Biosynthetic intermediates to the macrocyclic trichothecenes

Cytotoxins, Mycotoxins and Drugs from a New Deuteromycete, Acremonium neo-caledoniae, from the Southwestern Lagoon of New Caledonia

“…As expected for a non-macrocyclic trichothecene (14), verrol 4-acetate proved much less cytotoxic on tumor cell lines than macrocyclic trichothecenes like verrucarin A and isororidin A ( Table 2). Verrol 4-acetate proved also devoid of antifungal and antibacterial properties ( Table 2), which is not surprising in view of the typically weak antibacterial activities of trichothecenes.…”

Marine natural products

“…284 The known synthetic intermediate, 2-carboxy-8-methoxy-naphthalene-1ol 285,286 was obtained as a natural product from Mycelium sterilium (red alga Kappaphycus alvarezii, coastal Indonesia). 287 Myrothecium verrucaria (sponge Hymeniacidon perleve, Bohai Sea, Lingshui Qiao, Dalian, China) afforded several known trichothecenes: 8-hydroxyverrucarin J 288 was isolated for the rst time as a natural product and isororidin E 289 and trichoverrin B 290 were isolated from a marine source for the rst time. 291 The marine bacterium, Bacillus pumilus (Microbial Type Culture Collection 5560), produced 4-phenylbutanoic acid.…”

Progress in Molecular and Subcellular Biology

“…4) and class D for the 7,8 epoxy derivatives (Fig. 6) needs to be established for the trichothecadiene, verrucarin K. More than likely, many of the more recently reported trichothecenes such as the trichoverrins, trichoverrols, and trichodermadienes serve as intermediates in the biosynthetic pathway to the macrocyclic trichothecenes (Jarvis et al 1981b). As in the previous reviews, the structures of the compounds will be reported in the 4 groups or classes which share certain features.…”