Biosynthetic Skin Substitute vs. 1% Silver Sulfadiazine for Treatment of Inpatient Partial-thickness Thermal Burns

Management of Blisters in the Partial-Thickness Burn: An Integrative Research Review

“…The results favored biological and biosynthetic dressings for increased rates of wound healing, decreased scarring, reduction in the number of required dressing changes, and cost efficiency without significant differences in infection rates. [15][16][17][18][19][20][21] As technological scientific capabilities progressed in the laboratory setting, burn research also turned its interest to blister fluid and its inherent wound healing effects. Experiments in this area began in the late 1970s and have used both animal and human models, in vivo and in vitro.…”

“…15,16,21 Reasons postulated for these findings include maintenance of a moist wound healing environment, protection of fragile, newly formed epidermal cells along the wound surface, 16 and the lending of structural support for organization of fibroblasts and collagen during granulation. 65 The use of Biobrane ® has been cautious by some who fear risk of increased wound infection.…”

“…Randomized, prospective clinical trial of partialthickness burn treatment with Biobrane ® vs 1% silver sulfadiazine 43 patients with a total of 50 partial-thickness burn wounds Treatment with Biobrane ® reduced need for frequent dressing changes and was more successful than treatment with silver sulfadiazine (P ϭ 0.058) 15 Journal of Burn Care & Research mise in infection risk. [17][18][19][20] The superior physiologic healing environment provided by these temporary skin substitutes supports the débridment of blisters for their use.…”

“…The research suggests that the use of SSD in partial-thickness burns with blisters is not beneficial to healing in comparison with other available products and the ease of its use for the practitioner should not supersede the healing needs of the patient. [15][16][17][18][19][20][21] Several studies have compared topical enzymatic débriding agents to SSD in partial-thickness burns. Hansbrough 71 and Hansbrough et al 72 demonstrated faster healing rates with collagenase ointment while Soroff and Sasvary 73 had similar results with collagenase ointment and polymyxin B sulfate/bacitracin spray combination in comparison with SSD.…”

Commercial dressings for burns versus sweet ancient remedy

“…A number of dressings appear to have some benefits over other products in burn management, and this benefit relates to time to wound healing, the number of dressing changes and the level of pain experienced. Although not all the included studies showed difference between compared interventions, the results indicate that burns dressed with hydrogels [19,20], siliconcoated dressings [21,22], biosynthetic dressings [23][24][25][26] and antimicrobial dressings [27][28][29] healed more rapidly than those dressed with silver sulphadiazine or chlorhexidine-impregnated gauze dressings.…”