Biotransformation of anthocyanins from two purple-fleshed sweet potato accessions in a dynamic gastrointestinal system

Kubow, Stan; Iskandar, Michèle M.; Sabally, Kebba; Azadi, Behnam; Ekbatan, Shima Sadeghi; Kumarathasan, Premkumari; Das, Debajyoti; Prakash, Satya; Burgos, Gabriela; Felde, Thomas zum

doi:10.1016/j.foodchem.2015.06.105

Cited by 36 publications

(33 citation statements)

References 29 publications

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“…These anthocyanins are stable after heat treatment (Xu et al, 2015) and their antioxidant effects have been shown to be varietydependent (Kano et al, 2005). The total anthocyanin content of different varieties has been used as an indicator of the antioxidant activity of their extracts (Kubow et al, 2016). It was found to be highest for purple-fleshed and lowest for white-fleshed varieties (Teow et al, 2007) but was also related to the cyanidin-and peonidin-based chemical composition (Hu et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Identification and quantification of phenolic compounds responsible for the antioxidant activity of sweet potatoes with different flesh colours using high performance thin layer chromatography (HPTLC)

Lebot

Michalet

Legendre

2016

Journal of Food Composition and Analysis

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Section: Introductionmentioning

confidence: 99%

Identification and quantification of phenolic compounds responsible for the antioxidant activity of sweet potatoes with different flesh colours using high performance thin layer chromatography (HPTLC)

Lebot

Michalet

Legendre

2016

Journal of Food Composition and Analysis

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“…In that regard, probiotic supplementation has shown the capacity to enhance production of SCFAs [12,41] and to help in restoring overall metabolic capacity through regulation of the microbiota [25,42]. Furthermore, such models have been previously utilized by our research group to study the effect of digestion on biotransformation of polyphenols and anthocyanins along with their effects on SCFA production and metabolite toxicity on intestinal cells [43,44]. In the context of CDI, GI models have been utilized to study the efficacy of various antibiotics and their effect on C. difficile toxicity and commensal microbial communities [45].…”

mentioning

confidence: 99%

Probiotic Supplementation in a Clostridium difficile-Infected Gastrointestinal Model Is Associated with Restoring Metabolic Function of Microbiota

Gaisawat

MacPherson²,

Tremblay

et al. 2019

Microorganisms

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Clostridium (C.) difficile-infection (CDI), a nosocomial gastrointestinal disorder, is of growing concern due to its rapid rise in recent years. Antibiotic therapy of CDI is associated with disrupted metabolic function and altered gut microbiota. The use of probiotics as an adjunct is being studied extensively due to their potential to modulate metabolic functions and the gut microbiota. In the present study, we assessed the ability of several single strain probiotics and a probiotic mixture to change the metabolic functions of normal and C. difficile-infected fecal samples. The production of short-chain fatty acids (SCFAs), hydrogen sulfide (H 2 S), and ammonia was measured, and changes in microbial composition were assessed by 16S rRNA gene amplicon sequencing. The C. difficile-infection in fecal samples resulted in a significant decrease (p < 0.05) in SCFA and H 2 S production, with a lower microbial alpha diversity. All probiotic treatments were associated with significantly increased (p < 0.05) levels of SCFAs and restored H 2 S levels. Probiotics showed no effect on microbial composition of either normal or C. difficile-infected fecal samples. These findings indicate that probiotics may be useful to improve the metabolic dysregulation associated with C. difficile infection.Probiotics, defined as live microorganisms that impart beneficial effects on the host when given in adequate quantities [11], have shown beneficial effects in the GI tract such as improving metabolic function [12][13][14][15], counteracting infections [16][17][18], regulating immune function, decreasing GI disorder symptoms [16,[19][20][21], and potentially lowering the risk of developing colon cancer [22]. Most of the probiotics utilized to date are usually from the Lactobacilli, Bifidobacteria, and yeast (Saccharomyces) groups. The efficacy and proposed mechanisms of action of these microbes in regulating intestinal microbiota functions are generally strain-specific. Some probiotic strains are thought to produce antimicrobial metabolites such as bacteriocins, to lower the pH by generating hydrogen peroxide and SCFAs, or to restrict pathogenic growth by competing for essential nutrients and adherence onto the gut mucosal barrier [18,[23][24][25][26][27]. Several probiotics may reduce CDI-associated diarrhea and prevent primary CDI formation using some of the abovementioned mechanisms, but perhaps predominantly by inhibiting the adhesion of C. difficile in the intestine [28,29]. In the case of Saccharomyces (S.) boulardii, the mechanism was shown to involve the proteolytic hydrolysis of the CD enterotoxins A and B [30]. Although the Lactobacillus (L.) rhamnosus GG strain and S. boulardii have been studied the most in the context of CDI-associated diarrhea [9,31], several other strains such as Bifidobacterium (B.) longum and L. acidophilus CL1285 have also shown efficacy against antibiotic-associated diarrhea [32][33][34][35]. Furthermore, strains such as L. plantarum 299v have been shown to enhance microbial function in CDI patients recei...

