Biotolerance Study of the Hydroalcoholic Extract of &amp;lt;i&amp;gt;Terminalia mantaly&amp;lt;/i&amp;gt; H. Perrier on Rat Renal Activity

Emilie, Kamo Irie Lou Bohila; Otis, Tra Bi Irié; Serge, Kouassi Kouakou; Joseph, Djaman Allico; David, N’guessan Jean

doi:10.4236/jbm.2022.1012014

JBM

2022

DOI: 10.4236/jbm.2022.1012014

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Biotolerance Study of the Hydroalcoholic Extract of Terminalia mantaly H. Perrier on Rat Renal Activity

Kamo Irie Lou Bohila Emilie¹,

Tra Bi Irié Otis²,

Kouassi Kouakou Serge³

et al.

Abstract: Terminalia mantaly H. Perrier is one of the plants of the Combretaceae family that is widely used in traditional African medicine for its antibacterial, antifungal, and especially in the treatment of malaria. In this study, we evaluated the effect of the hydroalcoholic extract of Terminalia mantaly (HAETM) on

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2024

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Cardiac Tolerance of Hydroalcoholic Extract of Bark of Terminalia mantaly H. Perrier (HAEBTM) in Wistar Rats

Kamo,

Kouassi,

Atto

et al. 2024

AJMB

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Terminalia mantaly H. Perrier is a plant used in traditional medicine for the treatment of various pathologies. However, Terminalia mantaly H. Perrier could present potential health effects on patients. In order to determine the possible cardiotoxic effects of the hydro-alcoholic extract of the bark of Terminalia mantaly H. Perrier, (HAEBTM) forty (40) rats distributed randomly into 4 groups, including 10 animals per group (5 males and 5 females) were used. Animals in group 1 received distilled water and were used as a control group. On the other hand, groups 2, 3, 4 received oral administration a volume of the hydroalcoholic extract of Terminalia mantaly H. Perrier corresponding to 1 mL/100g of body weight at 150 mg/kg, 300 mg/kg, 600 mg/kg, respectively. The extract was administered daily at the same time for 28 days and serum was collected once a week to evaluate cardiac biochemical markers using spectrophotometric methods using a Cobas C311 ® HITACHI biochemistry system. After one month of study, all rats were euthanized by overdose of ether, and the hearts of the rats were removed for gross morphological and histopathological analysis. Results were analysed using variance analysis (ANOVA) to compare outcomes as a function of doses administered and treatment times. The biochemical parameters ALT, LDH, CPK, CPKMB showed no significant change (p < 0.05) in the group of treated rats compared to the controls. However, the activities of ALAT, LDH experienced variations over time and an increase in CPK and CPKMB were observed. Microscopic observations of heart tissue sections from rats treated with the hydroalcoholic extract of Terminalia mantaly showed no lesions, edema and necrosis. These results suggest that the hydroalcoholic extract of Terminalia mantaly did not interfere with the functioning or alter the integrity of the heart.

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Cardiac Tolerance of Hydroalcoholic Extract of Bark of Terminalia mantaly H. Perrier (HAEBTM) in Wistar Rats

Kamo,

Kouassi,

Atto

et al. 2024

AJMB

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Biotolerance Study of the Hydroalcoholic Extract of <i>Terminalia mantaly</i> H. Perrier on Rat Renal Activity

Cited by 1 publication

References 22 publications

Cardiac Tolerance of Hydroalcoholic Extract of Bark of <i>Terminalia </i><i>mantaly</i> H. Perrier (HAEBTM) in Wistar Rats

Cardiac Tolerance of Hydroalcoholic Extract of Bark of <i>Terminalia </i><i>mantaly</i> H. Perrier (HAEBTM) in Wistar Rats

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Biotolerance Study of the Hydroalcoholic Extract of &lt;i&gt;Terminalia mantaly&lt;/i&gt; H. Perrier on Rat Renal Activity

Cited by 1 publication

References 22 publications

Cardiac Tolerance of Hydroalcoholic Extract of Bark of &lt;i&gt;Terminalia &lt;/i&gt;&lt;i&gt;mantaly&lt;/i&gt; H. Perrier (HAEBTM) in Wistar Rats

Cardiac Tolerance of Hydroalcoholic Extract of Bark of &lt;i&gt;Terminalia &lt;/i&gt;&lt;i&gt;mantaly&lt;/i&gt; H. Perrier (HAEBTM) in Wistar Rats

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Biotolerance Study of the Hydroalcoholic Extract of <i>Terminalia mantaly</i> H. Perrier on Rat Renal Activity

Cardiac Tolerance of Hydroalcoholic Extract of Bark of <i>Terminalia </i><i>mantaly</i> H. Perrier (HAEBTM) in Wistar Rats

Cardiac Tolerance of Hydroalcoholic Extract of Bark of <i>Terminalia </i><i>mantaly</i> H. Perrier (HAEBTM) in Wistar Rats