Biotechnological applications of supersonic cluster beam‐deposited nanostructured thin films: Bottom‐up engineering to optimize cell–protein–surface interactions

Abstract

Technological innovations in biomaterial sciences harness nanoparticle (NP) production, manipulation, and deposition with supreme precision, enabling the development of industrial processes. This review first discusses the basic components of this approach, introducing cluster sources, experimental apparatus, and growth mechanisms for NP formation. The second part of this review provides an overview of how the nanoscale bottom-up engineering can control protein adsorption, which in turn determines the fate of nanostructured coating for prokaryotic and mammalian (primary and stem) cell interactions. In addition, we briefly address the implications of the cluster beam deposition technique for nanostructuration of biocompatible microdevices and its potential as a facile coating method to promote protein-surface interactions for microarray applications in biotechnology.

Hydrophobic pinning with copper nanowhiskers leads to bactericidal properties

“…The reduction in cell viability is attributed to physical injury of Gram-negative E . coli [22–24]. Greater deformational stress is required to disrupt the thick bacterial cell walls from the outer-to-inner preface.…”

“…These hierarchical structures influence the hydrodynamic interaction of water drops and dissolved biomolecular entities, thereby affecting the capacity of surface bacterial colonization and biofilm formation [4, 27–31]. Additionally, the pinning behavior of water droplets on whisker topography versus flat control surfaces show hydrophobic droplets remain in the Wenzel regime [32].…”

Three‐dimensional patterning in biomedicine: Importance and applications in neuropharmacology

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“…However, the CNS has very minimal fibrillar matrix and collagen in ECM compositions, rendering it difficult to extrapolate the results from an in vivo perspective. Nanotemplate material fabrications, bottom–up nanoengineering, and physicochemical modulations of the neuronal culture environment provide new opportunities for neuropharmacology . For example, self‐assembled bioactive peptides derived from laminin when electrospun as nanofiber scaffolds provide long‐term survival of neuronal progenitors, which differentiate into neurons and astrocytes.…”

Electromagnetic Enhancement of Cancer Cells as Biomarkers for Nano Theranostics

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