Biotin-Stimulated Insulin Secretion in Biotin-Deficient Rats.

Furukawa, Yuji; Ohinata, Kosaku; Ikai, Michiyoshi; Maebashi, Masaru; Zhang, Hong; Kimura, Shuichi

doi:10.3164/jcbn.18.35

Cited by 9 publications

(5 citation statements)

References 17 publications

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“…In our previous study, the reduction of insulin secretion in biotin-deficient rats was significantly improved by the simultaneous administration of biotin and a glucose solution (11). Berdanier and Marshall (17) suggested that biotin may serve to enhance the synthesis or release of insulin in male adult rats.…”

Section: Discussionmentioning

confidence: 90%

“…In a long-term experiment using Osteogenic Disorder Shionogi (ODS) rats, which have a hereditary defect in their ability to synthesize ascorbic acid and which were fed a biotin-deficient diet containing dried egg white and sufficient ascorbic acid, we observed a decrease in plasma insulin at an early stage of biotin deficiency (10). The insulin secretion in response to an oral glucose load (1.8g glucose solution per kg body weight) in biotin-deficient Wistar male rats was approximately one-sixth less, in concentration terms, than that of pair-fed control rats (11). However, the insulin content of the pancreas in the same biotin-deficient rats was no lower than that of the control rats.…”

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confidence: 85%

“…However, the insulin content of the pancreas in the same biotin-deficient rats was no lower than that of the control rats. The reduction in insulin secretion of these biotin-deficient rats was significantly improved by the simultaneous administration of biotin (1mg per kg body weight) with the glucose solution (11). Despite the accumulation of such reports, the metabolic mechanism underlying these effects remains unclear.…”

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confidence: 97%

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A High Biotin Diet Improves the Impaired Glucose Tolerance of Long-Term Spontaneously Hyperglycemic Rats with Non-Insulin-Dependent Diabetes Mellitus.

Zhang

Osada

Maebashi

et al. 1996

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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The Otsuka Long-Evans Tokushima Fatty (OLETF) rat, serving as a spontaneously diabetic model with non-insulin-dependent diabetes mellitus (NIDDM), exhibits impaired glucose tolerance (IGT) at about 16 weeks of age. In this study, we investigated whether or not biotin, a water-soluble vitamin, improved the IGT of OLETF rats. To this end, we administered diets containing one of three levels of biotin, a high-biotin diet (BH), a normal-biotin diet (BN) and a basal-biotin diet (BB), to OLETF rats up to 24 weeks of age. An oral glucose tolerance test (OGTT) was performed four times between 13 and 22 weeks of age. The administration of a BH corrected the IGT of OLETF rats. Upon further investigation, we found that insulin secretion in the OLETF-BH rats was decreased to a significant extent, signaling that the hyperinsuline mia typical to the OLETF-BH rats had clearly improved. Body weights were significantly lower in the OLETF-BH group than in the other OLETF groups, even though the OLETF-BH rats showed a significantly higher average daily food intake. The body weight gain of the OLETF BH rats followed the same tendency as the control-LETO (Long Evans Tokushima Otsuka) rats (LETO-BB and LETO-BN). These results demonstrate that a high-level biotin diet can improve the glucose handicap in NIDDM rats. Key Words biotin, egg white, oral glucose tolerance test, NIDDM (non insulin-dependent diabetes mellitus), insulin secretion

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Section: Discussionmentioning

confidence: 90%

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confidence: 85%

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confidence: 97%

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A High Biotin Diet Improves the Impaired Glucose Tolerance of Long-Term Spontaneously Hyperglycemic Rats with Non-Insulin-Dependent Diabetes Mellitus.

Zhang

Osada

Maebashi

et al. 1996

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…Biotin, a water-soluble vitamin, is well known not only to act as a coenzyme with four substrate carboxylases (5), but also to perform some nonprosthetic group functions (6)(7)(8). From these reports, it could be concluded that biotin is deeply involved in various kind of cellular functions.…”

Section: Discussionmentioning

confidence: 98%

Percutaneous Absorption of Biotin in Healthy Subjects and in Atopic Dermatitis Patients.

Makino¹,

Osada

Sone

et al. 1999

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…H ZHANG et al biotin-deficient rats was significantly improved by the simultaneous administration of biotin (1mg per kg body weight) with the glucose solution (6). In addition, we recently found that the feeding of a high-biotin diet corrects impaired glucose tolerance (IGT) and the hyperinsulinemia of OLETF rats (a spontaneously diabet ic model with NIDDM) (7).…”

Section: Discussionmentioning

confidence: 99%

Biotin Administration Improves the Impaired Glucose Tolerance of Streptozotocin-Induced Diabetic Wistar Rats.

Zhang¹,

Osada²,

Sone³

et al. 1997

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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Biotin-Stimulated Insulin Secretion in Biotin-Deficient Rats.

Cited by 9 publications

References 17 publications

A High Biotin Diet Improves the Impaired Glucose Tolerance of Long-Term Spontaneously Hyperglycemic Rats with Non-Insulin-Dependent Diabetes Mellitus.

A High Biotin Diet Improves the Impaired Glucose Tolerance of Long-Term Spontaneously Hyperglycemic Rats with Non-Insulin-Dependent Diabetes Mellitus.

Percutaneous Absorption of Biotin in Healthy Subjects and in Atopic Dermatitis Patients.

Biotin Administration Improves the Impaired Glucose Tolerance of Streptozotocin-Induced Diabetic Wistar Rats.

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