Biotechnological Application of Polyhydroxyalkanoates and Their Composites as Anti-microbials Agents

Patel, Sanjay; Kharb, Simmi; Singh, Mamtesh; Singh, Gajendra Pratap; Lee, Jung-Kul; Bhatia, Shashi Kant; Kalia, Vipin Chandra

doi:10.1007/978-981-13-3759-8_8

Cited by 15 publications

(12 citation statements)

References 99 publications

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“…Afterwards, 100 μl of the bacteria containing McFarland 0.5 (1.5 Â 10 8 cfu/ml) were prepared and entered the tubes (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11). Then, the tubes were incubated at 37 C for 24 h, where the tube No.…”

Section: Determining Minimum Inhibitory Concentrationmentioning

confidence: 99%

“…The use of antimicrobial compounds has become widespread due to their importance. The application ranges of these compounds included in various fields such as biomedical equipment, food packaging, reduced food corruption, and improved water purification equipment [1,2]. However, the problem with these materials is that they show little resistance to the microbial cells that stick to surfaces permanently.…”

Section: Introductionmentioning

confidence: 99%

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A novel synthesis of new antibacterial nanostructures based on Zn-MOF compound: design, characterization and a high performance application

Akbarzadeh

Motaghi

Chauhan³

et al. 2020

Heliyon

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In this study, the novel zinc metal-organic frameworks (MOF) nanostructure has been employed, which was developed using an affordable, environmental friendly, efficient and fast method of ultrasound-assisted reverse micelle (UARM). These nanostructures were identified with various techniques such as FT-IR, XRD, BET, SEM, TG-DSC, TEM and EDS. It was found that the Zn-MOF samples have favorable physicochemical properties. The impact of experimental parameters of the UARM method is effective on the resulting properties, such as high surface area of the products that increases the interactions between the Zn-MOF nanostructure and bacteria.Their antibacterial activities were investigated using diffusion methods in agar and also with dilutions of Zn-MOF samples. Antibiotics (tetracycline and ampicillin) and their anti-biofilm effects were evaluated using microplate method. Obtained results revealed that the Zn-MOF nanostructures have high antibacterial properties which, could be due to the nature of the applied Zn-MOF as well as the optimization process. The Zn-MOF nanostructures could be a novel antibacterial material as biocatalyst processes.

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Section: Determining Minimum Inhibitory Concentrationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A novel synthesis of new antibacterial nanostructures based on Zn-MOF compound: design, characterization and a high performance application

Akbarzadeh

Motaghi

Chauhan³

et al. 2020

Heliyon

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“…PHAs are a family of linear thermoplastic bio-polyesters. They are synthesized by many microorganisms under unbalanced growth conditions, as an alternative nutrient (carbon) reserve [125,126]. Over the last three decades, many studies have investigated the physicochemical properties of this new class of biopolymers, revealing innumerable advantages in using PHAs as a biomaterial in medical applications thanks to their biocompatibility, mechanical stability, strength, and biodegradability under physiological conditions with non-toxic degradation products [127][128][129].…”

Section: Application Of Pha Electrospun Fibers In Wound Healingmentioning

confidence: 99%

“…Studies also explored pharmaceutical applications of some degradation products of PHA, finding that they can evoke an inhibitory effect on microbial growth [128][129][130][131]. To date over 100 units of PHA monomers have been identified and no studies have reported carcinogenesis induced by any PHA or their biodegradation products [125,128,129]. The properties of PHAs vary considerably depending on their monomer content and hence can be tailored by controlling their composition [126,132].…”

Section: Application Of Pha Electrospun Fibers In Wound Healingmentioning

confidence: 99%

“…The properties of PHAs vary considerably depending on their monomer content and hence can be tailored by controlling their composition [126,132]. Furthermore, PHAs can be surface modified, blended with other polymers, and composite with inorganic materials such as nanoparticles (NPs), nanocrystals (NCs), drugs, and biomolecules to enhance their biocompatibility, antimicrobial activity, mechanical and thermal properties, and degradation rates, depending on the required application [125,128,132].…”

Section: Application Of Pha Electrospun Fibers In Wound Healingmentioning

confidence: 99%

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Bio-Based Electrospun Fibers for Wound Healing

Azimi

Maleki

Zavagna

et al. 2020

JFB

149

106

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Being designated to protect other tissues, skin is the first and largest human body organ to be injured and for this reason, it is accredited with a high capacity for self-repairing. However, in the case of profound lesions or large surface loss, the natural wound healing process may be ineffective or insufficient, leading to detrimental and painful conditions that require repair adjuvants and tissue substitutes. In addition to the conventional wound care options, biodegradable polymers, both synthetic and biologic origin, are gaining increased importance for their high biocompatibility, biodegradation, and bioactive properties, such as antimicrobial, immunomodulatory, cell proliferative, and angiogenic. To create a microenvironment suitable for the healing process, a key property is the ability of a polymer to be spun into submicrometric fibers (e.g., via electrospinning), since they mimic the fibrous extracellular matrix and can support neo- tissue growth. A number of biodegradable polymers used in the biomedical sector comply with the definition of bio-based polymers (known also as biopolymers), which are recently being used in other industrial sectors for reducing the material and energy impact on the environment, as they are derived from renewable biological resources. In this review, after a description of the fundamental concepts of wound healing, with emphasis on advanced wound dressings, the recent developments of bio-based natural and synthetic electrospun structures for efficient wound healing applications are highlighted and discussed. This review aims to improve awareness on the use of bio-based polymers in medical devices.

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Biodegradable Plastics

Kumar¹,

Razdan²

2022

Plastic and Microplastic in the Environment

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Biotechnological Application of Polyhydroxyalkanoates and Their Composites as Anti-microbials Agents

Cited by 15 publications

References 99 publications

A novel synthesis of new antibacterial nanostructures based on Zn-MOF compound: design, characterization and a high performance application

A novel synthesis of new antibacterial nanostructures based on Zn-MOF compound: design, characterization and a high performance application

Bio-Based Electrospun Fibers for Wound Healing

Biodegradable Plastics

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