Biotinylated magnetic molecularly imprinted polymer nanoparticles for cancer cell targeting and controlled drug delivery

Nerantzaki, Maria; Michel, Aude; Petit, Laurence; Garnier, Maylis; Ménager, Christine; Griffete, Nébéwia

doi:10.1039/d2cc00740a

Cited by 18 publications

(5 citation statements)

References 23 publications

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“…The mouse models used an external magnetic field to deliver the drugs. Recently, Nerantzaki et al proposed the DOX-loaded molecularly imprinted polymer adhering with Fe 3 O 4 nanoparticles [93]. They designed by using a biotinylated surface since biotin divides the cancer cells and thus, increases the drug uptake.…”

Section: Drug Deliverymentioning

confidence: 99%

Molecularly Imprinted Polymer-Coated Inorganic Nanoparticles: Fabrication and Biomedical Applications

et al. 2022

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Molecularly imprinted polymers (MIPs) continue to gain increasing attention as functional materials due to their unique characteristics such as higher stability, simple preparation, robustness, better binding capacity, and low cost. In particular, MIP-coated inorganic nanoparticles have emerged as a promising platform for various biomedical applications ranging from drug delivery to bioimaging. The integration of MIPs with inorganic nanomaterials such as silica (SiO2), iron oxide (Fe3O4), gold (Au), silver (Ag), and quantum dots (QDs) combines several attributes from both components to yield highly multifunctional materials. These materials with a multicomponent hierarchical structure composed of an inorganic core and an imprinted polymer shell exhibit enhanced properties and new functionalities. This review aims to provide a general overview of key recent advances in the fabrication of MIPs-coated inorganic nanoparticles and highlight their biomedical applications, including drug delivery, biosensor, bioimaging, and bioseparation.

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Section: Drug Deliverymentioning

confidence: 99%

Molecularly Imprinted Polymer-Coated Inorganic Nanoparticles: Fabrication and Biomedical Applications

et al. 2022

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“…MIPs are frequently conjugated to magnetically susceptible cores such as magnetite and/or maghemite, providing a platform that responds to an external magnetic field [ 60 ]. Additionally, such platforms could be used as contrast agents in MR imaging [ 61 ]. The conjugation of MIPs is mostly carried out on the magnetite surface, modified by tetraethyl orthosilicate and 3-(trimethoxysilyl)propyl methacrylate.…”

Section: Construction Strategies Of Mips For Diagnostics and Therapymentioning

confidence: 99%

Molecularly Imprinted Carriers for Diagnostics and Therapy—A Critical Appraisal

Balcer,

Sobiech,

Luliński

2023

Pharmaceutics

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Simultaneous diagnostics and targeted therapy provide a theranostic approach, an instrument of personalized medicine—one of the most-promising trends in current medicine. Except for the appropriate drug used during the treatment, a strong focus is put on the development of effective drug carriers. Among the various materials applied in the production of drug carriers, molecularly imprinted polymers (MIPs) are one of the candidates with great potential for use in theranostics. MIP properties such as chemical and thermal stability, together with capability to integrate with other materials are important in the case of diagnostics and therapy. Moreover, the MIP specificity, which is important for targeted drug delivery and bioimaging of particular cells, is a result of the preparation process, conducted in the presence of the template molecule, which often is the same as the target compound. This review focused on the application of MIPs in theranostics. As a an introduction, the current trends in theranostics are described prior to the characterization of the concept of molecular imprinting technology. Next, a detailed discussion of the construction strategies of MIPs for diagnostics and therapy according to targeting and theranostic approaches is provided. Finally, frontiers and future prospects are presented, stating the direction for further development of this class of materials.

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“…The nanoparticles belong to a typical core-shell structure, in which the hydrophilic polymer acts as a protective layer in the shell, and the hydrophobic fluorescent material acts as a fluorescent chromophore in the core. It not only retains the luminescent properties of fluorescent materials, but also improves the stability and biocompatibility of hydrophobic fluorescent materials in water systems [34][35][36]. Yu et al [37] designed and synthesized a semiconducting polymer PDFT based on diketopyrrolopyrrole (DPP).…”

Section: Physical Packagementioning

confidence: 99%

Design, Synthesis, and Biomedical Application of Multifunctional Fluorescent Polymer Nanomaterials

Xia

et al. 2023

Molecules

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Luminescent polymer nanomaterials not only have the characteristics of various types of luminescent functional materials and a wide range of applications, but also have the characteristics of good biocompatibility and easy functionalization of polymer nanomaterials. They are widely used in biomedical fields such as bioimaging, biosensing, and drug delivery. Designing and constructing new controllable synthesis methods for multifunctional fluorescent polymer nanomaterials with good water solubility and excellent biocompatibility is of great significance. Exploring efficient functionalization methods for luminescent materials is still one of the core issues in the design and development of new fluorescent materials. With this in mind, this review first introduces the structures, properties, and synthetic methods regarding fluorescent polymeric nanomaterials. Then, the functionalization strategies of fluorescent polymer nanomaterials are summarized. In addition, the research progress of multifunctional fluorescent polymer nanomaterials for bioimaging is also discussed. Finally, the synthesis, development, and application fields of fluorescent polymeric nanomaterials, as well as the challenges and opportunities of structure–property correlations, are comprehensively summarized and the corresponding perspectives are well illustrated.

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Biotinylated magnetic molecularly imprinted polymer nanoparticles for cancer cell targeting and controlled drug delivery

Abstract: Here, multivalent functions have been successfully integrated on a single core-shell type nanostructure, for remote-controlled and receptor-targeted intracellular delivery of doxorubicin (DOX) to breast cancer cells that overexpress biotin receptors.

Cited by 18 publications

References 23 publications

Molecularly Imprinted Polymer-Coated Inorganic Nanoparticles: Fabrication and Biomedical Applications

Molecularly Imprinted Polymer-Coated Inorganic Nanoparticles: Fabrication and Biomedical Applications

Molecularly Imprinted Carriers for Diagnostics and Therapy—A Critical Appraisal

Design, Synthesis, and Biomedical Application of Multifunctional Fluorescent Polymer Nanomaterials

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