Biotinylated-cationic zinc(II) phthalocyanine towards photodynamic therapy

Ghazal, Basma; Kaya, Esra Nur; Husain, Ali; Ganesan, Asaithampi; Durmuş, Mahmut; Makhseed, Saad

doi:10.1142/s1088424618501158

Cited by 16 publications

(8 citation statements)

References 55 publications

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“…singlet oxygen), coupled with high thermal and chemical stability, low-toxicity and high optical absorption (ɛ > 105 M À 1 cm À 1 ) (ɛ > 10 5 M À 1 cm À 1 ) in the visible and near-IR ranges (600-800 nm), make Pcs/AzaPcs excellent photosensitizers (PSs) for photodynamic therapy (PDT). [10] However, the insolubilities of these substances, associated with hydrophobicity and tendency to self-aggregate, leads to accumulation in physiological fluids and low binding affinities to targeted cancer cells. [9b,11] Different approaches have been sought to overcome these problems including introduction of polyvalent hydrophilic ligating sites (eg.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, and Physicochemical Studies Of Orientation‐Controlled Multi‐Arm PEG Zn(II)/Mg(II) (Aza)Phthalocyanines

et al. 2022

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Tuning the amphiphilicity of (aza)phthalocyanine hydrophobic cores by introducing multiple polyethylene glycol (PEG) moieties with controlled orientations of their (non)peripheral positions is an innovative approach to fabricating water-soluble macrocyclic materials. Although many water-soluble PEGylated macrocycles have been produced in this way, the ability to generate substances with PEG tails oriented outward from the macrocyclic plane in order to obtain non-aggregated, water soluble forms remains a challenge. In this study, we resolved this issue by developing a methods for the synthesis of four new dual directional PEG containing Zn(II)/Mg(II) amphiphiles (ZnPcÀ PEG, MgPcÀ PEG, ZnAzaPcÀ PEG and MgAzaPcÀ PEG). In addition, the non-aggregating behaviour, and photophysical and photochemical properties of these PEG-complexes were elucidated.

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Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, and Physicochemical Studies Of Orientation‐Controlled Multi‐Arm PEG Zn(II)/Mg(II) (Aza)Phthalocyanines

et al. 2022

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“…The PS molecule is excited because of absorption of energy irradiation. This energy is then transferred molecules to molecular oxygen (O 3 ) in the vicinity of the tumor [ 33 , 34 , 35 , 36 , 37 ]. The reactive oxygen species, such as: singlet oxygen ( 1 O 2 ) , hydroxyl radicals (HO · ), superoxide radical (O 2 ˙ − ), cause vascular damage, inflammation, and trigger neoplastic cells to cell death [ 38 , 39 , 40 ].…”

Section: Introductionmentioning

confidence: 99%

Coordination Complexes as a New Generation Photosensitizer for Photodynamic Anticancer Therapy

Pobłocki

Drzeżdżon

Kostrzewa

et al. 2021

IJMS

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Photodynamic therapy (PDT) has become an alternative to standard cancer treatment methods such as surgery, chemotherapy and radiotherapy. The uniqueness of this method relies on the possibility of using various photosensitizers (PS) that absorb and convert light emission in radical oxygen-derived species (ROS). They can be present alone or in the presence of other compounds such as metal organic frameworks (MOFs), non-tubules or polymers. The interaction between DNA and metal-based complexes plays a key role in the development of new anti-cancer drugs. The use of coordination compounds in PDT has a significant impact on the amount ROS generated, quantum emission efficiency (Φem) and phototoxic index (PI). In this review, we will attempt to systematically review the recent literature and analyze the coordination complexes used as PS in PDT. Finally, we compared the anticancer activities of individual coordination complexes and discuss future perspectives. So far, only a few articles link so many transition metal ion coordination complexes of varying degrees of oxidation, which is why this review is needed by the scientific community to further expand this field worldwide. Additionally, it serves as a convenient collection of important, up-to-date information.

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“…Beside the light conversation and light emitting devices [13][14][15] including the photodynamic therapy [16,17], phthalocyanine are widely studied in the field of organic field transistors [18], gas sensors [19], and biosensors [20,21].…”

Section: Introductionmentioning

confidence: 99%

Hybrid Functional Analysis of Electronic Properties of Transition-Metal Phthalocyanines

Klysko

Syrotyuk

2021

Ukr. J. Phys.

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This work presents the ab initio study of transition-metal phthalocyanines within a PBE0 hybrid functional. The list of metal impurities includes manganese, iron, cobalt, nickel, copper, and zinc. All calculations of isolated molecules have been performed with the use of the projector augment-wave method. For iron phthalocyanine, we have performed four calculations with different values of the mixing parameter a (the value of the exact exchange) – 0, 1/4, 1/3, and 1/2. For all other molecules, the calculations have been performed for a = 1/4 and 1/3. The electronic structure parameters including the HOMO-LUMO energy gap, Fermi level, magnetization, and imaginary part of the dielectric function are presented and compared with available theoretical and experimental data. Manganese, iron, and cobalt phthalocyanines show a strong dependence of electronic properties on the value of the exact exchange interaction. In other molecules with nickel, copper, and zinc, this dependence is not significant.

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Biotinylated-cationic zinc(II) phthalocyanine towards photodynamic therapy

Cited by 16 publications

References 55 publications

Synthesis, Characterization, and Physicochemical Studies Of Orientation‐Controlled Multi‐Arm PEG Zn(II)/Mg(II) (Aza)Phthalocyanines

Synthesis, Characterization, and Physicochemical Studies Of Orientation‐Controlled Multi‐Arm PEG Zn(II)/Mg(II) (Aza)Phthalocyanines

Coordination Complexes as a New Generation Photosensitizer for Photodynamic Anticancer Therapy

Hybrid Functional Analysis of Electronic Properties of Transition-Metal Phthalocyanines

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