Biotransformation and disposition of hexachlorocyclopentadiene in fish

Podowski, A. A.; Sclove, Stanley L.; Pilipowicz, A.; Khan, M. A. Q.

doi:10.1007/bf01065837

Cited by 13 publications

(4 citation statements)

References 16 publications

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“…Based on the octanol–water partition coefficient of hexachlorocyclopentadiene (log K OW = 5.04; Table S3), this chemical should bioconcentrate. According to EPI Suite, the calculated bioconcentration factor (BCF) is equal to 3606 while with EUSES, a BCF of 3800 was estimated; 26 however, experiments carried out by Podowski and colleagues 27 have shown that this chemical is hardly bioconcentrated in fish, likely due to biotransformation. According to Spehar and co-workers, 28 the BCF of hexachlorocyclopentadiene for fathead minnow is 11.…”

Section: Resultsmentioning

confidence: 99%

Predicting Concentrations of Organic Chemicals in Fish by Using Toxicokinetic Models

Stadnicka

Schirmer

Ashauer

2012

Environ. Sci. Technol.

117

110

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Quantification of chemical toxicity continues to be generally based on measured external concentrations. Yet, internal chemical concentrations have been suggested to be a more suitable parameter. To better understand the relationship between the external and internal concentrations of chemicals in fish, and to quantify internal concentrations, we compared three toxicokinetic (TK) models with each other and with literature data of measured concentrations of 39 chemicals. Two one-compartment models, together with the physiologically based toxicokinetic (PBTK) model, in which we improved the treatment of lipids, were used to predict concentrations of organic chemicals in two fish species: rainbow trout (Oncorhynchus mykiss) and fathead minnow (Pimephales promelas). All models predicted the measured internal concentrations in fish within 1 order of magnitude for at least 68% of the chemicals. Furthermore, the PBTK model outperformed the one-compartment models with respect to simulating chemical concentrations in the whole body (at least 88% of internal concentrations were predicted within 1 order of magnitude using the PBTK model). All the models can be used to predict concentrations in different fish species without additional experiments. However, further development of TK models is required for polar, ionizable, and easily biotransformed compounds.

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Section: Resultsmentioning

confidence: 99%

Predicting Concentrations of Organic Chemicals in Fish by Using Toxicokinetic Models

Stadnicka

Schirmer

Ashauer

2012

Environ. Sci. Technol.

117

110

View full text Add to dashboard Cite

show abstract

“…The average value of each experiment with at least five replicates was used to calculate the mean with standard deviation for each series of at least three separate experiments. The difference between means of control and other groups was tested for statistical significance using one-way ANOVA (Podowski et al, 1991) using Graphpad software (Anonymous, 2005). The value of P 5 0.05 for the respective degrees of freedom was taken to be statistically significant.…”

Section: Discussionmentioning

confidence: 99%

Effect of temperature on heavy metal toxicity to earthworm Lumbricus terrestris (Annelida: Oligochaeta)

Khan

Ahmed

Salazar

et al. 2007

Environmental Toxicology

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Earthworms (Lumbricus terrestris) acclimated at 2 degrees C above their habitat temperature (10-12 degrees C) showed about 5% increase in basal rate of oxygen consumption, which increased to about 38% in 14-16 degrees C- and 40% in 16-18 degrees C-, but decreased by 84% in 20-22 degrees C-acclimated worms. Temperature also increased the blood hemoglobin (Hb) concentration, which decreased slightly in 20-22 degrees C-acclimated worms. The worms acclimated at 20-22 degrees C showed their blood to be hypovolemic than that of 10-12 degrees C worms indicating dehydration. Pre-exposure of 10-14 degrees C-acclimated worms to sublethal concentrations of zinc, copper, and lead did not significantly affect the rate of respiration. However, at higher temperatures all these metals inhibited oxygen consumption; zinc, lead, and cadmium by approximately 11% and copper by approximately 18% of that at 14-16 degrees C. At 20-22 degrees C, the respiration was further inhibited, 36% by copper, 18% by cadmium, and approximately 10% by lead and zinc. Copper, lead, and zinc decreased the temperature-enhanced increase in blood Hb concentration at all temperatures. In 20-22 degrees C-acclimated worms heavy metal exposure slightly lowered the oxygen affinity of Hb as well as caused shifts in carbon monoxide difference spectra. The acute toxicity of these metals was not affected by a 2 degrees C rise in acclimation temperature but increased by 17% (lead), 33% (copper), and 5% (zinc) in 14-16 degrees C- and by 40% (lead), 149% (copper), and 132% (zinc) in 20-22 degrees C-acclimated worms. The increase in toxicity of metals caused by high temperatures may be due to limiting the scope of aerobic metabolism (oxygen extraction, transport, and utilization) via quantitative and qualitative effects on Hb. This terrestrial species appears to be tolerant of slight increases in habitat temperature, such as that expected with current global climate change.

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“…The values for individual experiments were polled to calculate mean value with standard deviation/error to make comparisons. The statistical significance of the difference between means was determined by using one-way ANOVA (Podowski et al, 1991). The value of P 0.05 was taken to be significant (Snedecor, 1956).…”

Section: Discussionmentioning

confidence: 99%

Effect of temperature on heavy metal toxicity to juvenile crayfish,Orconectes immunis (Hagen)

et al. 2006

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The acute toxicity of four selected heavy metals to juvenile crayfish Orconectes immunis (Hagen) (1-2 g wet body wt. each) at room temperature increased in the following order: cadmium (x3) < copper (x10) < zinc (x2) < lead. The toxicity of these metals to crayfish acclimated at 17, 20, 23/24, and 27 degrees C increased with temperature (by 7-20% between 20 and 24 degrees C and 14-26% between 20 and 27 degrees C) as judged by the lowering of LT(50) (time to kill 50% of test animals at a fixed concentration) values. A 4 degrees C rise in temperature (from 20 to 24 degrees C), which increased the toxicity of copper by about 7%, increased the rate of oxygen consumption by about 34%. Heavy metals inhibited the rate of oxygen consumption at all temperatures. In 20 degrees C-acclimated crayfish, copper caused about 17% inhibition of oxygen consumption compared to about 7-12% by other metals including the most toxic cadmium. A 3-4 degrees C rise in temperature tripled the inhibitory effect of copper (20%), cadmium and zinc (26 and 18%, respectively), but not of lead, on oxygen consumption. A 7 degrees C-rise in temperature (from 20 to 27 degrees C) increased the inhibitory effect of heavy metals, including lead, on oxygen consumption by up to 54% in the case of copper. The data indicate that rising global temperatures (currently 0.60 degrees C) associated with climate change can have the potential to increase the sensitivity of aquatic animals to heavy metals in their environment.

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Biotransformation and disposition of hexachlorocyclopentadiene in fish

Cited by 13 publications

References 16 publications

Predicting Concentrations of Organic Chemicals in Fish by Using Toxicokinetic Models

Predicting Concentrations of Organic Chemicals in Fish by Using Toxicokinetic Models

Effect of temperature on heavy metal toxicity to earthworm Lumbricus terrestris (Annelida: Oligochaeta)

Effect of temperature on heavy metal toxicity to juvenile crayfish,Orconectes immunis (Hagen)

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