Biotechnology for micropropagation and camptothecin production in Ophiorrhiza sp.

Camptothecin-loaded supramolecular nanodelivery system based on amphiphilic calix[4]arene for targeted tumor therapy

“…Many clinical studies have shown that CPT and its derivatives can effectively inhibit a wide spectrum of human cancers, such as ovarian, bladder, colon, gastric, liver, leukemia, and breast cancers. [1][2][3][4][5][6][7][8] The structure-activity relationship indicated that the lactone ring in the structure of CPT significantly contributes to its anticancer activity. However, this could be broken into an inactive open loop through hydrolysis under physiological conditions.…”