2017
DOI: 10.1039/c7ra04608a
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Biotransformation of dehydroepiandrosterone (DHEA) by environmental strains of filamentous fungi

Abstract: Study on the ability of selected filamentous fungus species to transform dehydroepiandrosterone was performed (DHEA) and interesting DHEA derivatives were obtained with high yield.

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citations
Cited by 22 publications
(12 citation statements)
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References 61 publications
(79 reference statements)
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“…Selecting species for metabolism testing should not be entirely based on literature data. Fusarium acuminatum KCh S1 and Mucor hiemalis KCh W2 provide hydroxylation only at the 7α position, similar to Aspergillus versicolor KCh TJ1, while Penicillium commune KCh W7 and Penicillium chrysogenum KCh S4 do not hydroxylate DHEA at C7, in contrast to literature data 21 , 22 . However, every strain should be treated individually.…”
Section: Introductioncontrasting
confidence: 83%
See 1 more Smart Citation
“…Selecting species for metabolism testing should not be entirely based on literature data. Fusarium acuminatum KCh S1 and Mucor hiemalis KCh W2 provide hydroxylation only at the 7α position, similar to Aspergillus versicolor KCh TJ1, while Penicillium commune KCh W7 and Penicillium chrysogenum KCh S4 do not hydroxylate DHEA at C7, in contrast to literature data 21 , 22 . However, every strain should be treated individually.…”
Section: Introductioncontrasting
confidence: 83%
“…The investigated compound is 3β,11α-dihydroxy-17a-oxa-D-homo-androst-5-en-17-one, and its spectral data are in accordance with the literature 46 . The 13 C NMR data for compound 8 show the appearance of signals, in comparison to compound 5 , at δ 171.73 ppm and at 82.43 ppm, which are characteristic for D-lactone 21 . Further inspection of NMR data revealed that the structure of the A-B ring of compound 5 remained unchanged, which confirms the lactonisation of a D ring.…”
Section: Resultsmentioning
confidence: 96%
“…The composition of product mixtures was established by 1 HNMR. The crude mixture was separated as described previously by preparative TLC (Silica Gel GF, 500 μm) and chloroform/methanol mixture (9:1, v/v) as an eluent 1921 . After elution products were detected under UV light (365 nm) then scraped from the plate and eluted with ethyl acetate to give pure fractions.…”
Section: Methodsmentioning
confidence: 99%
“…Steroid compounds are very common in pharmacy and medicine because of their variety of biological activities [ 1 , 2 , 3 ]. Hydroxylation of steroid compounds by microbial monooxygenases, which are similar to mammalian cytochromes P450, is a source of molecules of high biological activity and key intermediates in chemical synthesis [ 4 , 5 , 6 , 7 ]. The first known hydroxylated corticosteroid is cortisol (hydrocortisone), which is produced by the adrenal glands from cortisone by the 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) in response to stress and low blood glucose concentrations.…”
Section: Introductionmentioning
confidence: 99%
“…The first steroid aromatase inhibitor used in treatment was testolactone [ 36 ]. High activity of Baeyer-Villiger monooxygenase are characteristic to strains from the genera Penicillium , e.g., P. simplicissimum, P. lanosocoeruleum, P. commune or P. chrysogenum [ 6 , 37 , 38 ].…”
Section: Introductionmentioning
confidence: 99%