Biotic elicitation at different feeding time in cell suspension cultures of Eurycoma longifolia Jack, a valuable medicinal plant, for enhancement of cytotoxic activity of bioactive compounds against human colon cancer cell line

Kwan, Li See; Tan, Shu Ying; Hirata, Y.; Chan, Lai Keng; Nagaoka, Yasuo; Uesato, Shinichi; Boey, Peng‐Lim

doi:10.1007/s11627-021-10189-x

Cited by 2 publications

(2 citation statements)

References 48 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Earlier studies showed that natural products could exhibit several biological activities, such as inducing apoptosis-mediated proliferation inhibition through up-regulation of bax and caspase-3 and down-regulation of bcl2 genes [25][26][27], repressing insulin-like growth factor-1 and inducing Waf-1 gene expression [28,29], glutathione S-transferase activity [30] heat shock protein [31], anti-inflammatory [32,33] and inhibitor of GLI-mediated transcription, a pathway that causes the formation and progression of a variety of tumors [34]. The natural bioactive compound of the Lamiaceae family was also reported to exert anti-proliferative activity, which inhibits oncocyte growth, induction of differentiation, apoptosis, and induces G2/M arrest on cancer cells [35][36][37], and has potential antioxidant, anti-microbe, and anti-inflammatory properties [38,39]. The data obtained in this research were in agreement with the mentioned experiments.…”

Section: Discussionmentioning

confidence: 99%

Mentha longifolia L. Inhibits Colorectal Cancer Cell Proliferation and Induces Apoptosis via Caspase Regulation

Beheshtian,

Karimi,

Asili

et al. 2023

IJTM

View full text Add to dashboard Cite

Naturopathy or herbal medicine has been widely used as an alternative treatment for several illnesses, such as cancer, as they are generally acknowledged as a treatment with lesser side effects. This research evaluated the bioactive compounds profiling, antioxidant, and anticancer potential in Mentha longifolia L. (essential oil and extract), using different solvent polarities (hexane, methanol, and diethyl ether). Meanwhile, the caspase 3 gene expression and cell cycle status of methanolic extract were determined in colorectal cancer cells (Caco-2 and SW48). The overall findings showed that methanolic extraction exhibited the highest total phenolic and flavonoid with respective values of 59.25 mg GAE (Gallic acid) eq./g DW (dry weight) and 20.02 mg RE (Rutin) eq./g DW, respectively, compared to hexane and diethyl ether. Furthermore, piperitenone oxid and piperitonone were found to be the dominant volatile compounds in methanolic extracts and essential oils. Additionally, the methanolic extract possesses higher antioxidant and anticancer activities. The molecular analysis indicated that methanolic extract up-regulated the expression of caspase 3 and increased the SubG1 (method to detecting cell death) peaks in treated Caco-2 and SW48 cell lines. To conclude, M. longifolia L. could serve as an effective therapeutic agent and a remedy for several illnesses, such as cancer caused by oxidative stress.

show abstract

Section: Discussionmentioning

confidence: 99%

Mentha longifolia L. Inhibits Colorectal Cancer Cell Proliferation and Induces Apoptosis via Caspase Regulation

Beheshtian,

Karimi,

Asili

et al. 2023

IJTM

View full text Add to dashboard Cite

show abstract

“…Nhan and Loc [ 83 ] found that 200 mg/L YE and 20 µM each of MeJa and SA were ideal for enhancing the synthesis of eurycomanone. Similarly, Kwan et al [ 84 ] reported that YE, PEC, and VAL have positive effects on the synthesis of bioactive compounds in E. longifolia .…”

Section: Techniques For Improving the Synthesis Of Bioactive Compound...mentioning

confidence: 95%

Trends in the Tissue Culture Techniques and the Synthesis of Bioactive Compounds in Eurycoma longifolia Jack—Current Status and Future Perspectives

Sale,

Subramaniam,

Mad’ Atari

2023

Plants

View full text Add to dashboard Cite

Over the last two decades, there has been a concerted effort by researchers to mass propagate Eurycoma longifolia and improve the yield of its very important and sought-after anti-cancer and aphrodisiac bioactive compounds. To achieve this, various techniques have been used to mass propagate and improve the yield of these bioactive compounds in tissue cultures. These techniques include the optimization of media conditions and application of various types and combinations of plant growth regulators (PGRs). In addition, some elicitation techniques have been used to improve the synthesis of these bioactive compounds. However, in comparison with other herbal species with similar economic importance, many techniques have not been applied to E. longifolia. Adopting the most recent methodologies would ensure efficiency and sustainability in the in vitro production of bioactive compounds in E. longifolia. Therefore, in this review, we present an up-to-date record on the success stories in the tissue culture techniques and synthesis of bioactive compounds. In addition, we attempted to identify some of the missing links on the road to the effective and sustainable biotechnological utilization of this super important biological resource.

show abstract

Biotic elicitation at different feeding time in cell suspension cultures of Eurycoma longifolia Jack, a valuable medicinal plant, for enhancement of cytotoxic activity of bioactive compounds against human colon cancer cell line

Cited by 2 publications

References 48 publications

Mentha longifolia L. Inhibits Colorectal Cancer Cell Proliferation and Induces Apoptosis via Caspase Regulation

Mentha longifolia L. Inhibits Colorectal Cancer Cell Proliferation and Induces Apoptosis via Caspase Regulation

Trends in the Tissue Culture Techniques and the Synthesis of Bioactive Compounds in Eurycoma longifolia Jack—Current Status and Future Perspectives

Contact Info

Product

Resources

About