Biotin-conjugated Ru(II) complexes with AIE characteristics as mitochondria-targeted photosensitizers for enhancing photodynamic therapy by disrupting cellular redox balance

Wei, Lai; He, Xiangdong; Zhao, Deming; Kandawa-Shultz, Martha; Shao, Guoqiang; Wang, Yihong

doi:10.1016/j.ejmech.2023.115985

European Journal of Medicinal Chemistry

2024

DOI: 10.1016/j.ejmech.2023.115985

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Biotin-conjugated Ru(II) complexes with AIE characteristics as mitochondria-targeted photosensitizers for enhancing photodynamic therapy by disrupting cellular redox balance

Lai Wei,

Xiangdong He,

Deming Zhao

et al.

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Cited by 4 publications

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Leveraging the Photofunctions of Transition Metal Complexes for the Design of Innovative Phototherapeutics

Lee,

2024

Small Methods

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Despite the advent of various medical interventions for cancer treatment, the disease continues to pose a formidable global health challenge, necessitating the development of new therapeutic approaches for more effective treatment outcomes. Photodynamic therapy (PDT), which utilizes light to activate a photosensitizer to produce cytotoxic reactive oxygen species (ROS) for eradicating cancer cells, has emerged as a promising approach for cancer treatment due to its high spatiotemporal precision and minimal invasiveness. However, the widespread clinical use of PDT faces several challenges, including the inefficient production of ROS in the hypoxic tumor microenvironment, the limited penetration depth of light in biological tissues, and the inadequate accumulation of photosensitizers at the tumor site. Over the past decade, there has been increasing interest in the utilization of photofunctional transition metal complexes as photosensitizers for PDT applications due to their intriguing photophysical and photochemical properties. This review provides an overview of the current design strategies used in the development of transition metal complexes as innovative phototherapeutics, aiming to address the limitations associated with PDT and achieve more effective treatment outcomes. The current challenges and future perspectives on the clinical translation of transition metal complexes are also discussed.

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Leveraging the Photofunctions of Transition Metal Complexes for the Design of Innovative Phototherapeutics

Lee,

2024

Small Methods

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Ru(II)-based aggregation-induced emission (AIE) agents with efficient 1O2 generation, photo-catalytic NADH oxidation and anticancer activity

Xu,

Da,

Wang

et al. 2024

Chinese Chemical Letters

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Design strategies for aggregation-induced emission photosensitizers with enhanced safety in photodynamic therapy

Gao,

Tian,

et al. 2024

Coordination Chemistry Reviews

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Biotin-conjugated Ru(II) complexes with AIE characteristics as mitochondria-targeted photosensitizers for enhancing photodynamic therapy by disrupting cellular redox balance

Cited by 4 publications

References 54 publications

Leveraging the Photofunctions of Transition Metal Complexes for the Design of Innovative Phototherapeutics

Leveraging the Photofunctions of Transition Metal Complexes for the Design of Innovative Phototherapeutics

Ru(II)-based aggregation-induced emission (AIE) agents with efficient 1O2 generation, photo-catalytic NADH oxidation and anticancer activity

Design strategies for aggregation-induced emission photosensitizers with enhanced safety in photodynamic therapy

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