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“…We assumed that the antioxidant capacity of PSP depends on its variety. 25,26 Next, our result showed that the combination of BSB and PSP (2:2) enhance SOD concentration compared tothe DM group. The previous study reported that isoflavone-rich content in soybean enhances the SOD activity through preventing superoxide anions to form H 2 O 2 .…”

Section: Discussionmentioning

confidence: 61%

The Evaluation of Dietary Black Soybean and Purple Sweet Potato on Insulin Sensitivity in Streptozotocin - Induced Diabetic Rats

Gofur¹,

Witjoro²,

Ningtiyas³

et al. 2019

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Introduction: Hyperglycemia mediates the production of excess free radicals and reduces endogenous antioxidant in type 2 diabetes mellitus (T2DM). Black soybean (BSB) is rich in antioxidant mainly from isoflavones, whereas the antioxidant of purple sweet potato (PSP) comes from high anthocyanin. The study aimed to evaluate the efficacy of BSB, PSP, and its combination on malondialdehyde (MDA), superoxide dismutase (SOD) concentrations, insulin and insulin receptor substrate-1 (IRS-1) expression in T2DM rats. Methods: T2DM induced by high-calorie diet for five weeks and then injected with a low dose of streptozotocin (30 mg/kg BW) intraperitoneally. The DM rats then treated with black soybean (DM + BSB), purple sweet potato (DM + PSP) and the combination of BSB and PSP 1:3, 2:2, 3:1 respectively (DM + C1-3). Treatments were given for thirty days. The effect of BSB, PSP and its combination evaluated by measuring SOD and MDA, necrosis in pancreas evaluated through hematoxylin-eosin (HE) and insulin and IRS-1 expression in pancreas through immunohistochemistry-fluorescence (IHC-F). Results: Our result indicated that there were no significant differences of BSB and the combination in decreasing MDA concentrations. The ratio of BSB and PSP combination of 2:2 increase SOD towards near normal, decrease necrosis, and improve insulin and IRS-1. Conclusion: The combination of BSB and PSP had the potential to improve insulin sensitivity through the increase of SOD, reduce necrosis, and improve insulin and IRS-1 expression. and Natural Sciences, Brawijaya University, Indonesia. Her research interest field is nutrigenomic. Currently, she has a research projects about garlic and their impact for health.

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Biotransformation of anthocyanins from two purple-fleshed sweet potato accessions in a dynamic gastrointestinal system

Cited by 36 publications

References 29 publications

Identification and quantification of phenolic compounds responsible for the antioxidant activity of sweet potatoes with different flesh colours using high performance thin layer chromatography (HPTLC)

Identification and quantification of phenolic compounds responsible for the antioxidant activity of sweet potatoes with different flesh colours using high performance thin layer chromatography (HPTLC)

Probiotic Supplementation in a Clostridium difficile-Infected Gastrointestinal Model Is Associated with Restoring Metabolic Function of Microbiota

The Evaluation of Dietary Black Soybean and Purple Sweet Potato on Insulin Sensitivity in Streptozotocin - Induced Diabetic Rats

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