Biotechnological application of health promising bioactive molecules

Kumar, Pankaj; Shaunak, Ishani; Verma, Madan L.

doi:10.1016/b978-0-444-64323-0.00006-0

Cited by 13 publications

(3 citation statements)

References 67 publications

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“…The differentiating aroma of each plant makes them attractive for harvesting and depends on the season. The wide varieties of volatile aromatic constituents are usually studied with principal attention given to antimicrobial and antioxidant activity, among other things (22,(24)(25)(26)(27)(28). Besides this, the review article by Goto et al (29) highlights that the consumption of several wild plants also provides improvements in certain conditions, such as diabetes mellitus, hyperlipidemia, and cardiovascular diseases, because they contain many bioactive phytochemicals, especially terpenoids.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the Volatile Profiles and Identification of Differentiating Aromas of Wild Undervalued Plants

et al. 2022

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Wild edible plants have played an important role in traditional diets, including the Mediterranean diet. Many of these plants have acquired an undervalued status, since they are under-appreciated in terms of their nutritional, organoleptic qualities, or their seasonality. However, some of these species are still used in local gastronomy for their aromatic and taste characteristics. This study has investigated the quantitative and qualitative aromatic characteristics of seven undervalued wild plants that determine their organoleptic characteristics. Volatiles of the fresh leaves of each species have been determined by head-space solid-phase microextraction, a sensitive and solvent-free technique, coupled with gas chromatography and mass spectrometry. A total of 37 compounds with remarkable quantitative and qualitative differences were identified. In general, benzenoids and monoterpenoids were the most abundant groups, while branched unsaturated hydrocarbons, fatty alcohols, and sesquiterpenoids were the minor groups. Benzyl nitrile, benzyl isothiocyanate, p-cymene, and 2-hexenal were the main individual volatiles, while benzyl alcohol, eugenol, and α-copaene were the differentiating aromas. The results display that the undervalued species studied could be a suitable choice to include as new environmentally friendly crops, providing a double benefit to producers, because they are a possible way to achieve sustainable production systems, and they are an alternative for consumers, because these plants provide flavors that have high organoleptic qualities.

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Section: Introductionmentioning

confidence: 99%

Assessment of the Volatile Profiles and Identification of Differentiating Aromas of Wild Undervalued Plants

et al. 2022

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“…Alternatively, using natural sources is a well-established method for discovering new substances with possible therapeutic effects. This class of drugs comprises new bioactive compounds that are essential for the production of modern medicines ( Kumar et al., 2019 ). It also provides information on different classes of bioactive lead compounds for the discovery and development of novel drugs.…”

Section: Using a Combination Of Methodsmentioning

confidence: 99%

Assessing the potential of NS2B/NS3 protease inhibitors biomarker in curbing dengue virus infections: In silico vs. In vitro approach

Norshidah

Leow²,

Ezleen³

et al. 2023

Front. Cell. Infect. Microbiol.

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An increase in the occurrence of viral infectious diseases is a global concern for human health. According to a WHO report, dengue virus (DENV) is one of the most common viral diseases affecting approximately 400 million people annually, with worsening symptoms in nearly 1% of cases. Both academic and industrial researchers have conducted numerous studies on viral epidemiology, virus structure and function, source and route of infection, treatment targets, vaccines, and drugs. The development of CYD-TDV or Dengvaxia® vaccine has been a major milestone in dengue treatment. However, evidence has shown that vaccines have some drawbacks and limitations. Therefore, researchers are developing dengue antivirals to curb infections. DENV NS2B/NS3 protease is a DENV enzyme essential for replication and virus assembly, making it an interesting antiviral target. For faster hit and lead recognition of DENV targets, methods to screen large number of molecules at lower costs are essential. Similarly, an integrated and multidisciplinary approach involving in silico screening and confirmation of biological activity is required. In this review, we discuss recent strategies for searching for novel DENV NS2B/NS3 protease inhibitors from the in silico and in vitro perspectives, either by applying one of the approaches or by integrating both. Therefore, we hope that our review will encourage researchers to integrate the best strategies and encourage further developments in this area.

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“…Currently, with the rise of the herbal genomics and the combined analysis of multiple omics (transcriptomics, metabolomics), it has become a powerful tool for studying the secondary metabolic pathways and key genes of active ingredients in medicinal plants[ 23 , 24 ]. Meanwhile, due to the transformation of biotechnology methods such as genetic engineering and metabolic engineering, the research on active ingredients has developed rapidly, providing new avenues for modern Chinese medicine research [ 25 – 27 ]. Research on C .…”

Section: Introductionmentioning

confidence: 99%

Metabolomics and transcriptomics reveal the mechanism of alkaloid synthesis in Corydalis yanhusuo bulbs

Zhao,

Pan,

Tan

et al. 2024

PLoS ONE

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Corydalis yanhusuo W.T. Wang is a traditional herb. Benzylisoquinoline alkaloids (BIAs) are the main pharmacological active ingredients that play an important role in sedation, relieving pain, promoting blood circulation, and inhibiting cancer cells. However, there are few studies on the biosynthetic pathway of benzylisoquinoline alkaloids in Corydalis yanhusuo, especially on some specific components, such as tetrahydropalmatine. We carried out widely targeted metabolome and transcriptomic analyses to construct the biosynthetic pathway of benzylisoquinoline alkaloids and identified candidate genes. In this study, 702 metabolites were detected, including 216 alkaloids. Protoberberine-type and aporphine-type alkaloids are the main chemical components in C. yanhusuo bulbs. Key genes for benzylisoquinoline alkaloids biosynthesis, including 6-OMT, CNMT, NMCH, BBE, SOMT1, CFS, SPS, STOX, MSH, TNMT and P6H, were successfully identified. There was no significant difference in the content of benzylisoquinoline alkaloids and the expression level of genes between the two suborgans (mother-bulb and son-bulb). The expression levels of BIA genes in the expansion stage (MB-A and SB-A) were significantly higher than those in the maturity stage (MB-C and SB-C), and the content of benzylisoquinoline alkaloids was consistent with the pattern of gene regulation. Five complete single genes were likely to encode the functional enzyme of CoOMT, which participated in tetrahydropalmatine biosynthesis in C. yanhusuo bulbs. These studies provide a strong theoretical basis for the subsequent development of metabolic engineering of benzylisoquinoline alkaloids (especially tetrahydropalmatine) of C. yanhusuo.

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Biotechnological application of health promising bioactive molecules

Cited by 13 publications

References 67 publications

Assessment of the Volatile Profiles and Identification of Differentiating Aromas of Wild Undervalued Plants

Assessment of the Volatile Profiles and Identification of Differentiating Aromas of Wild Undervalued Plants

Assessing the potential of NS2B/NS3 protease inhibitors biomarker in curbing dengue virus infections: In silico vs. In vitro approach

Metabolomics and transcriptomics reveal the mechanism of alkaloid synthesis in Corydalis yanhusuo bulbs

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