed or underreported among IPV survivors while these injuries may be linked to changes in brain function or pathology. TBI sustained due to IPV often occurs over time and ranges in severity. The aim of this case-series study was to explore risk factors, symptoms, and brain changes unique to survivors of intimate partner violence with suspicion of TBI. This case-series exploratory study examines the potential relationships among IPV, mental health issues, and TBI. Participants of this study included six women: 3 women with a history of IPV without any experience of concussive blunt force to the head, and 3 women with a history of IPV with concussive head trauma. Participants completed 7T MRI of the brain, self-report psychological questionnaires regarding their mental health, relationships, and IPV, and the Structured Clinical Interview. MRI scans were analyzed for cerebral hemorrhage, white matter disturbance, and cortical thinning. Results indicated significant differences in resting-state connectivity among survivors of partner violence as well as differences in relationship dynamics and mental health symptoms. White matter hyperintensities are also observed among the survivors. Developing guidelines and recommendations for TBI-risk screening, referrals, and appropriate service provision is crucial for the effective treatment of TBI-associated IPV. Early and accurate characterization of TBI in survivors of IPV may relieve certain neuropsychological consequences.

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Biotypes of functional brain engagement during emotion processing differentiate heterogeneity in internalizing symptoms and interpersonal violence histories among adolescent girls

Cited by 15 publications

References 37 publications

Anxiety-impulsivity subtypes in adolescent internalizing disorder are characterized by distinguishable neurodevelopmental, neurocognitive and clinical trajectory signatures

Anxiety-impulsivity subtypes in adolescent internalizing disorder are characterized by distinguishable neurodevelopmental, neurocognitive and clinical trajectory signatures

Brain-Based Biotypes of Psychiatric Vulnerability in the Acute Aftermath of Trauma

Brain Injury and Mental Health Among the Victims of Intimate Partner Violence: A Case-Series Exploratory Study

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