Biotransformation of 4-chloro-2-nitrophenol into 5-chloro-2-methylbenzoxazole by a marine Bacillus sp. strain MW-1

Arora, Pankaj; Jain, Rakesh

doi:10.1007/s10532-011-9512-y

Cited by 33 publications

(64 citation statements)

References 19 publications

(17 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TK-2 [Figure 8]. A detoxification mechanism for 4C2NP transformation has been proposed for two Bacillus species [73,74]. In this mechanism, detoxification is initiated by the formation of 4C2AP, which acetylates into 4-chloro-2-acetaminophenol (4C2AAP).…”

Section: Introductionmentioning

confidence: 99%

Bacterial degradation of chlorophenols and their derivatives

2014

View full text Add to dashboard Cite

Chlorophenols (CPs) and their derivatives are persistent environmental pollutants which are used in the manufacture of dyes, drugs, pesticides and other industrial products. CPs, which include monochlorophenols, polychlorophenols, chloronitrophenols, chloroaminophenols and chloromethylphenols, are highly toxic to living beings due to their carcinogenic, mutagenic and cytotoxic properties. Several physico-chemical and biological methods have been used for removal of CPs from the environment. Bacterial degradation has been considered a cost-effective and eco-friendly method of removing CPs from the environment. Several bacteria that use CPs as their sole carbon and energy sources have been isolated and characterized. Additionally, the metabolic pathways for degradation of CPs have been studied in bacteria and the genes and enzymes involved in the degradation of various CPs have been identified and characterized. This review describes the biochemical and genetic basis of the degradation of CPs and their derivatives.

show abstract

Section: Introductionmentioning

confidence: 99%

Bacterial degradation of chlorophenols and their derivatives

2014

View full text Add to dashboard Cite

show abstract

“…Two different ways have been reported for removal of the nitro groups: (i) oxidative removal of nitro groups in which nitro groups are directly removed as nitrite ions via oxidative hydroxylation, and (ii) partial reduction of nitro groups in which nitro groups are reduced to hydroxylamines or amino groups by reduction mechanism. The partial reduction of nitro groups has been reported in the most cases of microbial degradation of CNAs [4], [5], [6], [7], [8], [9]. However, the oxidative removal of nitro groups has also been reported in the degradation of CNAs [1], [10], [11], [12].…”

Section: Introductionmentioning

confidence: 99%

Metabolism of 2-Chloro-4-Nitrophenol in a Gram Negative Bacterium, Burkholderia sp. RKJ 800

Arora

Jain

2012

PLoS ONE

Self Cite

View full text Add to dashboard Cite

A 2-Chloro-4-nitrophenol (2C4NP) degrading bacterial strain designated as RKJ 800 was isolated from a pesticide contaminated site of India by enrichment method and utilized 2C4NP as sole source of carbon and energy. The stoichiometric amounts of nitrite and chloride ions were detected during the degradation of 2C4NP. On the basis of thin layer chromatography, high performance liquid chromatography and gas chromatography-mass spectrometry, chlorohydroquinone (CHQ) and hydroquinone (HQ) were identified as major metabolites of the degradation pathway of 2C4NP. Manganese dependent HQ dioxygenase activity was observed in the crude extract of 2C4NP induced cells of the strain RKJ 800 that suggested the cleavage of the HQ to γ-hydroxymuconic semialdehyde. On the basis of the 16S rRNA gene sequencing, strain RKJ 800 was identified as a member of genus Burkholderia. Our studies clearly showed that Burkholderia sp. RKJ 800 degraded 2-chloro-4-nitrophenol via hydroquinone pathway. The pathway identified in a gram negative bacterium, Burkholderia sp. strain RKJ 800 was differed from previously reported 2C4NP degradation pathway in another gram-negative Burkholderia sp. SJ98. This is the first report of the formation of CHQ and HQ in the degradation of 2C4NP by any gram-negative bacteria. Laboratory-scale soil microcosm studies showed that strain RKJ 800 is a suitable candidate for bioremediation of 2C4NP contaminated sites.

show abstract

“…CAPs have been released into soil and water as the by-products during the synthesis of cosmetic dyes and chemicals. They may also release into soil because of microbial degradation of various chemicals including 3-chloronitrobenzene and 4-chloro-2-nitrophenol (4C2NP) [2,3].…”

Section: Introductionmentioning

confidence: 99%

“…The bacterial degradation of CAPs may be initiated by one of the following mechanisms: (i) the removal of ammonium ion from a CAP by a deaminase [1]; (ii) the ring cleavage of a CAP by an aminophenol dioxygenase [5]; (ii) the dehalogenation of a CAP by a dehalogenase [4]; and (iii) the acetylation of a CAP [2,3,6].…”

Section: Introductionmentioning

confidence: 99%

Metabolic pathway for degradation of 2-chloro-4-aminophenol by Arthrobacter sp. SPG

et al. 2014

View full text Add to dashboard Cite

A degradation pathway of 2-chloro-4-aminophenol (2C4AP) was studied in an Arthrobacter sp. SPG that utilized 2C4AP as its sole source of carbon and energy. The 2C4AP degradation was initiated by a 2C4AP-deaminase that catalyzed the conversion of 2C4AP into chlorohydroquinone (CHQ) with removal of ammonium ion. In the next step, a CHQ-dehalogenase dehalogenated CHQ to hydroquinone (HQ) that cleaved into γ-hydroxymuconic semialdehyde by a HQ-dioxygenase. The 2C4AP degradation was also investigated in sterile and non-sterile soil microcosms using strain SPG. The results show that the SPG cells degraded 2C4AP more rapidly in sterile soil than non-sterile soil. Our studies showed that strain SPG may be used for bioremediation of 2C4AP-contaminated sites. This is the first report of the 2C4AP degradation by any bacteria.

show abstract

Biotransformation of 4-chloro-2-nitrophenol into 5-chloro-2-methylbenzoxazole by a marine Bacillus sp. strain MW-1

Cited by 33 publications

References 19 publications

Bacterial degradation of chlorophenols and their derivatives

Bacterial degradation of chlorophenols and their derivatives

Metabolism of 2-Chloro-4-Nitrophenol in a Gram Negative Bacterium, Burkholderia sp. RKJ 800

Metabolic pathway for degradation of 2-chloro-4-aminophenol by Arthrobacter sp. SPG

Contact Info

Product

Resources

About