Biotin biochemistry and human requirements

Zempleni, Janos; Mock, Donald M.

doi:10.1016/s0955-2863(98)00095-3

Cited by 137 publications

(89 citation statements)

References 103 publications

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“…Biotin in food is largely protein bound to both endogenous and exogenous biotinyl proteins. The proportion of free (water extractable) biotin versus proteinbound (released by acidic or enzymatic hydrolysis) biotin varies among foods; the majority of biotin in meats and cereals appears to be protein bound (Zempleni and Mock, 1999). Furthermore, published biotin values rely heavily on values for compound foods reported by the food manufacturer (Pennington and Church, 1985;Pennington, 1989).…”

Section: Resultsmentioning

confidence: 99%

“…Clinical findings of frank biotin deficiency include periorificial scaly dermatitis, conjunctivitis, loss of hair, loss of appetite, hallucinations, depression, and developmental delay. Recent evidence indicates that pregnant women develop marginal biotin deficiency during normal pregnancy Zempleni and Mock, 1999). The marginal biotin deficiency observed in pregnancy does not cause these pathognomonic clinical manifestations because the deficiency is mild; however, deleterious health consequences for the fetus are a concern because marginal biotin deficiency is teratogenic in several animal species (Zempleni and Mock, 2000).…”

Section: Introductionmentioning

confidence: 99%

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Determination of the biotin content of select foods using accurate and sensitive HPLC/avidin binding

Staggs

Sealey

McCabe

et al. 2004

Journal of Food Composition and Analysis

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Assessing dietary biotin content, biotin bioavailability, and resulting biotin status are crucial in determining whether biotin deficiency is teratogenic in humans. Accuracy in estimating dietary biotin is limited both by data gaps in food composition tables and by inaccuracies in published data. The present study applied sensitive and specific analytical techniques to determine values for biotin content in a select group of foods. Total biotin content of 87 foods was determined using acid hydrolysis and the HPLC/avidin-binding assay. These values are consistent with published values in that meat, fish, poultry, egg, dairy, and some vegetables are relatively rich sources of biotin. However, these biotin values disagreed substantially with published values for many foods. Assay values varied between 247 times greater than published values for a given food to as much as 36% less than the published biotin value. Among 51 foods assayed for which published values were available, only seven agreed within analytical variability (720%). We conclude that published values for biotin content of foods are likely to be inaccurate.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Determination of the biotin content of select foods using accurate and sensitive HPLC/avidin binding

Staggs

Sealey

McCabe

et al. 2004

Journal of Food Composition and Analysis

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show abstract

“…Foods relatively rich in biotin include egg yolk, liver and some vegetables. 41 Since the vitamin synthesised by the microflora in the colon can be absorbed, cases of deficiency are rare and there is a paucity of quantitative information about the biotin needs of humans. 42 Research by Ho and Cordain 43 indicated that symptoms of biotin deficiency are similar to that of essential fatty acid deficiencies (EFAD).…”

Section: Discussionmentioning

confidence: 99%

Dietary risk markers that contribute to the aetiology of hypertension in black South African children: the THUSA BANA study

Schutte¹,

Rooyen²,

Huisman³

et al. 2003

J Hum Hypertens

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Although clinical hypertension occurs less frequently in children than in adults, ample evidence supports the concept that the roots of essential hypertension extend back to childhood. Since little is available in the literature on causal dietary factors of hypertension in children, this study hypothesised that certain dietary factors can be identified as risk markers that might contribute to the aetiology of hypertension in black children. Children aged 10-15 years were randomly selected from 30 schools in the North West Province from 2000 to 2001. These children comprised 321 black males and 373 females from rural to urbanised communities, of which 40 male and 79 female subjects were identified with high-normal to hypertensive blood pressure. Blood pressure was measured with a Finapres apparatus and data were analysed with the Fast Modelflo software program to provide systolic, diastolic and mean blood pressure. A 24-h dietary recall questionnaire and weight and height measurements were taken.In a stepwise regression analysis, the following variables were significantly associated (Pp0.05) with blood pressure parameters of hypertensive males: biotin, folic acid, pantothenic acid, zinc and magnesium. Energy, biotin and vitamin A intakes were significantly associated with blood pressure parameters of hypertensive females. No significant dietary markers were indicated for any of the normotensive groups. Dietary intakes of all of these nutrients were well below the dietary reference intakes. In conclusion, the dietary results coupled with the cardiovascular parameters of this study identified folic acid and biotin as risk markers that could contribute to the aetiology of hypertension in black persons. The low intakes of these nutrients, among others, is a matter of serious concern, as is the increasing tendency towards urbanisation.

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“…The micronutrient biotin (also known as vitamin H or B7) is a small 244 Da watersoluble vitamin essential for life [1][2][3]. Biotin has a well-defined biological function in organisms from all three domains of life as a cofactor for biotin-dependent enzymes.…”

Section: Biotinmentioning

confidence: 99%

Mechanisms of Biotin Transport

Polyak¹

2015

Biochem Anal Biochem

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Biotin biochemistry and human requirements

Cited by 137 publications

References 103 publications

Determination of the biotin content of select foods using accurate and sensitive HPLC/avidin binding

Determination of the biotin content of select foods using accurate and sensitive HPLC/avidin binding

Dietary risk markers that contribute to the aetiology of hypertension in black South African children: the THUSA BANA study

Mechanisms of Biotin Transport

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