Biotechnological potentials of halophilic microorganisms and their impact on mankind

Dutta, Bhramar; Bandopadhyay, Rajib

doi:10.1186/s43088-022-00252-w

Cited by 23 publications

(9 citation statements)

References 103 publications

(88 reference statements)

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“…Table 3 shows different NPs synthesized using haloarchaea as well as their potential biological applications (Table 3). Additional factors such as salt, pH, temperature, and size affect the stability and efficiency of NPs (Dutta and Bandopadhyay, 2022). Abdollahnia et al (2020) studied the synthesis of silver and selenium nanoparticles by haloarchaea isolated from solar salterns.…”

Section: Synthesis and Application Of Bioactive Nanoparticles From Ha...mentioning

confidence: 99%

Bioactive molecules from haloarchaea: Scope and prospects for industrial and therapeutic applications

et al. 2023

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Marine environments and salty inland ecosystems encompass various environmental conditions, such as extremes of temperature, salinity, pH, pressure, altitude, dry conditions, and nutrient scarcity. The extremely halophilic archaea (also called haloarchaea) are a group of microorganisms requiring high salt concentrations (2–6 M NaCl) for optimal growth. Haloarchaea have different metabolic adaptations to withstand these extreme conditions. Among the adaptations, several vesicles, granules, primary and secondary metabolites are produced that are highly significant in biotechnology, such as carotenoids, halocins, enzymes, and granules of polyhydroxyalkanoates (PHAs). Among halophilic enzymes, reductases play a significant role in the textile industry and the degradation of hydrocarbon compounds. Enzymes like dehydrogenases, glycosyl hydrolases, lipases, esterases, and proteases can also be used in several industrial procedures. More recently, several studies stated that carotenoids, gas vacuoles, and liposomes produced by haloarchaea have specific applications in medicine and pharmacy. Additionally, the production of biodegradable and biocompatible polymers by haloarchaea to store carbon makes them potent candidates to be used as cell factories in the industrial production of bioplastics. Furthermore, some haloarchaeal species can synthesize nanoparticles during heavy metal detoxification, thus shedding light on a new approach to producing nanoparticles on a large scale. Recent studies also highlight that exopolysaccharides from haloarchaea can bind the SARS-CoV-2 spike protein. This review explores the potential of haloarchaea in the industry and biotechnology as cellular factories to upscale the production of diverse bioactive compounds.

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Section: Synthesis and Application Of Bioactive Nanoparticles From Ha...mentioning

confidence: 99%

Bioactive molecules from haloarchaea: Scope and prospects for industrial and therapeutic applications

et al. 2023

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“…Many algal species, including Spirulina sp. and D. salina, can produce β-carotene, glycerol, lipids, and essential omegafatty acids that can be used as food supplement sources [86,87]. Khazraee et al [88] utilized effluents of a dairy wastewater treatment plant as substrate in the anode, while Chlorella vulgaris was inoculated in the cathode.…”

Section: Marine Microalgaementioning

confidence: 99%

Integrated Marine Biogas: A Promising Approach towards Sustainability

et al. 2022

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Fossil fuel depletion, climate change, and increased global energy demands are the driving forces to find alternative sources of energy. Marine-based biorefinery has been recently discussed as a promising route to mitigate the environmental challenges, enhance the energy recovery, and provide a potential source for value-added products. Anaerobic digestion is a promising technology that can convert the organic compounds of marine ecosystems into biogas. To date, a comprehensive review incorporating integrated biogas potential and effective approaches to enhance seaweed digestibility for biogas production from marine resources has not been reported. Thus, the present review aims to explore and comprehensively present seaweed and other marine resources for potential biogas production. The basics and challenges of biogas production from seaweed are elucidated. The impact of biochemical composition on biogas and the microbial communities involved in anaerobic digestion of seaweed are discussed. Utilization of different techniques such as pretreatment, co-digestion, and sequential extraction of seaweed biomass to enhance the biogas yield and to mitigate the effect of inhibitors are presented. Specifically, this article evaluates the co-digestion of seaweed with other biomass feedstocks or liquid biowastes. Integration of marine microalgae cultivation on anaerobic digestate for value-added compound production, biogas upgrading, and bioenergy recovery provides a promising approach towards a zero-waste marine-based system.

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“…Haloarchaea have attracted global scientific attention due to their unique features related to the molecular machinery of nitrogen, biodegradable polymers, and carotenoid metabolism; their easy manipulation; their reduced space requirements for cultivation compared to other organisms like microalgae or yeast from which highly marketed compounds can be obtained; and their capacity to produce a wide array of biomolecules and metabolites with potential biotechnological applications compared to plants, bacteria, fungi, or eukaryotic algae [8,9]. Their remarkable resilience and functionality even in the face of challenging environmental conditions, including high salinity, intense ultraviolet (UV) radiation, elevated ion concentrations, and extreme temperatures and pH, make them good model organisms to be used as cell factories for different purposes compared to their bacterial counterparts [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

Bacterioruberin: Biosynthesis, Antioxidant Activity, and Therapeutic Applications in Cancer and Immune Pathologies

Giani,

Pire,

Martínez-Espinosa

2024

Marine Drugs

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Halophilic archaea, also termed haloarchaea, are a group of moderate and extreme halophilic microorganisms that constitute the major microbial populations in hypersaline environments. In these ecosystems, mainly aquatic, haloarchaea are constantly exposed to ionic and oxidative stress due to saturated salt concentrations and high incidences of UV radiation (mainly in summer). To survive under these harsh conditions, haloarchaea have developed molecular adaptations including hyperpigmentation. Regarding pigmentation, haloarchaeal species mainly synthesise the rare C50 carotenoid called bacterioruberin (BR) and its derivatives, monoanhydrobacterioruberin and bisanhydrobacterioruberin. Due to their colours and extraordinary antioxidant properties, BR and its derivatives have been the aim of research in several research groups all over the world during the last decade. This review aims to summarise the most relevant characteristics of BR and its derivatives as well as describe their reported antitumoral, immunomodulatory, and antioxidant biological activities. Based on their biological activities, these carotenoids can be considered promising natural biomolecules that could be used as tools to design new strategies and/or pharmaceutical formulas to fight against cancer, promote immunomodulation, or preserve skin health, among other potential uses.

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Biotechnological potentials of halophilic microorganisms and their impact on mankind

Cited by 23 publications

References 103 publications

Bioactive molecules from haloarchaea: Scope and prospects for industrial and therapeutic applications

Bioactive molecules from haloarchaea: Scope and prospects for industrial and therapeutic applications

Integrated Marine Biogas: A Promising Approach towards Sustainability

Bacterioruberin: Biosynthesis, Antioxidant Activity, and Therapeutic Applications in Cancer and Immune Pathologies

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