Biotechnologies toward Mitigating, Curing, and Ultimately Preventing Edema through Compression Therapy

Hageman, Daniel J.; Wu, Shuying; Kilbreath, Sharon; Rockson, Stanley G.; Wang, Chun H.; Tate, Melissa L. Knothe

doi:10.1016/j.tibtech.2018.02.013

Cited by 11 publications

(8 citation statements)

References 63 publications

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“…The renovated interest of the scientific and industrial community towards compression treatment, specifically in edematous limbs, has led to a series of possible innovative proposals which are currently under scrutiny. 42 In order to get a higher degree of evidence, more randomized controlled trials on lymphedema treatment by means of different compression medical devices are to be performed.…”

Section: Resultsmentioning

confidence: 99%

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Compression therapy in lymphedema: Between past and recent scientific data

Mosti¹,

Cavezzi

2019

Phlebology

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Aim To extrapolate and discuss the scientific data on compression in lymphedema treatment, so to review old and innovative concepts about pressure, stiffness and other interplaying factors related to its efficacy and comfort. Material and methods Narrative review based on search in Medline/Google Scholar through key-words related to compression in lymphedema. Results Currently available literature lacks relevant details about data on protocol, devices, techniques, interface pressure, stiffness, as well as biases are represented by the different descriptions to present the outcomes. More recent evidence from adjustable wrap devices and elastic garments question the need for high pressure (especially for the upper limb) and stiffness in lymphedema treatment. Conclusions At present time a very strong compression pressure exerted by material with high stiffness seem to be questionable in lymphedema treatment. A low pressure provides the best outcomes in arm lymphedema, while a pressure in the range of 40–60 mm Hg seems to provide higher efficacy in lower limb lymphedema, provided it is maintained overtime. A high stiffness seems to be unnecessary to treat chronic edema. Future clinical trials, including proper description of treatment methodology and adequate investigating instrumental tools, are awaited to possibly corroborate the conclusive outcomes of our review.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Compression therapy in lymphedema: Between past and recent scientific data

Mosti¹,

Cavezzi

2019

Phlebology

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“…In contrast to rigid and nonconformable semiconductor‐based or silicon‐based sensors, these sensors employ flexible polymers coupled with various functional materials such as electrically conductive particles or piezoelectric nanomaterials or nanofibers. [ 89 ]…”

Section: Wearable Sensors For Remote Health Monitoringmentioning

confidence: 99%

Wearable Sensors for Remote Health Monitoring: Potential Applications for Early Diagnosis of Covid‐19

Mirjalali

Peng

Fang³

et al. 2021

Adv Materials Technologies

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Wearable sensors are emerging as a new technology to detect physiological and biochemical markers for remote health monitoring. By measuring vital signs such as respiratory rate, body temperature, and blood oxygen level, wearable sensors offer tremendous potential for the noninvasive and early diagnosis of numerous diseases such as Covid‐19. Over the past decade, significant progress has been made to develop wearable sensors with high sensitivity, accuracy, flexibility, and stretchability, bringing to reality a new paradigm of remote health monitoring. In this review paper, the latest advances in wearable sensor systems that can measure vital signs at an accuracy level matching those of point‐of‐care tests are presented. In particular, the focus of this review is placed on wearable sensors for measuring respiratory behavior, body temperature, and blood oxygen level, which are identified as the critical signals for diagnosing and monitoring Covid‐19. Various designs based on different materials and working mechanisms are summarized. This review is concluded by identifying the remaining challenges and future opportunities for this emerging field.

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“…New classes of mechanoactive materials will find uses i.a. in the medical and health sectors (Ng et al, 2017a;Hageman et al, 2018), in addition to safety and transport, military (Knothe Tate, 2011a), sports, and leisure wear sectors, cementing their disruptive status in the field of material science and advanced manufacturing (Knothe Tate et al, 2009;Sidler et al, 2018).…”

Section: Applications Future Directions and Conclusionmentioning

confidence: 99%

Advanced Design and Manufacture of Mechanoactive Materials Inspired by Skin, Bones, and Skin-on-Bones

Tate

2020

Front. Bioeng. Biotechnol.

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Life is mechanobiological. Natural living materials exhibit remarkable, emergent and smart properties under mechanical loading. Such materials are classified as mechanoactive , in contrast to electroactive polymers and materials that exhibit advanced properties when subjected to electrical stimulation. Cutting edge, multiscale imaging technologies have proven enabling for the elucidation of molecular to meso-scale structure and function of natural mechanoactive materials. Using Microscopy-Aided Design And ManufacturE, (MADAME) this perspective article describes mechanoactive properties of natural materials including skin-on-bones ( periosteum ) and bone itself. In so doing, it demonstrates the principle to emulate natural smart properties using recursive logic, the basis of many computer algorithms, and to design and manufacture mechanoactive materials and products using advanced manufacturing methods that also incorporate principles of recursive logic. In sum, the MADAME approach translates physically the computer science paradigm of recursion by implementing Jacquard textile methods, which themselves form a historical basis for computing machines, together with additive manufacturing methods including multidimensional printing, stereolithography, laser sintering, etc. These integrated methods provide a foundation and translational pathway for scaled-up manufacture of disruptive mechanoactive materials that will find use in fields as varied as medicine, safety, transport and sports, for internal (implants) and external (wearables) applications.

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Biotechnologies toward Mitigating, Curing, and Ultimately Preventing Edema through Compression Therapy

Cited by 11 publications

References 63 publications

Compression therapy in lymphedema: Between past and recent scientific data

Compression therapy in lymphedema: Between past and recent scientific data

Wearable Sensors for Remote Health Monitoring: Potential Applications for Early Diagnosis of Covid‐19

Advanced Design and Manufacture of Mechanoactive Materials Inspired by Skin, Bones, and Skin-on-Bones

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