Biotransformation of paraoxon andp-nitrophenol by isolated perfused mouse livers

Sultatos, Lester G.; Minor, Lerna D.

doi:10.1016/0300-483x(85)90051-4

Cited by 11 publications

(6 citation statements)

References 21 publications

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“…In the in vitro experiments, compared to the detoxication by CbxE or A-esterases, very little PO was detoxified by other pathways when both CbxE and A-esterases were inhibited (Table 2). Similar observations on mouse livers have also been reported (16).…”

Section: Discussionsupporting

confidence: 89%

“…The detoxication pathways of PO described earlier have been well characterized; p-nitrophenol (PNP) is a common product of either CbxE phosphorylation or Aesterase hydrolysis (16). The present study was designed to investigate the relative contributions of those two major detoxication routes under the condition of high tissue concentration and low PO level.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Detoxication of paraoxon by rat liver homogenate and serum carboxylesterases and A-esterases*

Tang

Chambers

1999

J. Biochem. Mol. Toxicol.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Detoxication of paraoxon by rat liver homogenate and serum carboxylesterases and A-esterases*

Tang

Chambers

1999

J. Biochem. Mol. Toxicol.

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“…When it is activated via oxidative desulfuration to form its oxygen analog and active metabolite paraoxon (IC50 = 10"aM [42]), it is a potent inhibitor of AChE (EC 3. [20].…”

Section: Metabolismmentioning

confidence: 99%

A Physiologically Based Pharmacokinetic and Pharmacodynamic Model for Paraoxon in Rainbow Trout

Abbas

Hayton

1997

Toxicology and Applied Pharmacology

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Trout were exposed to an aqueous solution of 75 ng/ml paraoxon for 5 days at 12 degrees C. The relationships among paraoxon concentration in water and target organs, AChE inhibition, and carboxylesterase (CaE) detoxification of paraoxon were characterized quantitatively by development of a PBPK-PD model. The PKPD model structure consisted of brain, heart, liver, kidney, and remainder of the body, which were interconnected by blood circulation. The paraoxon tissue/blood partition coefficients were: plasma/water, 1.46; liver/plasma, 5.89; brain/plasma, 3.90; heart/plasma, 2.91; kidney/plasma, 0.45; and blood/plasma, 0.91. Turnover of AChE was characterized from a dose-response study, in which its zero-order synthesis rate and first-order degradation rate constant were determined in several tissues; for brain they were 7.67 pmol/min and 7.31 x 10(-5) hr(-1). The uptake and depuration clearances of paraoxon (Cl(u) = 0.651 and Cl(d) = 0.468 ml min(-1) g body wt(-1)) were determined using a compartmental model. During continuous water exposure to paraoxon, AChE activity in the tissues declined to new steady state values that were maintained by the synthesis of new AChE. CaE was shown by simulation to be an important pathway for detoxification of paraoxon.

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“…Perfusion of human kidneys (isolated from cadavers) with 4-nitrophenol resulted in the formation of the glucuronide and sulfate conjugates (Diamond et al 1982). Sulfate conjugates were found predominantly in mice livers perfused with low concentrations (4 µM) of 4-nitrophenol (Sultatos and Minor 1985). However, as the concentration of 4-nitrophenol was increased, unchanged 4-nitrophenol and the glucuronide appeared in the effluent, indicating the presence of saturation kinetics.…”

Section: Metabolismmentioning

confidence: 96%

Glauconite as a sorbent of 4-nitrophenol

Makhova¹,

Doronin²

2021

CBE

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The sorption properties of glauconite from Beloozersk deposits (Saratov region) for 4-nitrophenol (4-NF) have been investigated. The effect of glauconite on pH and 4-nitrophenol structure in solution is estimated. It is shown that glauconite increases pH of aqueous environment to 8 and shifts the equilibrium towards the formation of aci-form 4-NF. The conditions of sorption 4-NF by glauconite are established: the sorption time 20 min, the mass of the sorbent (0.50–1.0) g. The isotherm of sorption by 4-NF glauconite has been obtained; its interpretation is given using the Langmuir and Freundlich equations. The main quantitative sorption characteristics of glauconite such as recovery (R = 64%), distribution coefficient (D = 88) and the Langmuir and Freundlich constants for 4-nitrophenol are calculated. These experiments indicate the potential use of the glauconite from Beloozersk deposits (Saratov region) for 4-NP from various waters.

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Biotransformation of paraoxon andp-nitrophenol by isolated perfused mouse livers

Cited by 11 publications

References 21 publications

Detoxication of paraoxon by rat liver homogenate and serum carboxylesterases and A-esterases*

Detoxication of paraoxon by rat liver homogenate and serum carboxylesterases and A-esterases*

A Physiologically Based Pharmacokinetic and Pharmacodynamic Model for Paraoxon in Rainbow Trout

Glauconite as a sorbent of 4-nitrophenol

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