Biotechnological Valorization of Marine Collagens

Fassini, Dario; Oliveira, Sara M.; Silva, Tiago H.; Reis, Rui L.

doi:10.1002/9781119143802.ch35

Cited by 3 publications

(6 citation statements)

References 164 publications

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“…Several non-porous collagen biomaterials, such as the Biopad [61], have been The analysis of the microscopic structure of the membranes was done to evaluate their particularities. Moreover, this was carried out to anticipate and assess their ability of cell supporting and to correlate their structure with characteristics such as fluids absorption [28,[61][62][63]. For this, the microscopic surface structure of all ASColl membranes was observed through SEM (Figure 6B).…”

Section: Membranes Developmentand and Characterizationmentioning

confidence: 99%

“…In particular, collagen membranes have been proposed, based in collagen alone or in combination with other components (e.g., hyaluronic acid, chitosan, elastin, alginates). This type of biomaterial can be achieved through different methods such as solvent casting [28], electrospinning [29] and spin-coating [30]. Moreover, they can be formulated with the additional capability to deliver therapeutic compounds such as growth factors or antimicrobials, functioning as a bioactive dressing.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, they can be formulated with the additional capability to deliver therapeutic compounds such as growth factors or antimicrobials, functioning as a bioactive dressing. They can also help to moisturize the skin surface and absorb the wound exudate excess and degraded components from the damage ECM, as well as growth-inhibiting molecules such as proteases, cytokines, and free radicals, while protecting the wound from trauma and microorganisms, allowing gaseous exchanges [28,[31][32][33]. Additionally, because of the gradual removal of excess water from the wound by the biomaterials, the type I collagen fibrils become stiffer, giving more resistance to the newly formed ECM [34].…”

Section: Introductionmentioning

confidence: 99%

“…In this way, these collagen biomaterials promise to help maintain the physiological morphology of the cells, support the growth of epidermal cells, prevent collagen degradation by collagenase activity and reduce reactive oxygen species (ROS), providing structural integrity to the damaged tissue [33][34][35][36][37]. Hence, scaffolds such as collagenous membranes are ideal to be applied in skincare [28,29].…”

Section: Introductionmentioning

confidence: 99%

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Potential of Atlantic Codfish (Gadus morhua) Skin Collagen for Skincare Biomaterials

et al. 2023

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Collagen is the major structural protein in extracellular matrix present in connective tissues, including skin, being considered a promising material for skin regeneration. Marine organisms have been attracting interest amongst the industry as an alternative collagen source. In the present work, Atlantic codfish skin collagen was analyzed, to evaluate its potential for skincare. The collagen was extracted from two different skin batches (food industry by-product) using acetic acid (ASColl), confirming the method reproducibility since no significant yield differences were observed. The extracts characterization confirmed a profile compatible with type I collagen, without significant differences between batches or with bovine skin collagen (a reference material in biomedicine). Thermal analyses suggested ASColl’s native structure loss at 25 °C, and an inferior thermal stability to bovine skin collagen. No cytotoxicity was found for ASColl up to 10 mg/mL in keratinocytes (HaCaT cells). ASColl was used to develop membranes, which revealed smooth surfaces without significative morphological or biodegradability differences between batches. Their water absorption capacity and water contact angle indicated a hydrophilic feature. The metabolic activity and proliferation of HaCaT were improved by the membranes. Hence, ASColl membranes exhibited attractive characteristics to be applied in the biomedical and cosmeceutical field envisaging skincare.

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Section: Membranes Developmentand and Characterizationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Potential of Atlantic Codfish (Gadus morhua) Skin Collagen for Skincare Biomaterials

et al. 2023

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“…Marine collagens have been reported as the safest source for obtaining collagen, showing lower antigenicity properties, free of zoonosis (e.g., bovine spongiform encephalopathy), greater absorption due to low molecular weight, minor constraints due to social/religious reasons and regulatory issues. Each type of collagen displays unique structural features varying according to the species and tissues (i.e., anatomical part) from where it is extracted (Silvipriya et al, 2015;Fassini et al, 2020;Seixas et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Macro and Microstructural Characteristics of North Atlantic Deep-Sea Sponges as Bioinspired Models for Tissue Engineering Scaffolding

et al. 2021

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Sponges occur ubiquitously in the marine realm and in some deep-sea areas they dominate the benthic communities forming complex biogenic habitats – sponge grounds, aggregations, gardens and reefs. However, deep-sea sponges and sponge-grounds are still poorly investigated with regards to biotechnological potential in support of a Blue growth strategy. Under the scope of this study, five dominant North Atlantic deep-sea sponges, were characterized to elucidate promising applications in human health, namely for bone tissue engineering approaches. Geodia barretti (Gb), Geodia atlantica (Ga), Stelletta normani (Sn), Phakellia ventilabrum (Pv), and Axinella infundibuliformis (Ai), were morphologically characterized to assess macro and microstructural features, as well as chemical composition of the skeletons, using optical and scanning electron microscopy, energy dispersive x-ray spectroscopy and microcomputed tomography analyses. Moreover, compress tests were conducted to determine the mechanical properties of the skeletons. Results showed that all studied sponges have porous skeletons with porosity higher than 68%, pore size superior than 149 μm and higher interconnectivity (>96%), thus providing interesting models for the development of scaffolds for tissue engineering. Besides that, EDS analyses revealed that the chemical composition of sponges, pointed that demosponge skeletons are mainly constituted by carbon, silicon, sulfur, and oxygen combined mutually with organic and inorganic elements embedded its internal architecture that can be important features for promoting bone matrix quality and bone mineralization. Finally, the morphological, mechanical, and chemical characteristics here investigated unraveled the potential of deep-sea sponges as a source of biomaterials and biomimetic models envisaging tissue engineering applications for bone regeneration.

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Marine sponge aquaculture towards drug development: An ongoing history of technical, ecological, chemical considerations and challenges

Maslin

Gaertner‐Mazouni

Debitus

et al. 2021

Aquaculture Reports

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Biotechnological Valorization of Marine Collagens

Cited by 3 publications

References 164 publications

Potential of Atlantic Codfish (Gadus morhua) Skin Collagen for Skincare Biomaterials

Potential of Atlantic Codfish (Gadus morhua) Skin Collagen for Skincare Biomaterials

Macro and Microstructural Characteristics of North Atlantic Deep-Sea Sponges as Bioinspired Models for Tissue Engineering Scaffolding

Marine sponge aquaculture towards drug development: An ongoing history of technical, ecological, chemical considerations and challenges

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