Biotoxicity of nanoparticles: effect of natural organic matter

Lee, Sungyun; Kim, Kitae; Shon, Ho Kyong; Kim, Sang Don; Cho, Jaeweon

doi:10.1007/s11051-010-0204-z

Cited by 70 publications

(40 citation statements)

References 40 publications

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“…102,123,124 The bacterial toxicity of CuO and Fe 0 NPs was mitigated in the presence of FA, mostly as a result of hindering the direct contact with cells. The lower toxicity of Fe 0 , CuO or Ag NPs towards bacteria, crustaceans and fish has been observed in the presence of organic matter.…”

Section: Influence On Toxicitymentioning

confidence: 99%

The nanoparticle biomolecule corona: lessons learned – challenge accepted?

et al. 2015

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Besides the wide use of engineered nanomaterials (NMs) in technical products, their applications are not only increasing in biotechnology and biomedicine, but also in the environmental field. While the physico-chemical properties and behaviour of NMs can be characterized accurately under idealized conditions, this is no longer the case in complex physiological or natural environments. Herein, proteins and other biomolecules rapidly bind to NMs, forming a protein/biomolecule corona that critically affects the NMs' (patho)biological and technical identities. As the corona impacts the in vitro and/or in vivo NM applications in humans and ecosystems, a mechanistic understanding of its relevance and of the biophysical forces regulating corona formation is mandatory. Based on recent insights, we here critically review and present an updated concept of corona formation and evolution. We comment on how corona signatures may be linked to effects at the nano-bio interface in physiological and environmental systems. In order to comprehensively analyse corona profiles and to mechanistically understand the coronas' biological/ecological impact, we present a tiered multidisciplinary approach. To stimulate progress in this field, we introduce the potential impact of the corona for NM-microbiome-(human)host interactions and the novel concept of 'nanologicals', i.e., the nanomaterial-specific targeting of molecular machines. We conclude by discussing the relevant challenges that still need to be resolved in this field.

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Section: Influence On Toxicitymentioning

confidence: 99%

The nanoparticle biomolecule corona: lessons learned – challenge accepted?

et al. 2015

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“…This coating by DOM may limit the release of ions from ENPs into the water phase (Li, Zhu & Lin, ; Levard et al ., ), in contrast to the process of weathering, which can result in the loss of coatings (Mahendra et al ., ). It could also prevent ENP agglomeration, which appears to be more effective with increasing hydrophobicity (Lee et al ., ) or aromaticity (Pakarinen et al ., ) of DOM (Fig. ), and thus reduce the ecotoxicological potential of ENPs (Blinova et al ., ; Dasari & Hwang, ; Van Hoecke et al ., ; but see Yang et al ., ).…”

Section: Nanoparticle Interactions With Environmental Factors and Chementioning

confidence: 99%

Effects of nanoparticles in fresh waters: risks, mechanisms and interactions

et al. 2016

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SUMMARY1. Ecotoxicology is often criticised for its simplistic approach, which does not normally consider the complexity of field conditions. Simple laboratory experiments can still be useful, however, especially for assessing effects of emerging stressors such as nanoparticles, which exhibit fates, exposure profiles and modes of action substantially different from those of traditional chemicals. 2. Here we argue that it is important to understand the potential effects of environmental conditions (e.g. UV radiation, dissolved organic matter, chemical stressors) on the fate and ecotoxicological potential of nanoparticles by using simple and well-controlled experiments, while aiming to mimic realistic environmental conditions as closely as possible. 3. The observation that increasingly complex test systems may yield lower effect thresholds for nanoparticles than standardised tests suggests that current approaches require modification. Specifically, research is encouraged on interactions among trophic levels, community composition and ecosystem and evolutionary processes, so that effects observed in complex environmental settings can be explained mechanistically. 4. We highlight recent discoveries in ecotoxicology and ecology that suggest nanoparticle-induced consequences on evolutionary and ecosystem processes as well as their potential transfer across ecosystem boundaries. These insights may encourage further research on nanoparticle effects informed by ecological theory.

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“…A possible explanation could be that the present study utilized a quasi-natural exposure scenario through the use of sediment as the substrate, which contains high levels of natural organic matter (NOM). In previous studies, NOM has been shown to dramatically reduce toxicity through either ROS quenching or physicochemical characteristics (Lee et al, 2011;Al-Reasi et al, 2011). Our hypothesis is that this ROS quenching occurred, so while ROS may have been produced, it was suppressed Fig.…”

Section: Discussionmentioning

confidence: 79%