Biotypes analysis of Corynebacterium glutamicum growing in dicarboxylic acids demonstrates the existence of industrially-relevant intra-species variations

Pérez-García, Fernando; Vasco-Cárdenas, María F.; Barreiro, Carlos

doi:10.1016/j.jprot.2016.06.030

Cited by 3 publications

(1 citation statement)

References 72 publications

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“…The yield improvement of microbial products has been traditionally faced up by means of: (i) treatment with mutagenic agents (e.g., nitrogen mustards, ultraviolet irradiation, X-ray); (ii) increasing the biosynthetic genes; or (iii) redirecting the metabolic precursors [ 73 ]. As a consequence, a promising strategy is metabolic engineering (see Table 1 ), which includes: (i) the overexpression of carotenoid biosynthetic genes (e.g., crtYB gene); (ii) the metabolic flow increase towards the synthesis of specific pathway precursor molecules (e.g., geranylgeranyl-pyrophosphate synthase encoding gene ( crtE )), or (iii) the supplementation with carotenogenesis precursors (e.g., mevalonate) [ 20 , 47 , 62 , 74 , 75 ].…”

Section: Biotechnology-based Improvement Of Astaxanthin Productionmentioning

confidence: 99%

Biosynthesis of Astaxanthin as a Main Carotenoid in the Heterobasidiomycetous Yeast Xanthophyllomyces dendrorhous

Barredo¹,

Garcı́a-Estrada

Kosalková

et al. 2017

JoF

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103

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Carotenoids are organic lipophilic yellow to orange and reddish pigments of terpenoid nature that are usually composed of eight isoprene units. This group of secondary metabolites includes carotenes and xanthophylls, which can be naturally obtained from photosynthetic organisms, some fungi, and bacteria. One of the microorganisms able to synthesise carotenoids is the heterobasidiomycetous yeast Xanthophyllomyces dendrorhous, which represents the teleomorphic state of Phaffia rhodozyma, and is mainly used for the production of the xanthophyll astaxanthin. Upgraded knowledge on the biosynthetic pathway of the main carotenoids synthesised by X. dendrorhous, the biotechnology-based improvement of astaxanthin production, as well as the current omics approaches available in this yeast are reviewed in depth.

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Section: Biotechnology-based Improvement Of Astaxanthin Productionmentioning

confidence: 99%

Biosynthesis of Astaxanthin as a Main Carotenoid in the Heterobasidiomycetous Yeast Xanthophyllomyces dendrorhous

Barredo¹,

Garcı́a-Estrada

Kosalková

et al. 2017

JoF

Self Cite

103

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Astaxanthin production and technology in Vietnam and other Asian countries

Tam

Hồng

Ambati

et al. 2021

Global Perspectives on Astaxanthin

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Bioactive Insecticides from Chemometric Diverse Ant-Associated Symbionts Streptomyces novaecaesareae and Streptomyces nojiriensis against the Fall Armyworm Larvae

Lima,

Joly,

Moraes

et al. 2024

Insects

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The Streptomyces genus has long been recognized as a prolific and valuable source of diverse secondary metabolites. These metabolites contribute significantly to the intricate chemical diversity exhibited by Streptomyces, making them an indispensable reservoir for drug discovery, agricultural applications, and industrial processes. Exploiting the potential of these natural compounds holds the promise of ushering in a new era in insect pest management, reducing reliance on synthetic chemicals and fostering ecologically sustainable solutions. This study dives into the realm of chemo diversity within isolates of Streptomyces nojiriensis and Streptomyces novaecaesareae, with a specific focus on the production of insecticidal compounds. We explored chromatographic techniques for the identification and isolation of insecticidal compounds, and two bioactive compounds were identified in extracts of S. novaecaesareae. Valinomycin was identified from hexanic extracts of strain Asp59, while naphthomycin from ethyl acetate extracts of strain Asp58. These compounds showed insecticidal activity against first instars of Spodoptera frugiperda (Asp59: LC50 = 10.82 µg/µL, LC90 = 26.25 µg/µL; Asp58: LC50 = 15.05 µg/µL, LC90 = 38.84 µg/µL). Notably, this is the first report of naphthomycin as an insecticidal compound. The present study suggests that valinomycin and naphthomycin may be a novel biological source for the control of Spodoptera frugiperda in early stages.

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Biotypes analysis of Corynebacterium glutamicum growing in dicarboxylic acids demonstrates the existence of industrially-relevant intra-species variations

Cited by 3 publications

References 72 publications

Biosynthesis of Astaxanthin as a Main Carotenoid in the Heterobasidiomycetous Yeast Xanthophyllomyces dendrorhous

Biosynthesis of Astaxanthin as a Main Carotenoid in the Heterobasidiomycetous Yeast Xanthophyllomyces dendrorhous

Astaxanthin production and technology in Vietnam and other Asian countries

Bioactive Insecticides from Chemometric Diverse Ant-Associated Symbionts Streptomyces novaecaesareae and Streptomyces nojiriensis against the Fall Armyworm Larvae

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