Biotransformation of carbamazepine by laccase-mediator system: Kinetics, by-products and toxicity assessment

Naghdi, Mitra; Taheran, Mehrdad; Brar, Satinder Kaur; Kermanshahi-pour, Azadeh; Verma, Mausam P.; Surampalli, Rao Y.

doi:10.1016/j.procbio.2018.02.009

Cited by 56 publications

(36 citation statements)

References 42 publications

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“…The products after CBZ interaction with native HRP-and LiP enzymes are presented in Figure S6a-c respectively. A detailed mass-spectrometric investigation on the products for CBZ (Scheme 3, compound a) transformation by laccase is given in [48]. The two main products detected were: 10,11-dihydro-10,11-dihydroxy-CBZ (DiOH-CBZ) (Scheme 3, compound b) and 10,11-dihydro-10,11-epoxy-CBZ (EP-CBZ) (compound c).…”

Section: Degradation Of Carbamazepine By Non-immobilized Enzymesmentioning

confidence: 99%

Removal of Diclofenac, Paracetamol, and Carbamazepine from Model Aqueous Solutions by Magnetic Sol–Gel Encapsulated Horseradish Peroxidase and Lignin Peroxidase Composites

et al. 2020

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Sustainable and green synthesis of nanocomposites for degradation of pharmaceuticals was developed via immobilization and stabilization of the biological strong oxidizing agents, peroxidase enzymes, on a solid support. Sol–gel encapsulated enzyme composites were characterized using electron microscopy (TEM, SEM), atomic force microscopy, FTIR spectroscopy, and thermogravimetric analysis. Horseradish peroxidase (HRP) and lignin peroxidase (LiP) were adsorbed onto magnetite nanoparticles and sol–gel encapsulated in a surface silica layer. Encapsulation enhanced the stability of the biocatalysts over time and thermal stability. The biocatalysts showed appreciable selectivity in oxidation of the organic drinking water pollutants diclofenac, carbamazepine, and paracetamol with improved activity being pharmaceutical specific for each enzyme. In particular, sol–gel encapsulated LiP- and HRP-based nanocomposites were active over 20 consecutive cycles for 20 days at 55 °C (24 h/cycle). The stability of the sol–gel encapsulated catalysts in acidic medium was also improved compared to native enzymes. Carbamazepine and diclofenac were degraded to 68% and 64% by sol–gel LiP composites respectively at pH 5 under elevated temperature. Total destruction of carbamazepine and diclofenac was achieved at pH 3 (55 °C) within 3 days, in the case of both immobilized HRP and LiP. Using NMR spectroscopy, characterization of the drug decomposition products, and decomposition pathways by the peroxidase enzymes suggested.

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Section: Degradation Of Carbamazepine By Non-immobilized Enzymesmentioning

confidence: 99%

Removal of Diclofenac, Paracetamol, and Carbamazepine from Model Aqueous Solutions by Magnetic Sol–Gel Encapsulated Horseradish Peroxidase and Lignin Peroxidase Composites

et al. 2020

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“…Moreover, recent evidence suggests that reaction conditions could play a determinant role in CBZ degradation. Naghdi et al [57] observed that addition of ABTS increased degradation of CBZ from 30% to 82% in 24 h by a laccase extract from T. versicolor, but when reaction conditions were optimized to 35 °C, pH 6, with 60 U L -1 of enzyme 25 concentration and 18 μM of mediator up to 95% removal was obtained. Further investigation should be done in order to find the conditions allowing CBZ degradation in the matrix.…”

Section: Effect Of Syringaldehyde Additionmentioning

confidence: 99%

Effect of redox mediators in pharmaceuticals degradation by laccase: A comparative study

Guardado

Belleville

Alanis

et al. 2019

Process Biochemistry

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“…This result highlights the potential in further applying lignin-degrading systems to nylon biodegradation. The use of laccase-mediator systems has since not focused on plastic, but on bioremediation of other compounds such as perfluoroctanesulfonate, carbamazepine, and non-steroidal antiinflammatory drugs (NSAIDs) (Luo et al, 2018;Naghdi et al, 2018;Apriceno et al, 2019).…”

Section: Naturally Occurring Activity From Enzymes That Degrade Naturmentioning

confidence: 99%

Bioengineering a Future Free of Marine Plastic Waste

et al. 2019

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Plastic waste has reached epidemic proportions worldwide, and the production of plastic continues to rise steadily. Plastic represents a diverse array of commonly used synthetic polymers that are extremely useful as durable, economically beneficial alternatives to other materials; however, despite the wide-ranging utility of plastic, the increasing accumulation of plastic waste in the environment has had numerous detrimental impacts. In particular, plastic marine debris can transport invasive species, entangle marine organisms, and cause toxic chemical bioaccumulation in the marine food web. The negative impacts of plastic waste have motivated research on new ways to reduce and eliminate plastic. One unique approach to tackle the plastic waste problem is to turn to nature's solutions for degrading polymers by leveraging the biology of naturally occurring organisms to degrade plastic. Advances in metagenomics, next generation sequencing, and bioengineering have provided new insights and new opportunities to identify and optimize organisms for use in plastic bioremediation. In this review, we discuss the plastic waste problem and possible solutions, with a focus on potential mechanisms for plastic bioremediation. We pinpoint two key habitats to identify plastic-biodegrading organisms: (1) habitats with distinct enrichment of plastic waste, such as those near processing or disposal sites, and (2) habitats with naturally occurring polymers, such as cutin, lignin, and wax. Finally, we identify directions of future research for the isolation and optimization of these methods for widespread bioremediation applications.

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Biotransformation of carbamazepine by laccase-mediator system: Kinetics, by-products and toxicity assessment

Cited by 56 publications

References 42 publications

Removal of Diclofenac, Paracetamol, and Carbamazepine from Model Aqueous Solutions by Magnetic Sol–Gel Encapsulated Horseradish Peroxidase and Lignin Peroxidase Composites

Removal of Diclofenac, Paracetamol, and Carbamazepine from Model Aqueous Solutions by Magnetic Sol–Gel Encapsulated Horseradish Peroxidase and Lignin Peroxidase Composites

Effect of redox mediators in pharmaceuticals degradation by laccase: A comparative study

Bioengineering a Future Free of Marine Plastic Waste

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